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Phendimetrazine and Depression: What Users Say

Brand names: Bontril PDM

Depression: mentioned by 7 users (4.5%)

Based on user experiences from 155 Phendimetrazine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

headaches 10.3%
insomnia 10.3%
anxiety 9.7%
dry mouth 9.0%
constipation 4.5%
depression 4.5%
loss of appetite 4.5%
heart palpitations 3.2%
tremors 2.6%
dizziness 1.9%

Reviews for Phendimetrazine

Commonly mentioned side effects
  • Anonymous
  • February 18, 2012

Phendimetrazine for Weight Loss (Obesity/Overweight) "Better concentration, increased motivation and mobility, eliminated food cravings, faster acting digestion and fluid loss, increased thirst, increased weight loss and inches, moderate increase in blood pressure, increase in overall physical stamina, and a significant decrease in depression."

9 / 10
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115 Report
  • Mas...
  • Taken for 1 to 6 months
  • September 30, 2016

For Weight Loss (Obesity/Overweight) "I have been on phendimetrazine as well as a natural thyroid pill since July. I have lost a total of 35 lbs, but I have changed my diet dramatically. I do not eat any bad carbs. I have also completely cut out sugar and only drink water. I do believe that I could've lost this weight with my diet change alone, because I have already done so in the past. Now, on my 3rd month, I have noticed that I am very irritable. I have been having a lot of anxiety and depression. I find myself having difficulty breathing, feeling as though what I am assuming is a panic attack. I feel as though I cannot swallow at times. I also find myself overcome with extreme sadness and get mad and feel violent. I also feel as if I am going a little insane. Be cautious."

8 / 10
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60 Report
  • Mas...
  • Taken for 1 to 6 months
  • September 30, 2016

For Weight Loss (Obesity/Overweight) "I have been on phendimetrazine as well as a natural thyroid pill since July. I have lost a total of 35 lbs, but I have changed my diet dramatically. I do not eat any bad carbs. I have also completely cut out sugar and only drink water. I do believe that I could've lost this weight with my diet change alone, because I have already done so in the past. Now, on my 3rd month, I have noticed that I am very irritable. I have been having a lot of anxiety and depression. I find myself having difficulty breathing, feeling as though what I am assuming is a panic attack. I feel as though I cannot swallow at times. I also find myself overcome with extreme sadness and get mad and feel violent. I also feel as if I am going a little insane. Be cautious."

8 / 10
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60 Report
  • Gol...
  • Taken for 10 years or more
  • July 19, 2021

For Weight Loss (Obesity/Overweight) "Warning: I have been doing phendimetrazine for over 3 years. It’s not easy to get off of it. Once I stop, I gain weight like crazy, lose all energy, and become depressed. Take only as prescribed. If you take more than you are supposed to, you will need many more a day in order to get it to work. You will have friends go to the doctor so that they give you their script too. Running out of pills before it’s time to renew your script will be a nightmare. These pills give you incredible amounts of energy, a euphoric feeling, you are never hungry, you will lose weight! But beware… It’s NOT EASY TO STOP THEM, and if you do… the energy level will dissipate and the weight will come back on."

10 / 10
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7 Report
  • Fat...
  • Taken for 1 to 6 months
  • September 7, 2018

For Weight Loss (Obesity/Overweight) "This medication does NOT work. I actually eat and crave more when I'm on it. Had difficulty sleeping. And when you're off of the medication, you feel depressed and extremely fatigued. I've been prescribed this medication by a bariatric doctor 2 months ago with NO RESULTS. I experienced better results from Phentermine."

3 / 10
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18 Report

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  • Ang...
  • November 5, 2015

For Weight Loss (Obesity/Overweight) "I'm a mom of 5. My youngest is 9 months. I've suffered weight gain the past 4 years. My weight has been 115/120 lbs even after my 3 kids. Once the 4th and 5th came, I have plateaued at 150. Can't drop these 30 lbs. My doctor put me on Adipex 37 mg last year, I went up to 172 lbs. I freaked out and became depressed. Was 172 down to 137 lbs. Then bam, baby #5 was in the oven. In February 2015, I saw my doctor about 1 month after the birth of #5 about starting Adipex again because I weighed in at 200 lbs. She agreed. Went from 200 lbs to 148 lbs. Now I'm back to 150. How depressing/frustrating. Saw the doctor yesterday and gained 3 lbs, and she recommended Bontril. Is this a good pill? What is the average weight loss from it? Please explain the best effect. Thank you so much."

5 / 10
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17 Report
  • Jay...
  • Taken for 1 to 6 months
  • February 20, 2015

Phendimetrazine for Weight Loss (Obesity/Overweight) "This medicine was working. Unfortunately, I also suffer from migraines and take Topamax. After about two months, I began depression. It was really bad."

6 / 10
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49 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.