Kerendia Dosage

Generic name: FINERENONE 10mg
Dosage form: tablet, film coated
Drug class: Aldosterone receptor antagonists

Medically reviewed by Drugs.com. Last updated on Aug 22, 2024.

Prior to Initiation of Kerendia

Measure serum potassium levels and estimated glomerular filtration rate (eGFR) before initiation. Do not initiate treatment if serum potassium is > 5.0 mEq/L.

Recommended Starting Dosage

The recommended starting dose of Kerendia is based on eGFR and is presented in Table 1.

Table 1: Recommended Starting Dosage
eGFR (mL/min/1.73m2)	Starting Dose
≥ 60	20 mg once daily
≥ 25 to < 60	10 mg once daily
< 25	Initiation is not Recommended

For patients who are unable to swallow whole tablets, Kerendia may be crushed and mixed with water or soft foods such as applesauce immediately prior to use and administered orally.

Monitoring and Dose Adjustment

The target daily dose of Kerendia is 20 mg.

Measure serum potassium 4 weeks after initiating treatment and adjust dose (see Table 2); if serum potassium levels are > 4.8 to 5.0 mEq/L, initiation of Kerendia treatment may be considered with additional serum potassium monitoring within the first 4 weeks based on clinical judgment and serum potassium levels. Monitor serum potassium 4 weeks after a dose adjustment and throughout treatment, and adjust the dose as needed (see Table 2).

Table 2: Dose Adjustment Based on Current Serum Potassium Concentration and Current Dose
		Current Kerendia Dose
		10 mg once daily	20 mg once daily
Current Serum Potassium (mEq/L)	≤ 4.8	Increase the dose to 20 mg once daily.*	Maintain 20 mg once daily.
	> 4.8 – 5.5	Maintain 10 mg once daily.	Maintain 20 mg once daily.
	> 5.5	Withhold Kerendia. Consider restarting at 10 mg once daily when serum potassium ≤ 5.0 mEq/L.	Withhold Kerendia. Restart at 10 mg once daily when serum potassium ≤ 5.0 mEq/L.

* If eGFR has decreased by more than 30% compared to previous measurement, maintain 10 mg dose.

Missed doses

Direct a patient to take a missed dose as soon as possible after it is noticed, but only on the same day. If this is not possible, the patient should skip the dose and continue with the next dose as prescribed.