Comparing Motrin vs Fioricet

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Motrin (ibuprofen)	Fioricet (acetaminophen / butalbital / caffeine)	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Motrin (ibuprofen)	Fioricet (acetaminophen / butalbital / caffeine)	Enter another drug to compare
Prescription and OTC Prescribed for Back Pain, Chronic Myofascial Pain, Aseptic Necrosis, Headache, Fever, Pain, Gout - Acute, Costochondritis, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia, Frozen Shoulder... View more	Prescription only Fioricet may be used for the short-term treatment of tension-type headaches; however, it is not a first-choice medicine because it is potentially habit-forming and causes sedation. Simpler and safer... View more	Related suggestions Headache Ibuprofen Acetaminophen / butalbital / caffeine OnabotulinumtoxinA Erenumab Ubrogepant Eptinezumab Popular comparisons Motrin vs Advil
More about (ibuprofen)	More about Fioricet (acetaminophen / butalbital / caffeine)
Ratings & Reviews
Motrin has an average rating of 8.5 out of 10 from a total of 16 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 7% reported a negative effect.	Fioricet has an average rating of 8.8 out of 10 from a total of 167 ratings on Drugs.com. 85% of reviewers reported a positive effect, while 7% reported a negative effect.
View all 16 reviews	View all 167 reviews
Drug Class
Nonsteroidal anti-inflammatory drugs	Analgesic combinations
Side Effects
Motrin side effects	Fioricet side effects
Generic Availability
Lower cost generic approved	N/A
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms Available
N/A	Oral capsule Oral tablet
Brand Names
Other ibuprofen brands include: A-G Profen, Actiprofen, Addaprin, Advil, Advil Children's, Advil Film-Coated, Advil Infant's Concentrated Drops, Advil Junior Strength, Advil Liqui-Gels, Advil Migraine, Caldolor, Cap-Profen, Children's ElixSure IB, Children's Motrin, Childrens Ibuprofen Berry, Genpril, Help I Have An Aching Body, IBU-200, Midol IB, Midol Maximum Strength Cramp Formula, Motrin Childrens, Motrin IB, Motrin Infant Drops, Motrin Junior Strength, Motrin Migraine Pain, Motrin Pediatric, NeoProfen, Nuprin, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Proprinal View more	Other acetaminophen / butalbital / caffeine brands include: Anolor 300, Capacet, Phrenilin Forte, Vanatol LQ, Vanatol S, Vtol LQ, Zebutal
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.
4 hours	35 hours
CSA Schedule ** View glossary of terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
C Category C Risk cannot be ruled out Prior To 30 Weeks Gestation D Category D Positive evidence of risk Starting At 30 Weeks Gestation See the full pregnancy warnings document.	C Category C Risk cannot be ruled out See the full pregnancy warnings document.
Drug Interactions
A total of 398 drugs are known to interact with Motrin: 97 major drug interactions (431 brand and generic names) 286 moderate drug interactions (1111 brand and generic names) 15 minor drug interactions (80 brand and generic names)	A total of 682 drugs are known to interact with Fioricet: 47 major drug interactions (197 brand and generic names) 584 moderate drug interactions (2547 brand and generic names) 51 minor drug interactions (270 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Ask your doctor before using ibuprofen together with alcohol. Do not drink alcohol while taking... View more	Ask your doctor before using acetaminophen together with alcohol. This can cause serious side... View more
Disease Interactions
Asthma Fluid retention GI toxicity Rash Renal toxicities Thrombosis PKU Anemia Hepatotoxicity Hyperkalemia Platelet aggregation inhibition	Alcoholism Liver disease Acute alcohol intoxication Drug dependence Liver disease Porphyria Rash Respiratory depression Cardiac disease Hypertension Psychiatric disorders PUD PKU Adrenal insufficiency Depression Hematologic toxicity Osteomalacia Paradoxical reactions Cardiotoxicity Liver disease Renal dysfunction Seizure disorders GERD
First Approval Date
N/A	N/A
WADA Class View World Anti-Doping Agency classifications.
N/A	N/A
More Information
Side effects Pregnancy warnings Breastfeeding warnings Dosage information Drug images Drug interactions Support group	Side effects Pregnancy warnings Dosage information Drug images Drug interactions Support group Pricing and coupons En Español
Patient resources
N/A	Fioricet uses
Professional Resources
Prescribing information	Prescribing information
Related Treatment Guide
Back Pain Chronic Myofascial Pain Aseptic Necrosis Headache Fever Pain Gout - Acute Costochondritis Diffuse Idiopathic Skeletal Hyperostosis Dysautonomia Frozen Shoulder Juvenile Rheumatoid Arthritis Muscle Pain Neck Pain Osteoarthritis Patent Ductus Arteriosus Period Pain Plantar Fasciitis Rheumatoid Arthritis Sciatica Spondylolisthesis Temporomandibular Joint Disorder show all	Headache

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

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Comparing Motrin vs Fioricet

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