Comparing Phenytoin vs Valproic Acid
| Phenytoin | Valproic acid |
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| Phenytoin | Valproic acid |
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Prescription only
Prescribed for Epilepsy, Seizures, Status Epilepticus, Anxiety, Cluster-Tic Syndrome, Neurosurgery, Seizure Prophylaxis During or Following Neurosurgery, Arrhythmia, Myotonia Congenita, Peripheral... View more |
Prescription only
Prescribed for Bipolar Disorder, Epilepsy, Cluster-Tic Syndrome, Headache, Seizure Prevention, Seizures, Hyperekplexia, Mania, Migraine, Migraine Prevention, Schizoaffective Disorder. Valproic acid... View more |
Related suggestions Seizures
Cluster-Tic Syndrome
Popular comparisons
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| More about Phenytoin | More about Valproic acid | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Phenytoin has an average rating of 7.5 out of 10 from a total of 117 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 15% reported a negative effect. |
Valproic acid has an average rating of 6.1 out of 10 from a total of 65 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 35% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Phenytoin side effects |
View all Valproic acid side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Phenytoin prices |
View all Valproic acid prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Di-Phen, Dilantin, Phenytek, Phenytoin Sodium, Phenytoin Sodium, Extended Release | Valproate Sodium | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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15 hours |
16 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
When Treating Epilepsy
Category X
Not for use in pregnancy
When Treating Migraine See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 863 drugs are known to interact with Phenytoin:
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A total of 427 drugs are known to interact with Valproic acid:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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January 06, 1953 |
February 28, 1978 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.