Comparing Mirtazapine vs Trazodone

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Mirtazapine

Trazodone

Mirtazapine may be used in the treatment of depression; however, its use may be limited by its prominent sedative effects. Prescribed for Depression, Major Depressive Disorder. May also be prescribed... View more

Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Only generic forms are available which makes it a lot cheaper than some other... View more

Prescription only

Ratings & Reviews

View all 1676 reviews

View all 1273 reviews

Drug Class

Tetracyclic antidepressants

Phenylpiperazine antidepressants

Side Effects

Commonly reported side effects include: severe sedation, constipation, drowsiness, increased serum cholesterol, weight gain, fatigue, insomnia, increased appetite, xerostomia, and decreased appetite.

See the full mirtazapine side effects document.

Commonly reported side effects include: blurred vision, dizziness, drowsiness, headache, nausea, vomiting, and xerostomia.

See the full trazodone side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	100 each
Dosage	30 mg
Per Unit^*	$0.27 - $1.19
Cost^*	$27.05 - $118.95

View all mirtazapine prices

Quantity	7 tablet
Dosage	50 mg
Per Unit^*	$1.68
Cost^*	$11.75

View all trazodone prices

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Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Oral tablet
Oral tablet, disintegrating

Oral tablet

Brand Names

Remeron, Remeron SolTab Desyrel, Desyrel Dividose

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

40 hours

7.5 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 604 drugs are known to interact with mirtazapine:

127 major drug interactions (467 brand and generic names)
474 moderate drug interactions (1809 brand and generic names)
3 minor drug interactions (14 brand and generic names)

A total of 593 drugs are known to interact with trazodone:

125 major drug interactions (467 brand and generic names)
453 moderate drug interactions (1723 brand and generic names)
15 minor drug interactions (73 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of mirtazapine such as dizziness, drowsiness... View more

Alcohol can increase the nervous system side effects of traZODone such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

June 14, 1996

December 24, 1981

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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