Comparing Duloxetine vs Zoloft

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Duloxetine

Zoloft sertraline

Duloxetine has antidepressant, anti-anxiety, and pain-relieving properties; however, it may cause a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain, Chronic Pain... View more

Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants. Prescribed for Panic Disorder, Obsessive Compulsive Disorder, Major Depressive Disorder... View more

Prescription only

Ratings & Reviews

View all 2129 reviews

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Drug Class

Serotonin-norepinephrine reuptake inhibitors

Selective serotonin reuptake inhibitors

Side Effects

Commonly reported side effects include: asthenia, constipation, diarrhea, dizziness, drowsiness, fatigue, hypersomnia, insomnia, nausea, sedated state, headache, and xerostomia.

See the full duloxetine side effects document.

Common side effects include: diarrhea, dizziness, drowsiness, dyspepsia, fatigue, insomnia, loose stools, nausea, tremor, headache, paresthesia, anorexia, decreased libido, delayed ejaculation, diaphoresis, ejaculation failure, and xerostomia.

See the full Zoloft side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	30 each
Dosage	30 mg
Per Unit^*	$2.75
Cost^*	$82.38

View all duloxetine prices

Quantity	30 tablet
Dosage	100 mg
Per Unit^*	$13.13
Cost^*	$393.84

View all Zoloft prices and generic prices

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Generic Availability

Yes (this medicine)

Yes

Dosage Form(s) Available

Oral delayed release capsule

Oral concentrate
Oral tablet

Brand Names

Cymbalta, Drizalma Sprinkle, Irenka Other sertraline brands include: Zercapli

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

17 hours

66 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 565 drugs are known to interact with duloxetine:

101 major drug interactions (451 brand and generic names)
441 moderate drug interactions (1922 brand and generic names)
23 minor drug interactions (181 brand and generic names)

A total of 625 drugs are known to interact with Zoloft:

144 major drug interactions (566 brand and generic names)
475 moderate drug interactions (1960 brand and generic names)
6 minor drug interactions (26 brand and generic names)

Alcohol/Food/Lifestyle Interactions

DULoxetine may cause liver damage, and taking it with alcohol may increase that risk. You should... View more

You should avoid or limit the use of alcohol while being treated with sertraline. Alcohol can... View more

Disease Interactions

First Approval Date

August 03, 2004

December 30, 1991

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Professional Resources

Prescribing Information

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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