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Is ezetimibe a statin drug?

Can you take ezetimibe with other cholesterol lowering drugs?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Oct 18, 2020.

Official Answer

by Drugs.com

No, ezetimibe is not a statin drug, it is from the drug class cholesterol absorption inhibitor

Ezetimibe and statins are cholesterol lowering drugs that work different ways to reduce cholesterol.

  • Ezetimibe has its effect in the small intestine where it blocks cholesterol from being absorbed, so there is less cholesterol being delivered to the liver.
  • Statins lower the amount of cholesterol and lipoproteins that the body produces, by inhibiting an enzyme called HMG-CoA reductase. Statins also increase the LDL receptors on liver cells which increases the amount of LDL-cholesterol that can be absorbed out of the bloodstream and then the LDL-cholesterol is disposed of by being broken down.

Ezetimibe can be taken alone as a sole cholesterol lowering agent, or together with a statin or fenofibrate.

Bottom line:

  • Ezetimibe is not a statin medication, it is a cholesterol absorption inhibitor.
  • Ezetimibe,fenofibrate and statins are cholesterol lowering medications.
  • Ezetimibe can be taken together with statins or fenofibrate as their cholesterol lowering effects are complementary.
References

Ezetimibe Medication Information:  https://www.drugs.com/ezetimibe.html
Fenofibrate Medication Information: https://www.drugs.com/fenofibrate.html

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