Fentanyl Alternatives Compared
| Fentanyl | Oxycodone | Tramadol |
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| Fentanyl | Oxycodone | Tramadol |
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Prescription only
Fentanyl is a very potent pain-relieving medicine. It is not recommended for people who have never been prescribed opioid-type pain relief before, and deaths have been reported from improper dosing... View more |
Prescription only
Oxycodone is a semisynthetic opioid medication with potent pain-relieving properties that may be used to relieve severe pain that is unresponsive to less potent pain-relieving medicines (analgesics)... View more |
Prescription only
Tramadol is a strong opioid pain relieving medication that may be used to treat moderate to severe general and nerve-related pain. Tramadol may be habit-forming and misuse can cause addiction... View more |
Related suggestions Chronic Pain
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| More about Fentanyl | More about Oxycodone | More about Tramadol | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Fentanyl has an average rating of 7.8 out of 10 from a total of 433 ratings on Drugs.com. 72% of reviewers reported a positive effect, while 11% reported a negative effect. |
Oxycodone has an average rating of 6.9 out of 10 from a total of 1143 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 25% reported a negative effect. |
Tramadol has an average rating of 7.0 out of 10 from a total of 1878 ratings on Drugs.com. 62% of reviewers reported a positive effect, while 23% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
View all Fentanyl side effects |
View all Oxycodone side effects |
View all Tramadol side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Fentanyl prices |
View all Oxycodone prices |
View all Tramadol prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Actiq, Duragesic, Fentanyl Transdermal System, Fentora, Lazanda, Subsys | Dazidox, Endocodone, ETH-Oxydose, Oxaydo, OxyContin, Oxydose, Oxyfast, Roxicodone, RoxyBond, Xtampza ER View more | ConZip, Qdolo, Tramadol Hydrochloride ER | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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8.7 hours |
5.6 hours |
5.2 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
Some potential for abuse
Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category N
Not classified
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 633 drugs are known to interact with Fentanyl:
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A total of 615 drugs are known to interact with Oxycodone:
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A total of 712 drugs are known to interact with Tramadol:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||||||||||
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| First Approval Date | ||||||||||||||||||||||||||
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February 19, 1968 |
October 26, 1998 |
March 03, 1995 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
| More Information | ||||||||||||||||||||||||||
| Patient Resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.