Comparing Hydrocodone vs Methadone
Hydrocodone | Methadone |
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Hydrocodone | Methadone |
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Prescription only
Hydrocodone is a potent pain-relieving medicine; however, its use is limited by its potential for addiction and dependence. It is one of the most misused opioids in the United States. Prescribed for... View more |
Prescription only
Methadone is a potent opioid analgesic that may be used to relieve severe pain unresponsive to other strong pain relievers; however, it is more commonly used to treat opioid addiction. There is a... View more |
Related suggestions |
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More about Hydrocodone | More about Methadone | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Hydrocodone has an average rating of 5.7 out of 10 from a total of 200 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 38% reported a negative effect. |
Methadone has an average rating of 8.7 out of 10 from a total of 606 ratings on Drugs.com. 84% of reviewers reported a positive effect, while 6% reported a negative effect. |
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Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Hydrocodone side effects |
View all Methadone side effects |
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Drug Class | |||||||||||||||||
Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Hydrocodone prices |
View all Methadone prices |
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Dosage Forms | |||||||||||||||||
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Brand Names | |||||||||||||||||
Hysingla ER | Methadone Diskets, Methadose, Methadose Sugar-Free | ||||||||||||||||
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
8 hours |
30 hours |
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CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
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Pregnancy Category | |||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 605 drugs are known to interact with Hydrocodone:
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A total of 837 drugs are known to interact with Methadone:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
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First Approval Date | |||||||||||||||||
N/A |
August 13, 1947 |
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WADA Class View classifications | |||||||||||||||||
N/A |
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More Information | |||||||||||||||||
Patient Resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.