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Generic Name: losartan (loe SAR tan)
Brand Names: Cozaar

What is Cozaar?

Cozaar (losartan) is an angiotensin II receptor antagonist. Losartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Cozaar is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.

Cozaar is used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure.

Important information

Do not use Cozaar if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Losartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

If you have diabetes, do not use Cozaar together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo).

In rare cases, Cozaar can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Before taking this medicine

You should not use Cozaar if you are allergic to losartan.

If you have diabetes, do not use Cozaar together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo).

You may also need to avoid taking Cozaar with aliskiren if you have kidney disease.

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Cozaar can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

To make sure Cozaar is safe for you, tell your doctor if you have:

  • kidney disease;

  • liver disease;

  • congestive heart failure;

  • an electrolyte imbalance (such as high levels of potassium in your blood);

  • if you are on a low-salt diet; or

  • if you are dehydrated.

It is not known whether losartan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Cozaar is not approved for use by anyone younger than 6 years old.

How should I take Cozaar?

Take Cozaar exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take Cozaar with or without food.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance.

Your blood pressure will need to be checked often. You may need other blood and urine tests at your doctor's office.

It may take 3 to 6 weeks of using Cozaar before your blood pressure is under control. For best results, keep using the medication as directed. Talk with your doctor if your condition does not improve after 3 weeks of treatment.

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture, heat, and light.

Cozaar dosing information

Usual Adult Dose of Cozaar for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day
Maintenance dose: 25 to 100 mg orally per day in 1 or 2 divided doses

Comments:
-If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day.
-Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks.

Uses:
-Treatment of hypertension.
-To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy.
-Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose of Cozaar for Hypertension:

Initial dose: 50 mg orally once a day
Maintenance dose: 25 to 100 mg orally per day in 1 or 2 divided doses

Comments:
-If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day.
-Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks.

Uses:
-Treatment of hypertension.
-To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy.
-Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose of Cozaar for Hypertension:

6 Years or Older:
Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total)

Comments:
-May be given as a tablet or suspension.
-Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Cozaar?

Drinking alcohol can further lower your blood pressure and may increase certain side effects of Cozaar.

Do not use potassium supplements or salt substitutes while you are taking Cozaar, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Cozaar side effects

Get emergency medical help if you have signs of an allergic reaction to Cozaar: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • pain or burning when you urinate;

  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;

  • chest pain;

  • high potassium - nausea, slow or unusual heart rate, weakness, loss of movement; or

  • kidney problems - little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath.

Common Cozaar side effects may include:

  • dizziness;

  • dry cough;

  • back pain; or

  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Cozaar?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • a diuretic or "water pill";

  • other blood pressure medications;

  • lithium;

  • celecoxib; or

  • aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may interact with losartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about Cozaar.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Cozaar only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 14.01. Revision Date: 2016-05-06, 3:26:45 PM.

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