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Empagliflozin Dosage

Applies to the following strength(s): 10 mg ; 25 mg

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Diabetes Type 2

Initial dose: 10 mg orally once in the morning
Maximum dose: 25 mg orally once in the morning

-In patients tolerating the 10 mg once daily dose and requiring additional glycemic control, the dose can be increased to 25 mg once daily.
-Limitation of use: Should not be used in Type 1 diabetes mellitus or diabetic ketoacidosis
-Take with or without food

Use: An adjunct to diet and exercise to improve glycemic control in adults with Type 2 diabetes mellitus

Renal Dose Adjustments

-Severe renal impairment or end-stage renal disease: Contraindicated
-eGFR less than 45 mL/min/1.73 m2: Do not initiate therapy
-eGFR 45 mL/min/1.73 m2 or greater: No dose adjustment
-eGFR persistently less than 45 mL/min/1.73 m2: Therapy should be discontinued

Liver Dose Adjustments

No adjustment recommended


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.



Other Comments

Administration advice:
-Take orally once daily in the morning, with or without food

-After initiating therapy, monitor for signs and symptoms of hypotension and increase monitoring where volume contraction is expected.
-In patients with conditions that may lead to fluid loss, monitor volume status and electrolytes during treatment.
-Monitor renal function prior to initiating therapy, at least yearly thereafter, and prior to initiation of any concomitant medicinal product that may have a negative impact on renal function.
-Evaluate for the presence of acidosis, including ketoacidosis in symptomatic patients.

Patient advice:
-Patients experiencing symptoms of ketoacidosis such as difficulty breathing, nausea, vomiting, abdominal pain, confusion, and unusual fatigue, or sleepiness should be instructed to seek immediate medical attention.
-This drug may cause side effects such as dehydration, urinary tract infection, and yeast infections of the vagina or penis. Tell your doctor if you have any side effect that bothers you or does not go away.
-Tell your doctor about all the medications you take, including prescription and over-the-counter drugs, vitamins, dietary and herbal supplements. This drug may affect the way other medicines work, and other medicines may affect how this drug works.