Phendimetrazine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Phendimetrazine	Wegovy (semaglutide)	Semaglutide	Enter another drug to compare

Phendimetrazine

Wegovy (semaglutide)

Semaglutide

Prescription only

Prescribed for Weight Loss (Obesity/Overweight). Phendimetrazine may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Weight Loss (Obesity/Overweight), Cardiovascular Risk Reduction, Nonalcoholic Steatohepatitis. Wegovy may also be used for purposes not listed in this medication guide.

Prescription only

Semaglutide (Ozempic, Rybelsus) lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the... View more

More about Phendimetrazine

More about Wegovy (semaglutide)

More about Semaglutide

Ratings & Reviews

Phendimetrazine has an average rating of 8.2 out of 10 from a total of 155 ratings on Drugs.com. 79% of reviewers reported a positive effect, while 10% reported a negative effect.

Wegovy has an average rating of 7.6 out of 10 from a total of 532 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 15% reported a negative effect.

Semaglutide has an average rating of 6.9 out of 10 from a total of 2795 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 20% reported a negative effect.

View all 155 reviews

View all 532 reviews

View all 2795 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Headaches (10.3%)
Insomnia (10.3%)
Anxiety (9.7%)
Dry mouth (9.0%)
Constipation (4.5%)
Depression (4.5%)
Loss of appetite (4.5%)

View all Phendimetrazine side effects

Nausea (32.3%)
Constipation (15.6%)
Vomiting (11.1%)
Diarrhea (9.8%)
Headaches (7.1%)
Heartburn (6.4%)
Tiredness (6.4%)

View all Wegovy side effects

Nausea (33.4%)
Constipation (15.2%)
Diarrhea (14.7%)
Vomiting (10.9%)
Headaches (6.7%)
Burping (6.7%)
Upset stomach (6.2%)

View all Semaglutide side effects

Drug Class

GLP-1 Agonists (Incretin Mimetics)

GLP-1 Agonists (Incretin Mimetics)

Generic Availability

Lower cost generic

No lower cost generic approved

N/A

Pricing and Coupons * Prices are without insurance

Quantity	14 tablet
Strength	35 mg
Per unit^*	$0.45
Cost^*	$6.34

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Dosage Forms

Oral capsule, extended release
Oral tablet

Subcutaneous solution

N/A

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

3.7 hours

168 hours

CSA Schedule ¹ View glossary of CSA terms

Moderate abuse potential

Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 174 drugs are known to interact with Phendimetrazine:

43 major drug interactions (190 brand and generic names)
129 moderate drug interactions (596 brand and generic names)
2 minor drug interactions (5 brand and generic names)

A total of 275 drugs are known to interact with Wegovy:

16 major drug interactions (37 brand and generic names)
258 moderate drug interactions (1458 brand and generic names)
1 minor drug interactions (10 brand and generic names)

A total of 275 drugs are known to interact with Semaglutide:

16 major drug interactions (37 brand and generic names)
258 moderate drug interactions (1458 brand and generic names)
1 minor drug interactions (10 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Using phendimetrazine with alcohol can increase the risk of cardiovascular side effects such as... View more

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

Disease Interactions

First Approval Date

October 20, 1975

N/A

December 05, 2017

WADA Class View classifications

S6 - Stimulants

N/A

More Information

Patient Resources

Phendimetrazine uses

Wegovy uses

Semaglutide uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Phendimetrazine Alternatives Compared

See also:

Wegovy

Zepbound

Mounjaro

Ozempic

Rybelsus

Victoza

Saxenda

Alli

Phentermine

Tirzepatide

Further information