Applies to the following strength(s): 35 mg ; 105 mg
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Obesity
-105 mg orally once a day, 30 to 60 minutes before morning meal
-35 mg orally 2 or 3 times a day, one hour before meals
-Maximum dose: 70 mg orally 3 times a day, one hour before meals
-For use as monotherapy only.
-Extended-release: The active drug in each extended release capsule approximates the action of three 35 mg immediate-release doses taken at 4 hour intervals.
-Immediate-release: Dosage should be individualized to obtain an adequate response with the lowest effective dose; 17.5 mg per dose may be adequate in some cases.
Use: Management of exogenous obesity as a short-term adjunct in a regimen of weight reduction based on caloric restriction in patients with
-an initial BMI of 30 kg/m2 or greater OR
-an initial BMI of 27 kg/m2 or greater in the presence of other risk factors (e.g., hypertension, diabetes, hyperlipidemia) who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone.
Renal Dose Adjustments
Data not available; Use with caution.
Liver Dose Adjustments
Data not available
When Tolerance to Anorectic Effect Develops (usually occurs within a few weeks):
-Discontinue treatment; maximum recommended dose should not be exceeded.
-Extended-release: Safety and efficacy have not been established in patients younger than 17 years.
-Immediate-release: Safety and efficacy have not been established in patients younger than 12 years.
Consult WARNINGS section for additional precautions.
US Controlled Substance: Schedule III
Data not available
-Overdosage: The management of acute overdosage is largely symptomatic and includes lavage and sedation with a barbiturate. The use of a nitrate or rapid-acting alpha receptor-blocking agent should be considered if hypertension is marked. Experience with hemodialysis and peritoneal dialysis is inadequate to permit recommendations for their use.
-Do not drink alcohol while taking this drug.
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- Drug class: anorexiants