Empagliflozin Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Empagliflozin	Mounjaro (tirzepatide)	Rybelsus (semaglutide)	Enter another drug to compare

Empagliflozin

Mounjaro (tirzepatide)

Rybelsus (semaglutide)

Prescription only

Prescribed for Chronic Kidney Disease, Heart Failure, Type 2 Diabetes, Cardiovascular Risk Reduction. Empagliflozin may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Weight Loss (Obesity/Overweight), Type 2 Diabetes. Mounjaro may also be used for purposes not listed in this medication guide.

Prescription only

Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more

More about Empagliflozin

More about Mounjaro (tirzepatide)

More about Rybelsus (semaglutide)

Ratings & Reviews

Empagliflozin has an average rating of 5.4 out of 10 from a total of 350 ratings on Drugs.com. 40% of reviewers reported a positive effect, while 41% reported a negative effect.

Mounjaro has an average rating of 8.5 out of 10 from a total of 1457 ratings on Drugs.com. 79% of reviewers reported a positive effect, while 6% reported a negative effect.

Rybelsus has an average rating of 6.5 out of 10 from a total of 315 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 22% reported a negative effect.

View all 350 reviews

View all 1457 reviews

View all 315 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Yeast infection (20.6%)
Thirst (11.1%)
Urinary tract infection (10.6%)
Frequent urination (10.3%)
Dizziness (6.3%)
Tiredness (6.3%)
Lightheadedness (6.0%)

View all Empagliflozin side effects

Nausea (16.3%)
Constipation (11.8%)
Diarrhea (8.2%)
Loss of appetite (4.7%)
Upset stomach (4.5%)
Vomiting (4.5%)
Burping (4.0%)

View all Mounjaro side effects

Nausea (40.0%)
Diarrhea (20.6%)
Constipation (17.1%)
Loss of appetite (9.2%)
Vomiting (8.3%)
Stomach pain (5.4%)
Upset stomach (5.1%)

View all Rybelsus side effects

Drug Class

SGLT-2 inhibitors

GLP-1 Agonists (Incretin Mimetics)

GLP-1 Agonists (Incretin Mimetics)

Generic Availability

N/A

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.

Quantity	2 mL
Strength	2.5 mg/0.5 mL
Per unit^*	$531.31
Cost^*	$1,062.62

View all Mounjaro prices

Quantity	30 tablet
Strength	3 mg
Per unit^*	$32.74
Cost^*	$982.34

View all Rybelsus prices

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Dosage Forms

N/A

Subcutaneous solution

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

12.4 hours

120 hours

168 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 432 drugs are known to interact with Empagliflozin:

3 major drug interactions (12 brand and generic names)
427 moderate drug interactions (1941 brand and generic names)
2 minor drug interactions (12 brand and generic names)

A total of 416 drugs are known to interact with Mounjaro:

16 major drug interactions (37 brand and generic names)
399 moderate drug interactions (2282 brand and generic names)
1 minor drug interactions (10 brand and generic names)

A total of 275 drugs are known to interact with Rybelsus:

16 major drug interactions (37 brand and generic names)
258 moderate drug interactions (1457 brand and generic names)
1 minor drug interactions (10 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more

Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases... View more
Talk to your doctor before using alcohol together with tirzepatide. Alcohol may affect blood... View more

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

Disease Interactions

First Approval Date

August 01, 2014

N/A

September 20, 2019

WADA Class View classifications

N/A

More Information

Patient Resources

Empagliflozin uses

Mounjaro uses

Rybelsus uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Empagliflozin Alternatives Compared

See also:

Wegovy

Ozempic

Mounjaro

Rybelsus

Farxiga

Jardiance

Lasix

Kerendia

Finerenone

Dapagliflozin

Further information

Empagliflozin Alternatives Compared

See also:

Further information

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