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Hydrocodone User Reviews & Ratings

Brand names: Hysingla ER

Hydrocodone has an average rating of 5.5 out of 10 from a total of 194 reviews on Drugs.com. 44% of reviewers reported a positive experience, while 40% reported a negative experience.

Reviews for Hydrocodone

  • MoshP...
  • April 10, 2014

Zohydro ER (hydrocodone) for Pain "I would give this medicine 20 stars if I could. Finally a time release version of hydrocodone without any acetaminophen. I have been taking Norco 10/325 for a little over a year and it was starting to have little to no effect for my chronic back pain. I was always in constant fear about getting jumped up to oxycodone due to the Norcos not working anymore but then Zohydro comes along and changes the game! No side effects whatsoever for me and I'm getting a good 12 hrs of pain relief per dose! Another positive note is that I'm only taking 2 pills per day rather than taking 4-5 Norcos, and with the absence of acetaminophen I don't have to worry about damage to my liver anymore. THANK YOU ZO-HYDRO!"

10 / 10
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206 Report
  • spina...
  • Taken for 1 to 6 months
  • May 22, 2014

Zohydro ER (hydrocodone) for Pain "I am suffering with Arachnoiditis of the thoracic spine due to 2 arachnoid cyst surgeries. Zohydro is far superior at lowering pain levels. It also does not upset my intestines or cause liver damage. At pain reduction it is A The best pain reliever ever. It also does not have the ups and downs in regards to pain levels that Norco's have. It is about time that a hydrocodone only medication has been offered and I really hope that the special interest lawmakers don't get their way and this medication remains on the market."

10 / 10
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153 Report
  • Patrick...
  • Taken for 1 to 6 months
  • May 3, 2014

Zohydro ER (hydrocodone) for Pain "Suffering with chronic pain from debilitating spinal injuries, I was always prescribed Acetaminophen containing hydrocodone. I was always getting bad acid reflux and digestive problems I would explain this to my original pain management Dr. And he would switch me from Vicodin to Percocet and the constant stomach issues continued. I switched to a new Pain Dr. I told him I was feeling fatigue and constant acid reflux when taking my pain medicines. He suggested trying A time released pain medicine with no acetaminophen he felt I was taking too much Acetaminophen and perhaps too many pills period (4 pills a day) He suggested to try Zohydro, I Am forever grateful I switched. Great relief of back pain and stomach problems. 10 stars."

10 / 10
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151 Report

Frequently asked questions

  • Rockp...
  • July 26, 2015

Hysingla ER (hydrocodone) for Pain "I've had a really good experience with Hysingla ER. I have had dibilitating Sacrio, SI Joint, sciatic nerve pain for 6 years. Tried chiropractic care, acupuncture, massage therapy, physical therapy, injections, electro shock therapy, and norco 10/325 4x per day for the last 4 years. I did get some relief, but not enough to make my daily life enjoyable. It's been a struggle with pain daily. Especially with three small children. Two months ago, my pain dr recommended Hysingla ER to me (as a last resort before surgery) and I decided to give it a shot. I started at 20mg, 4 weeks later 30mg, 4 weeks later 40mg. I can't believe the difference of my life since starting Hysingla!! I can take long walks again! I can grocery shop again!"

10 / 10
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131 Report
  • Patti...
  • September 3, 2015

Zohydro ER (hydrocodone) for Pain "I have chronic arthritis and have for 25 years. Believe me I have tried everything. Finally pain clinic doc put me on Zohydro and I have my life back. I can't tell you how much it helps. Please don't let anything happen to where FDA takes this drug away. Why do the druggies have to ruin it for the people that are in pain always. Thank you Zohydro...thank you.."

10 / 10
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120 Report

Are you taking this medicine?

  • Anonymous
  • April 15, 2014

Zohydro ER (hydrocodone) for Pain "My doctor put me on this after my blood test came back showing signs of liver problems from the Vicodin I was taking. I'm actually much more satisfied with Zohydro. It only needs to be taken once daily instead of four times. I feel more consistent pain relief without the spikes and valleys of the other. Wish it would have been available sooner I could have avoided the possible liver damage I now have to deal with."

10 / 10
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132 Report
  • patsy...
  • Taken for 6 months to 1 year
  • October 8, 2014

Zohydro ER (hydrocodone) for Pain "I have horrible arthritis pain for many years...tried everything..I've been on Vicodin (10mg) 4 a day for about 6 years..Finally a pain clinic Dr. gave me Zohydro (40mg) 2 a day. I would say I am 80 percent pain free. Overall quality of life has changed. No more ups and downs. I have to remind myself to take the second pill. Thanks ZOHYDRO!"

10 / 10
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127 Report

More FAQ

  • Deenini
  • December 30, 2014

Zohydro ER (hydrocodone) for Pain "I have been taking Zohydro for two months now for herniated disc in back. I was taking Norco three times a day but would always wear off and with my liver condition, I was not keen on the acetaminophen that is in Norco. I can now go through my day pain free! I hope all the naysayers leave us chronic pain patients alone!"

10 / 10
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117 Report
  • Whoknew
  • March 27, 2016

Hysingla ER (hydrocodone) for Pain "I have had chronic lower back pain/degenerative disc disease for over 25 years, along with an L5 S1 diskectomy, my pain and my condition continue to get worse with time. In the past I have been on Oxycodone, Hydrocodone, Fentanyl, and just most recently, Oxycontin 30 mg time release, did not like them at all. Even more recently I was prescribed Hysingla 80mg time release. I have been taking it for two days now and I am amazed at how I feel when I wake up! No pain, and slight withdraw, at which point I take a 10 mg oxycodone for breakthrough pain. It's been forever since I have woken up happy. Don't notice any side effects yet, can say, that it certainly does not last he 24 hrs.... more like 12-14, and takes a few hours to start working..."

8 / 10
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105 Report
  • finally...
  • Taken for 1 to 6 months
  • June 18, 2014

Zohydro ER (hydrocodone) for Pain "After three years of taking oxycodone 10 ER and oxycodone 5 IR for three cervical anterior and posterior with instrument I ask my spine doctor to change me to Zohydro ER. The oxy was making me sick to my stomach and I was dizzy and tired. I have to report that after a few months on the Zohydro ER I was able to transition to not only getting off the oxy but I am almost pill free and pain free. I am so grateful for Zohydro ER. I was afraid I was getting addicted to the oxycodone and with the Zohydro ER I had no feeling of euphoria. I am so grateful. Thank you for giving me back my life."

10 / 10
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109 Report
  • Finny
  • August 24, 2018

Hysingla ER (hydrocodone) for Pain "I’ve had 9 surgeries since 2003. One total shoulder replacement that was done incorrectly and need to be redone. Failed shoulder cuff other arm so that causes constant pain. Total hip total knee. Three back surgeries! The last one in 2015 Spinal Fusion. I am in constant pain. I’ve tried everything. Injections,PT , burning of the nerves nothing helps! Pain doc has me on Hysingla 40 mg does nothing! Due to terrible upper gut ulcers from upper bowel obstruction ( that was because when I had an emergency splenectomy the surgeon tied a knot in my stomach!) I feel like all the docs treat me like a druggie it could be in my head but I do get the feeling even from the pharmacy I feel like a criminal and I’ve never done anything wrong with these stupid meds that do nothing! This Hysingla is sooo expensive! Thanks for letting me rant"

3 / 10
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67 Report
  • Non...
  • May 24, 2017

Hysingla ER (hydrocodone) for Pain "My Doctor switched me to this, no reason given. I'm 58 I have had Renal Cell Cancer, I have 1 kidney left . Heart Disease, Diabetic, Discs are gone, I am not a surgical candidate due to my health. I have never, taken illegal drugs nor have I failed a random urine test, pill count etc.... But, because of what other people do, I am grouped into that stereotype ... It's embarrassing, humiliating, not everyone is a addict or looking for drugs . But this is the worst drug, I have ever tried..."

1 / 10
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75 Report
  • Krissy
  • Taken for 1 to 6 months
  • June 13, 2019

Hysingla ER (hydrocodone) for Pain "Tried morphine and Percocet for severe intractable pain from injuries and surgery. Hysingla then prescribed as those did not help. Hysingla did nothing for my pain and also made my head feel swimmy and it’s very constipating like severely. Dr tried Norco and I’m finally pain free most of the day now first time in years. I really can’t say why hysingla didn’t work because norco Is the same ingredient but it didn’t work for me and norco really does work for me. Like amazingly. And I’ve never had to step up dosage nor ever had addiction or withdrawals to pain medication. (Only cymbalta for me was highly addictive and took me over a year to get off of it. Withdrawal was severe. Strange because they say opioids are not safe but for me they are and antidepressants were not. Very strange.)"

2 / 10
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56 Report
  • Still...
  • Taken for 1 to 6 months
  • May 1, 2016

Hysingla ER (hydrocodone) for Pain "Was forced to switch from 4 to 6 Norco every 24 hrs. to Hysingla ER 30. I've gotten massive headaches every day in the past 6 wks. since starting it, far less pain relief, itching and swollen abdomen. My Dr. insists I need to stick with it."

1 / 10
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81 Report
  • Stormy
  • Taken for 1 to 6 months
  • August 27, 2018

Hysingla ER (hydrocodone) for Pain "I have psoriatic arthritis, osteoarthritis, osteoporosis and fibromyalgia. All of which are very painful. I was on 7.5 narco's. Which actually worked. I have never abused medication. I take them only when needed. My pain WAS controlled. Then my doctor put me on hysingla ER. The medication is worthless. I have NO pain relief at all. When I told the doctor, the nurse red flagged me as an addict."

1 / 10
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61 Report
  • Cronin...
  • July 15, 2016

Hysingla ER (hydrocodone) for Pain "I've been a chronic pain patient for 10 plus years. My dr wanted me to try Hysingla 100 mg even though my other medication was working the best out of all the others I've tried and been on. I took the first does and I didn't seem to have any relief but I kept reminding myself what he and I discussed so I gave it another try. By this time my other medication is no longer in my system and now my pain is getting really bad so I called my dr's office. I was advised that the Hysingla would peak at 15 hours of taking it and sometimes takes a while to build up. After a few days my dr took me off of it, an asprin worked better then the Hysingla. I hope others don't have to suffer like I did."

1 / 10
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76 Report
  • Equus
  • Taken for less than 1 month
  • September 11, 2014

Zohydro ER (hydrocodone) for Pain "I have chronic back and neck pain from 2 car accidents, I was rear ended. Had to have a 3 level cervical fusion with titanium plate 5 years ago. I was on Exalgo 8 mg, with Dilaudid or Norco for breakthrough pain. Norco always worked better for breakthrough pain, but don't like being forced to take acetaminophen that's in Norco. Just switched to 10 mg Zohydro 2x/day. Side effects were headache, nausea and a knot in my stomach. Which lasted the first 1-2 hours. My Md gave me Zofran for nausea which worked. My pain control is great! I am also sleeping much better. I do take some Norco for breakthrough, but so much better! This is day 3, and side effects seem to be gone! Great medicine. Need to get coupon working for me. Thanks Zohydro!"

10 / 10
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88 Report
  • Wildcat
  • May 17, 2020

For Pain "Tris generic 5/325: I'm a 53 with DDD, RSD, scoliosis, failed back surgery syndrome, T8 fracture, 2 bulging thoracic discs, inflammatory arthritis and more. I've been in pain clinics off/on since my 20s. I tapered off 15 mg SA + 15 mg LA oxycodone q. 8 hrs before moving to AZ and haven't been on an opioid for a year. My pain doc prescribed 5/325 q. 6 hrs and it does absolutely NOTHING for my pain. My doctor won't increase the dose, but thanks to all the very helpful reviews here, I am going to get the PAR generic to see if it works better. It's very disheartening to be a legitimate pain patient, with conditions documented on MRI, CT, etc., and to be treated like a drug-seeking criminal, just because my pain is so severe I cannot function without opioids. Opioid hysteria has ruined pain management and doctors have become cowards. All the pain docs care about now is keeping their opioid prescribing numbers low and doing procedures with high reimbursement rates."

2 / 10
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42 Report
  • 5-O
  • September 23, 2015

Zohydro ER (hydrocodone) for Pain "I was taking Norco 10mg 4x a day but it wore off so fast, I asked the doctor for an increase of 20mg. He suggested 20mg Zohydro twice a day and 20 mg norco for breakthrough pain. The medicine is pricey and I had to give it up this month. I am shopping for price comparisons and I have the company coupon that will get 250 off. I didn't realize how effective it was until I gave it up. How stupid I was! This stuff covers me from getting out of the bed until it runs out, which is about 8 hours later, so I probably need to move up to the 30s. I have an appointment in a few days and I am going to tell my doc to keep the norco's and just adjust my zohydro and I will rob banks to pay for it.! I had my life back for awhile. I miss it."

10 / 10
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73 Report
  • TisLo...
  • November 5, 2015

Zohydro ER (hydrocodone) for Pain "I have only taken Zohydro ER today. After 5 years of constant pain due to a back injury and R.A today Is the first day I have been pain free. I can actually enjoy sitting up watch TV pain free. Just 24 hrs ago my pain was so bad it ruled my life. Thanks To Zohydro ER, I see a light at the end of a very very long tunnel. The only side effect I have experienced today is I have had spells of being a bit sick to my stomach. But I do think being pain free out weighs that."

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  • Anahid
  • Taken for less than 1 month
  • June 4, 2016

Hysingla ER (hydrocodone) for Pain "This medicine took forever to work at all and didn't touch my foot, back knee, or migraine pain. What it did do is make me horribly nauseous, gave me hot sweats and shakes, made my hair fall out by the handful, and costs almost $200 for 30 pills. The prescription card only covers a month but it was time and money wasted. What a horrible experience!"

1 / 10
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67 Report
  • Lumba...
  • Taken for 6 months to 1 year
  • November 20, 2015

Hysingla ER (hydrocodone) for Pain "MS-Contin 60mg daily since 1998 w/breakthru pain combo w/MSC-IR 30mg 3x day. Some dizzy + naseau @times w/MSContin. Began Hysingla ER 60mg daily 3 mo ago w/excellent results. No lumbar pain. 80% CSPINE pain reduction + NO side effects period. Does work around clock. Chronic discogenic pain in lumbar since 1989 post 3 level lumbar lami. PCDF C2-C5 + ACDF C5-C6 w/80% pain relief. Miracle Rx for me! NO addic. issues. Feel NO high w/sustained release meds. Just wish price will go down soon! Highly recommend for those w/mod- sev lumbar pain that tolerate opiates well. Also, like MSC, NO liver panels."

10 / 10
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70 Report
  • Dawn...
  • Taken for less than 1 month
  • March 27, 2016

Hysingla ER (hydrocodone) for Pain "I find that this medication is unable to relieve my severe back and neck pain. Not only that, I now have severe migraines with use of Hyslinga. I feel that more research was needed before releasing it. I cannot handle increased pain which it had caused asking with dizziness and fatigue."

4 / 10
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  • spanky...
  • June 15, 2015

Hysingla ER (hydrocodone) for Pain "After a year of different meds trying to control pain i was put on hysingla er 40 with roxy 15 for breakthru.No medications will t ake all my pain away .Hysingla er 40 with the roxy 15 gives me controlable pain without the high feeling.It has allowed me to be more active."

9 / 10
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69 Report
  • Sugar...
  • Taken for less than 1 month
  • March 15, 2015

Hysingla ER (hydrocodone) for Pain "Changed from several pills a day to the new Hysingla ER. Was hoping it was something I would like better for just once a day. I do NOT like this medication. You can not control the peaks due to it being time released and its unpredictable. Causes my eyes to feel heavy and hot.You can not drink at all with this drug, it will cause the medication to be released too quickly, possible overdose. I don't like having no control and I was having break though pain as well."

3 / 10
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70 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.