Comparing Duloxetine vs Zoloft
| Duloxetine Remove Duloxetine from your drug comparison | Zoloft Remove Zoloft from your drug comparison |
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| Duloxetine Remove Duloxetine from your drug comparison | Zoloft sertraline Remove Zoloft from your drug comparison | ||||||||||||||||
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Duloxetine has antidepressant, anti-anxiety, and pain-relieving properties; however, it may cause a discontinuation syndrome on withdrawal even when tapered. Prescribed for Chronic Pain, Back Pain,... View more |
Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants. Prescribed for Panic Disorder, Obsessive Compulsive Disorder, Major Depressive Disorder,... View more |
Choose a suggestion below Depression
Major Depressive Disorder
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Prescription only |
Prescription only |
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Ratings & ReviewsRecent helpful reviews |
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6.3
For Depression: I recently reviewed this drug and gave it a 9/10 after 3 months. I thought that I had found what I had been looking for. Unfortunately, a month later my mood started to dip and the lethargy, that came with depression, never lifted. It still helped significantly more that the SSRIs that I’ve tried, but it isn’t quite right for me. That being said, it was very effective for my anxiety. Depression - not so much. |
7.3
For Depression: Hi everyone, I am glad to find a place that I can tell my story & maybe get some opinions. I started taking Zoloft when my husband of 53 years passed, that was 3 years ago. I had the doctor give me instructions on weaning from it in November. So now it has been 8 days off. I did not have any side effects until today. After I got home from church I just broke out in tears & I am not a crier. Is it normal to get this effect after 8 days off? I really would like to stay off the med. Thanks For Depression: Just take these reviews with a grain of salt. A lot of reviews after taking one day, couple weeks etc. you need a full three months for maximum effectiveness. Not that it takes that long to start getting relief. Side effects are common while your body adjusts. Some of them will go away. I had no troublesome side effects with Zoloft. I always have to start out gradually. Maybe even more than they say bc I’m sensitive to meds. I got big relief from depression. Panic attacks went away. OCD went away. The cons are it made me not very motivated, felt kind of numb to strong feelings. Not feeling urgency about my life. I wouldn’t take it again for years bc it blocked my clear perspective. But it was great to get me stabilized. Things that really help but can’t completely replace anti dep is fish oil, vit d, exercise, sunlight, folate like spinach , lentils really good. Also diet really helps. Get a book called the good mood diet. Best wishes |
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Drug Class |
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Side Effects |
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Commonly reported side effects include: asthenia, constipation, diarrhea, dizziness, drowsiness, fatigue, hypersomnia, insomnia, nausea, sedated state, headache, and xerostomia. See the full duloxetine side effects document. |
Common side effects include: diarrhea, dizziness, drowsiness, dyspepsia, fatigue, insomnia, loose stools, nausea, tremor, headache, paresthesia, anorexia, decreased libido, delayed ejaculation, diaphoresis, ejaculation failure, and xerostomia. See the full Zoloft side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all duloxetine prices |
View all Zoloft prices and generic prices |
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Generic Availability |
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Yes (this medicine) |
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Dosage Form(s) Available |
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Brand Names |
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| Cymbalta, Drizalma Sprinkle, Irenka |
N/A |
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Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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17 hours |
66 hours |
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CSA Schedule**View glossary of terms. |
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
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FDA Alerts |
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Drug Interactions |
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A total of 558 drugs are known to interact with duloxetine:
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A total of 610 drugs are known to interact with Zoloft:
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Alcohol/Food/Lifestyle Interactions |
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Disease Interactions |
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First Approval Date |
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August 03, 2004 |
December 30, 1991 |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Depression: I've been on duloxetine for over a year. While it has helped my anxiety and depression it doesn't help my pain at all. Or my urinary issues which I know it is known to help also. I feel drained all the time so it hasn't helped that at all. I'm just so freaking tired. :'( idk probably not for me I don't think. Surely I shouldn't be this tired.