Comparing Benadryl vs Dextromethorphan
| Benadryl (diphenhydramine) | Dextromethorphan |
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| Benadryl (diphenhydramine) | Dextromethorphan |
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Prescription and OTC
Benadryl is used to treat allergies, motion sickness, and to relieve symptoms of Parkinson's Disease (PD) in patients unable to tolerate more potent agents. It may also be used off-label to help... View more |
Prescription and OTC
Prescribed for Cough. Dextromethorphan may also be used for purposes not listed in this medication guide. |
Related suggestions |
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| More about Benadryl (diphenhydramine) | More about Dextromethorphan | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Benadryl has an average rating of 7.0 out of 10 from a total of 80 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 20% reported a negative effect. |
Dextromethorphan has an average rating of 3.7 out of 10 from a total of 388 ratings on Drugs.com. 20% of reviewers reported a positive effect, while 62% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Benadryl side effects |
View all Dextromethorphan side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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N/A |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Benadryl prices |
View all Dextromethorphan prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep Tablets, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | 12 Hour Cough Relief, Babee Cof, Balminil DM, Benadryl for the Family Dry Forte, Benylin DM, Bisolvon Dry, Bisolvon Dry Junior, Buckley's DM, Buckley's Mixture Cough Suppressant, Buckleys Mixture, Calmylin, Contac Cough, Cough Syrup DM, Covonia Bronchial Balsam, Creomulsion, Creomulsion Children, Delsym, Delsym 12 Hour Cough Relief, Delsym 12 Hour Cough Relief for Children & Adults, Delsym Children's 12-Hour Cough Relief, DexAlone, Dexi-Tuss, Dextromethorphan HBr Adult Formula, Dristan DM, Dry Cough, Duract Max Strength Cough, ElixSure Cough, Giltuss Children's Honey DM 8hr Cough, Giltuss Honey DM 8hr Cough, Hold, Hold DM, Robafen Cough Liquidgels, Robitussin 12-Hour Cough Relief, Robitussin Children's Cough Long-Acting, Robitussin Cough Long-Acting, Robitussin CoughGels Long-Acting, Robitussin Direct Cough, Scot-Tussin Diabetes, Silphen DM, Sucrets Cough, Triaminic Long Acting Cough, Triaminic Thin Strips Cough, Tussin Cough Gels (Long Acting), Vicks Dayquil Cough, Vicks Formula 44, Vicks Formula 44 Custom Care Dry Cough Suppressant, Vicks Nature Fusion Cough View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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9.3 hours |
3.6 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 449 drugs are known to interact with Benadryl:
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A total of 369 drugs are known to interact with Dextromethorphan:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
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No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| First Approval Date | |||||||||||||||||
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March 04, 1946 |
October 08, 1982 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.