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Phendimetrazine Dosage

Medically reviewed by Last updated on Aug 1, 2018.

Applies to the following strengths: 35 mg; 105 mg

Usual Adult Dose for Obesity

-105 mg orally once a day, 30 to 60 minutes before morning meal

-35 mg orally 2 or 3 times a day, one hour before meals
-Maximum dose: 70 mg orally 3 times a day, one hour before meals

-For use as monotherapy only.
-Extended-release: The active drug in each extended release capsule approximates the action of three 35 mg immediate-release doses taken at 4 hour intervals.
-Immediate-release: Dosage should be individualized to obtain an adequate response with the lowest effective dose; 17.5 mg per dose may be adequate in some cases.

Use: Management of exogenous obesity as a short-term adjunct in a regimen of weight reduction based on caloric restriction in patients with
-an initial BMI of 30 kg/m2 or greater OR
-an initial BMI of 27 kg/m2 or greater in the presence of other risk factors (e.g., hypertension, diabetes, hyperlipidemia) who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone.

Renal Dose Adjustments

Data not available; Use with caution.

Liver Dose Adjustments

Data not available

Dose Adjustments

When Tolerance to Anorectic Effect Develops (usually occurs within a few weeks):
-Discontinue treatment; maximum recommended dose should not be exceeded.


-Extended-release: Safety and efficacy have not been established in patients younger than 17 years.

-Immediate-release: Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule III


Data not available

Other Comments

-Overdosage: The management of acute overdosage is largely symptomatic and includes lavage and sedation with a barbiturate. The use of a nitrate or rapid-acting alpha receptor-blocking agent should be considered if hypertension is marked. Experience with hemodialysis and peritoneal dialysis is inadequate to permit recommendations for their use.

Patient Advice:
-Do not drink alcohol while taking this drug.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.