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Hydrocodone use while Breastfeeding

Drugs containing Hydrocodone: Norco, Vicodin, Lortab, Hydrocodone CP, Tussionex Pennkinetic, Hysingla ER, Vicoprofen, Hydromet, Hycodan, Hydrocodone HD, Show all 350 »Lorcet, Zohydro ER, Hycet, Vicodin ES, Anexsia, Condasin, Narcof, Ibudone, Vortex, Vicodin HP, Triant-HC, Hydrocet, Hycomine, TussiCaps, Coughtuss, Lorcet 10/650, Reprexain, Lorcet Plus, Zutripro, Flowtuss, Phenylephrine HD, Zamicet, Xodol, Stagesic, Hydrocod-GF, Lorcet HD, Maxidone, Xylon 10, Hycofenix, Damason-P, Tussigon, Novasus, Dolacet, Hydrocodone GF, Histussin HC Syrup, Histinex PV, Hydron PCS, Relasin-HC, Tussinate, Hydromide, Codituss DH, Hydropane, Hydrotropine, Hydrocodone PA Pediatric, Prolex DH, Rezira, Marcof Expectorant, Nalex Expectorant, MonteFlu HC, Vicodin Tuss, CodiCLEAR DH, Hycotuss Expectorant, Pneumotussin, Tussafed-HC, Ambi 5/15/100, Obredon, Rindal HPD, M-END, Zydone, Liquicet, Zolvit, Duratuss HD, HydroFed, Lortab ASA, Crantex HC, Entuss-D JR, Panasal 5/500, Nazarin HC, Nariz HC, Guiaplex HC, Donatussin DC, Exetuss-HC, Simuc-HD, Qual-Tussin DC, Decotuss-HD, Gentex HC, Tussadur-HD, Spantuss HD, Medtuss HD, KG-Tuss HD, Vanacon, Su-Tuss HD Elixir, Drituss HD, Hytussin Expectorant, Tussafin Liquid, Hydrotussin HD, Entuss-D, Detussin Expectorant, Tussend Expectorant, Uni-Lev 5.0, Tussgen Expectorant, SRC Expectorant, Poly-Tussin XP, Deconamine CX, Vanex Expectorant, De-Chlor G, Pancof XP, Execof, Tusso-DF, Touro HC, Xpect-HC, Extendryl HC, Atuss HX, Entuss, Pneumotussin 2.5, Vitussin Expectorant, Cotuss V, Hydrotuss, Gua HC, Medcodin, Hycoclear, Hydro-Tussin HG, Canges-XP, Atuss G, Mintuss G, Tusnel-HC, Levall 5.0, Hydro GP, Dynatuss HC, Hydro-Tuss XP, VasoTuss HC, BPM PE HC, Monte-G HC, Z-Cof HCX, Tussicle, A-Cof DH, S-T Forte, Relasin-HCX, Tussafed-HCG, Pseudatex HC, De-Chlor NX, Hydron EX, Procof, Hy-KXP, KGS-HC, Mintuss NX, Hydron KGS, Atuss EX, Entuss Expectorant, Hycomine Pediatric, Codamine Pediatric, Codamine, Hycophen, Hycophen Pediatric, Protuss, Hypamine, Protuss-D, Procof D, SymTan, Pancof HC, ColdCough HCM, Liquituss HD, Detussin, Zymine HC, Histussin D, H-C Tussive D, Entuss-D Liquid, Tussgen, Tussafin, P-V-Tussin, Hytussin, Histinex D, Iotussin D Liquid, Verdrocet, Co-Gesic, T-Gesic, Hy-Phen, Panacet, Margesic H, Hydrogesic, Ru-Tuss with Hydrocodone, Rolatuss with Hydrocodone, Vanacet, Dolagesic, Alor 5/500, Hycoclar Tuss, Entex HC, Azdone, Anolor DH5, Zyfrel, Theracodophen Low 90, Vetuss HC Syrup, Duradyne DHC, De-Chlor MR, Hydrophene DH, Codal-DH Syrup, Mintuss MR, Trimal DH, Poly Hist HC, Tussplex, Hyco-DH, Dicomal-DH, Nalex-DH, Tusdec-HC, Lortuss HC, Duocet, Hycomal DH, PhendaCof Plus, Dynex HD, G-Tuss, Tuss-DS, Cytuss HC, Histussin HC Liquid, Efasin-HD Plus, Quindal HD Plus, Hi-Tuss HC, Quindal HD, H-C Tussive, Uni Tuss HC, Maxi-Tuss SA, Ventuss Syrup, Tuss-HC, Maxi-Tuss HC, Histinex HC, Highland HC, KG-Dal HD Plus, Chlorphen HD, Duradal HD, Echotuss-HC, Rindal HD Plus, Uni-Tricof HC, Phendal-HD, Relacon-HC NR, Neo HC, Tusana-D, Hydro-PC II Plus, Atuss MS, B-Tuss, Tussive HC, Liquitussin HC Syrup, Hydro-PC II, Hydron CP, De-Chlor HC, De-Chlor HD, Comtussin HC, Enplus-HD, Chemdal HD, Endagen-HD, Excof, Iodal HD, Rindal-HD, Efasin-HD, Ed-TLC, Donatussin MAX, Excof-SF, S-T Forte 2, Histex HC, Mintex HC, HyTan, Vituz, Max HC, Tri-Vent HC, Guiaphen HD, Mintuss MS, Endotuss-HD, KG-Dal HD, Tuss-PD, Ditussin-HC, Chemtussin HC, Endal-HD Plus, Exo-Tuss, Hyphen-HD, Cyndal HD, Chemdal HD Plus, Vanex-HD, Nasatuss, Iotussin HC, Ed-Tuss HC, Chlorgest HD, Poly-Tussin HD, Liquicough HC, Drocon-CS, Anaplex HD, Bromplex HD, Canges-HC, VazoTuss HC, Canges-HC NR, FluTuss HC, Bromph HD, Visvex, Hydro-DP, Bromcomp HC, Hycomine Compound, Endal HD, Gestuss-HC, D-Tann HC, Dytan-HC, Maxi-Tuss HCG, EndaCof-Tab, Co-Tuss V Expectorant, Fentuss Expectorant, Codotuss, Vicoclear, Endacof XP, Vicotuss, Hycosin Expectorant, Co-Tussin, Vi-Q-Tuss, Tusso-HC, Ztuss ZT, Execlear, Pneumotussin HC, Kwelcof, Propatuss Expectorant, Hydex PD, EndaCof-Plus, Pediatex HC, JayCof-HC, Detuss, Tussend, Welltuss HC, Hyphed, Hexatussin, Notuss, Notuss-Forte, Maxi-Tuss HCX, Z-Cof HC, DroTuss-CP, Relacon-HC, J-Tan D HC, Brovex HC, SymTan A, Tussin-V, Q-V Tussin, Cytuss-HC NR, Endacof HC, Atuss HS, H-C Tussive-NR, Zotex HC, Notuss PD, Codimal DH, Atuss HD, Cordron-HC NR, KG-Tussin, A-G Tussin, P-V-Tussin Syrup, Hydrotuss HC, Cordron-HC, Hydrocof-HC, Z-Tuss 2

Hydrocodone Levels and Effects while Breastfeeding

Summary of Use during Lactation

Maternal use of oral narcotics during breastfeeding can cause infant drowsiness, central nervous system depression and even death. Newborn infants seem to be particularly sensitive to the effects of even small dosages of narcotic analgesics. Once the mother's milk comes in, it is best to provide pain control with a nonnarcotic analgesic and limit maternal intake of oral hydrocodone to a few days at a maximum dosage of 30 mg daily with close infant monitoring. If the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing difficulties, or limpness, a physician should be contacted immediately.

Drug Levels

Hydrocodone is metabolized to 6 active metabolites, including hydromorphone.

Maternal Levels. Two hospitalized mothers were taking hydrocodone and acetaminophen combination for pain and pumped their milk for their nonhospitalized infants. They donated samples of their pumped milk for analysis of hydrocodone. One mother had 17 milk hydrocodone levels measured over 4 days while taking first 10 mg and then 5 mg of hydrocodone bitartrate as needed, beginning on day 7 postpartum. Her milk hydrocodone levels ranged from 8.6 to 127.3 mcg/L. The second mother had 5 milk hydrocodone levels measured over 1.5 days while taking 5 mg doses of hydrocodone bitartrate. Her milk hydrocodone levels ranged from 5.2 to 47.2 mcg/L, beginning at day 16 postpartum. Their infants received an estimated 3.1 and 3.7% of the maternal weight-adjusted dosages, but the absolute hydrocodone dosages were 8.58 mcg/kg and 3.07 mcg/kg daily because of the differences in the dosages ingested by their mothers.[1]

A study of 30 postpartum women taking a hydrocodone-containing product for postpartum pain measured hydrocodone and hydromorphone in breastmilk. Milk samples were collected after lactogenesis II was judged to have occurred, usually starting on the third postpartum day. Mean and median maternal dosages of hydrocodone base were 175 and 145 mcg/kg daily, respectively (range 44.3 to 423.2 mcg/kg daily). The mean and median milk hydrocodone concentrations were 25.9 and 14.2 mcg/L, respectively. Only 12 of the 30 women had hydromorphone detectable (>1 mcg/L) in their milk with a median milk hydromorphone concentration of 1.9 mcg/L. Mean and median infant daily dosages of hydrocodone were 3.9 and 2.1 mcg/kg, respectively, which were equal to 2.4 and 1.6% of the weight-adjusted maternal dosage, respectively. Mean and median infant dosage of hydromorphone were 2.1 and 0.3 mcg/kg daily, respectively. Two women excreted much more hydromorphone into their milk than the others and might represent ultrarapid CYP2D6 metabolizers. Taking the two narcotics' potencies into account, a fully breastfed neonate would receive a mean and median of 1.5 and 0.7% of the minimum infant therapeutic opiate dosage; however, neonates might be more susceptible to the opiates than the older infants on whom these dosages were based. The authors concluded that maternal dosages of hydrocodone bitartrate up to 30 to 35 mg daily are unlikely to adversely affect breastfed neonates, but that prolonged use of dosages over 40 mg daily should be avoided during breastfeeding.[2]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

The 18-day-old infant of a breastfeeding mother became groggy and "slept for most of the day" while the mother was taking 20 mg of oral hydrocodone combined with 1300 mg of acetaminophen every 4 hours for painful nipple candidiasis and mastitis. The mother decreased her dose by one-half and the infant apparently no longer experienced grogginess or hypersomnolence.[3] The infant's symptoms were probably due to the maternal hydrocodone.

A 5-week-old breastfed infant became cyanotic and required mouth-to-mouth resuscitation and intubation. The infant's urine was positive for opioids and the infant responded positively to naloxone; the level of consciousness improved over 2 days and extubation was accomplished. The infant's mother admitted to taking a hydrocodone-acetaminophen combination product and methadone that had been prescribed for migraine headache before she was breastfeeding.[4] The infant's symptoms were probably due to the maternal opiate use.

Effects on Lactation and Breastmilk

Narcotics can increase serum prolactin.[5] However, the prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Acetaminophen, Butorphanol, Hydromorphone, Ibuprofen, Morphine


1. Anderson PO, Sauberan J, Lane JR, Rossi SS. Hydrocodone excretion into breastmilk: the first two reported cases. Breastfeed Med 2007;2:10-4. PMID: 17661614

2. Sauberan JB, Anderson PO, Lane JR et al. Breast milk hydrocodone and hydromorphone levels in mothers using hydrocodone for postpartum pain. Obstet Gynecol. 2011;117:611-7. PMID: 21343764

3. Bodley V, Powers D. Long-term treatment of a breastfeeding mother with fluconazole-resolved nipple pain caused by yeast: a case study. J Hum Lact. 1997;13:307-11. PMID: 9429366

4. Meyer D, Tobias JD. Adverse effects following the inadvertent administration of opioids to infants and children. Clin Pediatr (Phila). 2005;44:499-503. PMID: 16015396

5. Tolis G, Dent R, Guyda H. Opiates, prolactin, and the dopamine receptor. J Clin Endocrinol Metab. 1978;47:200-3. PMID: 263291

Hydrocodone Identification

Substance Name


CAS Registry Number


Drug Class

Analgesics, Opioid


Antitussive Agents

Administrative Information

LactMed Record Number


Last Revision Date



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