Comparing Fluoxetine vs Venlafaxine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Fluoxetine Remove Fluoxetine from your drug comparison	Venlafaxine Remove Venlafaxine from your drug comparison	Add another drug to compare

Fluoxetine

Venlafaxine

Fluoxetine may be used for the treatment of depression and other mood disorders. It is more likely to cause insomnia than drowsiness. Prescribed for Anxiety and Stress, Major Depressive Disorder... View more

Venlafaxine is an antidepressant that may also be used for mood disorders and off-label for some other conditions such as hot flashes. It may cause a discontinuation syndrome if abruptly stopped... View more

Prescription only

Pricing and Coupons

* Prices are without insurance

Quantity	100 each
Dosage	20 mg
Per Unit^*	$0.61
Cost^*	$60.68

View all fluoxetine prices

Quantity	50 each
Dosage	150 mg
Per Unit^*	$0.79
Cost^*	$39.33

View all venlafaxine prices

Get free Discount Card

Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Oral capsule
Oral delayed release capsule
Oral solution
Oral tablet

Oral capsule, extended release
Oral tablet
Oral tablet, extended release

Brand Names

Prozac Effexor, Effexor XR

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

210 hours

4 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 637 drugs are known to interact with fluoxetine:

148 major drug interactions (567 brand and generic names)
467 moderate drug interactions (1964 brand and generic names)
22 minor drug interactions (94 brand and generic names)

A total of 645 drugs are known to interact with venlafaxine:

139 major drug interactions (556 brand and generic names)
501 moderate drug interactions (2180 brand and generic names)
5 minor drug interactions (22 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of FLUoxetine such as dizziness, drowsiness... View more

Alcohol can increase the nervous system side effects of venlafaxine such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

December 29, 1987

December 28, 1993

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer