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Kerendia

Generic name: finerenone
Dosage form: tablets
Drug class: Aldosterone receptor antagonists

Medically reviewed by Judith Stewart, BPharm. Last updated on Oct 1, 2021.

What is Kerendia?

Kerendia is a prescription medicine used to treat adults with chronic kidney disease associated with type 2 diabetes to reduce the risk of:

  • Worsening of kidney disease
  • End-stage kidney disease (ESKD)
  • Death due to cardiovascular disease
  • Heart attack
  • Hospitalization for heart failure

Who should not take Kerendia?

You should not take Kerendia if you:

  • Have problems with your adrenal glands
  • Take certain medications called CYP3A4 inhibitors. Ask your healthcare provider if you are not sure if you are taking any of these medications.
    • Administration of Kerendia with strong inhibitors of CYP3A4 (such as clarithromycin, itraconazole, ketoconazole, voriconazole, posaconazole, voriconazole, ritonavir, lopinavir, cobicistat) should be avoided.
    • Administration of Kerendia with moderate and weak inhibitors of CYP3A4 (such as amiodarone, erythromycin, fluconazole, diltiazem, verapamil, conivaptan) should only be used under medical supervision so that potassium levels can be monitored and dosages adjusted if needed.

Before you take Kerendia

Before you take Kerendia, tell your healthcare provider about all your medical conditions, including if you:

  • Have high potassium levels in your blood (hyperkalemia) or take medications that may increase potassium levels in your blood. Kerendia can cause hyperkalemia. Your healthcare provider will check your potassium levels before and during treatment.
  • Have severe liver problems.
  • Are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Avoid breastfeeding during treatment and one day after treatment is stopped.

Tell your healthcare provider about all the prescription and over-the-counter medicines you take, including: salt substitutes, vitamins, and herbal or potassium supplements.

Kerendia may affect the way other medications work, and other medications may affect how Kerendia works. Do not start or stop any medicine before you talk with your healthcare provider. Avoid grapefruit or grapefruit juice as it may increase Kerendia levels in the blood.

How should I take Kerendia?

  • Take Kerendia exactly as your healthcare provider tells you to take it.
  • Take the tablets by mouth with or without food.

Kerendia side effects

The most common side effects include:

  • Hyperkalemia (potassium level in your blood that is higher than normal)
  • Hypotension (blood pressure that is lower than normal) 
  • Hyponatremia (sodium level in your blood that is lower than normal)

These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA1088.

What other drugs will affect Kerendia?

Many drugs can interact with finerenone, and some drugs should not be used at the same time. Tell your doctor about all other medicines you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

How should I store Kerendia?

Store Kerendia at room temperature between 68°F to 77°F (20°C to 25°C).

General information about the safe and effective use of Kerendia.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet.
Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information that is written for health professionals.

What are the ingredients in Kerendia?

Active ingredient: finerenone

Inactive ingredients: lactose monohydrate, cellulose microcrystalline, croscarmellose sodium, hypromellose, magnesium stearate, and sodium lauryl sulfate.
The film coating contains hypromellose, titanium dioxide and talc, in addition to ferric oxide red (10 mg strength tablets) or ferric oxide yellow (20 mg strength tablets).

 

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.