Kerendia Dosage
Generic name: FINERENONE 10mg
Dosage form: tablet, film coated
Drug class: Aldosterone receptor antagonists
Medically reviewed by Drugs.com. Last updated on Jul 29, 2025.
Prior to Initiation of Kerendia
Measure serum potassium levels and eGFR before initiation. Do not initiate treatment if serum potassium is > 5.0 mEq/L.
Recommended Starting Dosage
The recommended starting dose of Kerendia is based on eGFR and is presented in Table 1.
| eGFR (mL/min/1.73m2) | Starting Dose |
|---|---|
| ≥ 60 | 20 mg orally once daily |
| ≥ 25 to < 60 | 10 mg orally once daily |
| < 25 | Initiation is not recommended |
For patients who are unable to swallow whole tablets, Kerendia may be crushed and mixed with water or soft foods such as applesauce immediately prior to use and administered orally.
Monitoring and Dosage Adjustment
CKD associated with T2DM
The target daily dose of Kerendia is 20 mg orally.
Measure serum potassium 4 weeks after initiating treatment and adjust dose (see Table 2); if serum potassium levels are > 4.8 to 5.0 mEq/L, initiation of Kerendia treatment may be considered with additional serum potassium monitoring within the first 4 weeks based on clinical judgment and serum potassium levels. Measure serum potassium 4 weeks after a dose adjustment and periodically throughout treatment, and adjust the dose as needed (see Table 2).
| Current Kerendia Dose | |||
|---|---|---|---|
| 10 mg once daily | 20 mg once daily | ||
|
|||
| Current Serum Potassium (mEq/L) | ≤ 4.8 | Increase the dose to 20 mg once daily.* | Maintain 20 mg once daily. |
| > 4.8 – 5.5 | Maintain 10 mg once daily. | Maintain 20 mg once daily. | |
| > 5.5 | Withhold Kerendia. Consider restarting at 10 mg once daily when serum potassium ≤ 5.0 mEq/L. |
Withhold Kerendia. Restart at 10 mg once daily when serum potassium ≤ 5.0 mEq/L. |
|
Heart Failure with LVEF ≥ 40%
The target daily dose of Kerendia for heart failure (LVEF ≥ 40%) is dependent on renal function (eGFR) at initiation of Kerendia treatment (see Table 3).
- The target daily dose is 40 mg orally once daily if eGFR at initiation is ≥ 60 mL/min/1.73m2.
- The target daily dose is 20 mg orally once daily if eGFR at initiation is ≥ 25 to < 60 mL/min/1.73m2.
Measure serum potassium and eGFR 4 weeks after initiating treatment and adjust dose (see Table 3). Measure serum potassium and eGFR 4 weeks after a dose adjustment and monitor periodically throughout treatment, and adjust the dose as needed (see Table 3).
| Current Kerendia Dose | ||||
|---|---|---|---|---|
| 10 mg once daily | 20 mg once daily | 40 mg once daily | ||
| Current Serum Potassium (mEq/L) |
< 5.0 | Increase the dose to 20 mg once daily* | Maintain 20 mg once daily if eGFR < 60 mL/min/1.73 m2 at initiation. Otherwise increase the dose to 40 mg once daily* |
Maintain 40 mg once daily. |
| ≥ 5.0 to < 5.5 | Maintain current dose. | |||
| ≥ 5.5 to < 6.0 | Withhold Kerendia. Restart at 10 mg once daily when serum potassium < 5.5 mEq/L. |
Decrease to 10 mg once daily. | Decrease to 20 mg once daily. | |
| ≥ 6.0 | Withhold Kerendia. Restart at 10 mg once daily when serum potassium < 5.5 mEq/L.† |
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