Comparing Lisinopril vs Losartan

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Lisinopril	Losartan	Enter another drug to compare

Lisinopril

Losartan

Prescription only

Lisinopril can be used to treat high blood pressure and heart failure, and to increase survival following a heart attack. However, lisinopril may cause a persistent, dry, hacking cough which may... View more

Prescription only

Losartan works on a hormone called angiotensin II to lower blood pressure and may also improve kidney function in some people. People being initiated on losartan should be adequately rehydrated and... View more

More about Lisinopril

More about Losartan

Ratings & Reviews

Lisinopril has an average rating of 5.0 out of 10 from a total of 627 ratings on Drugs.com. 34% of reviewers reported a positive effect, while 44% reported a negative effect.

Losartan has an average rating of 4.5 out of 10 from a total of 578 ratings on Drugs.com. 26% of reviewers reported a positive effect, while 48% reported a negative effect.

View all 627 reviews

View all 578 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Cough (28.7%)
Dizziness (12.1%)
Headaches (10.2%)
Tiredness (7.5%)
Swelling (6.7%)
Fatigue (5.1%)
Pain (4.9%)

View all Lisinopril side effects

Dizziness (14.9%)
Anxiety (14.7%)
Tiredness (12.6%)
Headaches (12.1%)
Cough (11.9%)
Pain (10.9%)
Insomnia (8.3%)

View all Losartan side effects

Drug Class

Angiotensin Converting Enzyme Inhibitors

Angiotensin receptor blockers

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	100 each
Strength	20 mg
Per unit^*	$0.16 - $0.21
Cost^*	$15.72 - $20.50

View all Lisinopril prices

Quantity	50 each
Strength	50 mg
Per unit^*	$0.64
Cost^*	$32.05

View all Losartan prices

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Dosage Forms

Oral tablet

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

16.4 hours

4.4 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category D Positive evidence of risk

See the full pregnancy warnings document.

Drug Interactions

A total of 403 drugs are known to interact with Lisinopril:

44 major drug interactions (192 brand and generic names)
329 moderate drug interactions (1553 brand and generic names)
30 minor drug interactions (231 brand and generic names)

A total of 325 drugs are known to interact with Losartan:

32 major drug interactions (165 brand and generic names)
277 moderate drug interactions (1334 brand and generic names)
16 minor drug interactions (39 brand and generic names)

Alcohol/Food/Lifestyle Interactions

It is recommended that if you are taking lisinopril you should be advised to avoid moderately high... View more
Lisinopril and alcohol may have additive effects in lowering your blood pressure. You may... View more

If you are taking losartan you should avoid potassium-containing salt substitutes or... View more
Losartan and alcohol may have additive effects in lowering your blood pressure. You may experience... View more

Disease Interactions

First Approval Date

December 29, 1987

April 14, 1995

WADA Class View classifications

N/A

More Information

Patient Resources

Lisinopril uses

Losartan uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Lisinopril vs Losartan

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