Comparing Doxepin vs Nortriptyline

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Doxepin	Nortriptyline	Enter another drug to compare

Doxepin

Nortriptyline

Prescription only

Doxepin may be used to treat symptoms associated with anxiety or depression such as fear, guilt, sleep disturbances, tension, and worry. It is devoid of any euphoric effect and not associated with... View more

Prescription only

Nortriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions, such as... View more

More about Doxepin

More about Nortriptyline

Ratings & Reviews

Doxepin has an average rating of 6.2 out of 10 from a total of 433 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 34% reported a negative effect.

Nortriptyline has an average rating of 7.3 out of 10 from a total of 568 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 19% reported a negative effect.

View all 433 reviews

View all 568 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Drowsiness (15.5%)
Weight gain (7.6%)
Tiredness (6.7%)
Anxiety (6.0%)
Dry mouth (5.5%)
Depression (4.4%)
Brain fog (3.7%)

View all Doxepin side effects

Dry mouth (14.4%)
Constipation (7.4%)
Drowsiness (5.6%)
Insomnia (5.5%)
Weight gain (5.5%)
Headaches (5.3%)
Dizziness (5.1%)

View all Nortriptyline side effects

Drug Class

Tricyclic antidepressants

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	100 each
Strength	50 mg
Per unit^*	$0.93
Cost^*	$92.60

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Quantity	50 each
Strength	25 mg
Per unit^*	$0.61
Cost^*	$30.65

View all Nortriptyline prices

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Dosage Forms

Oral capsule
Oral concentrate
Oral tablet

Oral capsule
Oral solution

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

25 hours

31 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category N Not classified

See the full pregnancy warnings document.

Category N Not classified

See the full pregnancy warnings document.

Drug Interactions

A total of 704 drugs are known to interact with Doxepin:

143 major drug interactions (604 brand and generic names)
537 moderate drug interactions (2167 brand and generic names)
24 minor drug interactions (157 brand and generic names)

A total of 702 drugs are known to interact with Nortriptyline:

143 major drug interactions (604 brand and generic names)
535 moderate drug interactions (2165 brand and generic names)
24 minor drug interactions (157 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using doxepin together with alcohol, this can alter the effects of doxepin... View more

Ask your doctor before using nortriptyline together with alcohol, this can alter the effects of... View more

Disease Interactions

First Approval Date

September 23, 1969

November 06, 1964

WADA Class View classifications

N/A

More Information

Patient Resources

Nortriptyline uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Doxepin vs Nortriptyline

See also:

Xolair

Auvelity

Vraylar

Ativan

Benadryl

Ambien

Lunesta

Ramelteon

Eszopiclone

Temazepam

Further information

Comparing Doxepin vs Nortriptyline

See also:

Further information

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