Comparing Hydroxychloroquine vs Leflunomide

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Hydroxychloroquine

Leflunomide

Prescription only

Prescribed for Rheumatoid Arthritis, Lupus, Lichen Planopilaris, Lyme Disease - Arthritis, Dermatomyositis, Malaria, Malaria Prevention, Sjogren's Syndrome, Undifferentiated Connective Tissue... View more

Prescription only

Prescribed for Psoriatic Arthritis, Rheumatoid Arthritis. Leflunomide may also be used for purposes not listed in this medication guide.

More about Hydroxychloroquine

More about Leflunomide

Ratings & Reviews

Hydroxychloroquine has an average rating of 6.4 out of 10 from a total of 356 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 29% reported a negative effect.

Leflunomide has an average rating of 5.1 out of 10 from a total of 116 ratings on Drugs.com. 40% of reviewers reported a positive effect, while 46% reported a negative effect.

View all 356 reviews

View all 116 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Nausea (11.8%)
Rash (9.3%)
Pain (7.9%)
Fatigue (6.7%)
Headaches (6.7%)
Hair loss (5.6%)
Upset stomach (5.1%)

View all Hydroxychloroquine side effects

Hair loss (27.6%)
Diarrhea (13.8%)
Headaches (12.9%)
Nausea (11.2%)
High blood pressure (6.9%)
Shortness of breath (6.9%)
Weakness (6.9%)

View all Leflunomide side effects

Drug Class

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	50 each
Strength	200 mg
Per unit^*	$0.48
Cost^*	$24.08

View all Hydroxychloroquine prices

Quantity	50 each
Strength	20 mg
Per unit^*	$1.16
Cost^*	$58.24

View all Leflunomide prices

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Dosage Forms

Oral tablet

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

N/A

336 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category N Not classified

See the full pregnancy warnings document.

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Drug Interactions

A total of 593 drugs are known to interact with Hydroxychloroquine:

227 major drug interactions (725 brand and generic names)
348 moderate drug interactions (1295 brand and generic names)
18 minor drug interactions (54 brand and generic names)

A total of 697 drugs are known to interact with Leflunomide:

553 major drug interactions (2128 brand and generic names)
134 moderate drug interactions (417 brand and generic names)
10 minor drug interactions (41 brand and generic names)

Alcohol/Food/Lifestyle Interactions

You may want to limit your consumption of grapefruit or grapefruit juice during treatment with... View more

Leflunomide can be taken with or without food. It is important to take leflunomide regularly to... View more

Disease Interactions

First Approval Date

N/A

September 10, 1998

WADA Class View classifications

N/A

More Information

Patient Resources

Hydroxychloroquine uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Hydroxychloroquine vs Leflunomide

See also:

Saphnelo

Humira

Benlysta

Plaquenil

Remicade

Enbrel

Orencia

Rituxan

Infliximab

Adalimumab

Further information

Comparing Hydroxychloroquine vs Leflunomide

See also:

Further information

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