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Dextromethorphan Drug Interactions

A total of 619 drugs are known to interact with dextromethorphan.

  • 99 major drug interactions
  • 517 moderate drug interactions
  • 3 minor drug interactions

Show all medications in the database that may interact with dextromethorphan.

Check for interactions with dextromethorphan

Type in a drug name and select a drug from the list.

Common medications checked in combination with dextromethorphan

  • acetaminophen (Tylenol, Paracetamol, Mapap, Panadol, Tylenol Arthritis Pain, Tylenol Extra Strength, Ofirmev, Children's Tylenol, Dafalgan, Paracetamol Almus, Perfalgan, Tempra, Doliprane, Paracetamol Teva, Panadol Osteo, Arthritis Pain Relief, Aceta, Tactinal, Cipla Genpharm Paracetamol, Alvedon, Panadol ActiFast, Tylenol 8 Hour, Panadol Extend, Efferalgan, Paracetamol Arrow, Liquiprin, Infant's Tylenol, Aminofen, Miradol, Panamax, Paracare, Priceline Paracetamol, Tylophen, Abenol, Febrol Solution, Pharmacy Health Own Name Paracetamol for Children, Little Fevers, Pharbetol, Q-Nol, Pain-Eze, Actamin, DG Health Pain Reliever, Paracetamol Sandoz, Tycolene, Perfalgan Nourrissons Et Enfants, Calpol Infant, Calpol Paediatric, Cetafen, Calpol Fastmelts, Mandanol, Valorin, Remedol, Promax, API Healthcare Paracetamol, Terry White Chemists Paracetamol, Pharmacist Advice Paracetamol, Terry White Chemists Paracetamol Colourfree Children 5-12 Years, Tylenol Childrens Paracetamol, Conney Aspirin-Free, Panadol Gel Caps, Pacimol Caplets, Pharmore Paracetamol, Basics Paracetamol, Genapap, Sigma Pain Relief, Pain Clear Paracetamol, Setamol, Paraspen Drops, Panadol Colourfree Drops, Pharmacist Paracetamol Infant Drops, Pharmacist Paracetamol Infant Drops Colour Free, Bi-Lo Paracetamol, Pain-Eze Paracetamol Infant Drops Colour Free, Pharmaction Paracetamol, Biochemie Paracetamol, Healthsense Pain Relief Drops Children 1 Month to 2 Years, Black And Gold Paraceatmol, Pharmacist Advice Paracetamol Infant Drops, Black and Gold Paracetamol, Hexal Comfarol, Blooms the Chemist Paracetamol, Paracetamol Soluble, Vitapap, Bristol Pharma Paracetamol, Sigma Paracetamol, Actimol Infant, ConRx Extra Strength, PediaCare Infants' Acetaminophen Fever Reducer/Pain Reliever, PediaCare Children's Acetaminophen Fever Reducer/Pain Reliever, Pharmacy Health Paracetamol Colour Free Childrens, PediaCare Smooth Melts Acetaminophen Fever Reducer/Pain Reliever, Pharmacy Health Paracetamol Colour Free Infants and Childrens Drops 1 Month-4 Years, Altenol, Mapap Children's, Capital Chemist Paracetamol, Lemsip Cold and Flu Liquid Capsule, Children's Silapap, Febridol Infant Drops, Accidental Rapatabs, Chem Mart Chemadol Children 1 to 5 Years, Chem Mart Chemadol Colourfree, Chem Mart Chemadol Colourfree Children 5-12 Years, Chemists Own Chiildrens Paracetamol 5-12 Years, Lemsip Headcold, Chemists Own Childrens Paracetamol 1-5 Years, Lemsip Max, Chemists Own Paracetamol, Lemsip Original, Chemists Own Paracetamol Capseals, Chemists Own Paracetamol Pain & Fever 1 Month to 2 Years, Chemists Own Paracetamol Pain & Fever 1 to 5 Years, Chemists Own Paracetamol Pain and Fever 5 to 12 Years, A-Pak Laboratories Paediatric Analgesic Paracetamol, Chemplus Paracetamol, Chemworld Colourfree Childrens Paracetamol Double Strength 5-12 Years, Chemworld Colourfree Childrens Paracetamol Junior 1-5 Years, Chemworld Paracetamol, Chemworld Paracetamol Infant Colour Free, HyVee Health 8 Hour Pain Relief, Bydol, Chem Mart Chemadol, Leader 8 Hour Pain Reliever, Children's ElixSure, Mapap Rapid Release Gelcaps, Benylin Sore Throat, Fawns & McAllan Paracetamol, Zee Unaspirin ES, Chem Mart Chemadol Colourfree Childrens 1-5 Years, Midol Long Lasting Relief, Childrens Panadol 1 - 5 Years Colourfree, Childrens Panadol 1 - 5 Years, Childrens Panadol 5 - 12 Years Colourfree, Childrens Panadol 5 - 12 Years, Equaline Pain Relief, Help I Have A Headache, Febridol Clear Effervescent, Herron Paracetamol Tabsules, Panadol Rapid Handipak, Panadol Soluble, Paralgin Paracetamol Tabsules, Pharmacist Childrens Paracetamol Colourfree 1-5 Years, Pharmacist Childrens Paracetamol Colourfree 5-12 Years, Pharmacy Health Colour Free Childrens Paracetamol, Gold Cross Paracetamol, Tylenol Cold Sore Throat, Alpha First Aid Supplies Paracetamol, Guardian Childrens Paracetamol 5-12 Years, Guardian Paracetamol, Guardian Paracetamol Tabsules, Acephen, Rex Paracetamol, Feverall, Topcare Arthritis Pain Relief, Accidental First Aid Supplies Paracetamol, Panadol Childrens, Panadol Jr, Flu Strength Hot Lemon Powders, Paineze Paracetamol, Health Care Chemist Paracetamol Infant Drops Colour Free, Genebs, Buckley's Complete, Herron Gold Paracetamol Tabsules, Tylenol Regular Strength, Panamol, Herron Paracetamol, Tempra 2, Tempol, Herron Paracetamol Capseals, Tempra 3, Taminol, Herron Paracetamol Capseals Handy Pack, Herron Paracetamol Handy Pack, Apra, Claradol, Anacin Aspirin Free, Conacetol, Dolono, Doliprane Adultes, Coles Paracetamol, Genapap Extra Strength, Doliprane Sans Sucre, Dolitabs, Home Brand Paracetamol, Q-Pap Extra Strength, Dolko, ICN Paracetamol, Redutemp, Dolko Enfants, Dolotec, Vicks Formula 44 Custom Care Body Aches, James Dean Pharmacy Paracetamol, Efferalgan Pediatrique, Uniserts, Efferalganodis, Silapap Childrens, Expandox, Dolono Infant, Geluprane, Paracetamol Biogaran, Ed-APAP, Paracetamol EG, St. Joseph Aspirin-Free, Country Chemists Paracetamol, Paracetamol Ivax, Paracetamol Merck, Paracetamol Qualimed, Paracetamol Ranbaxy, Adprin B, BF-Paradac, Paracetamol RPG, Tempra Quicklets, Paracetamol Sandoz Conseil, Lloydspharmacy Paracetamol Six Plus, Q-Pap, Paracetamol Winthrop, Triaminic Fever Reducer Pain Reliever, Lloydspharmacy Paracetamol Infant, Atasol, Paracetamol Zydus, Triaminic Infant Drops, Atasol Forte, Paralyoc, Tylenol Cool Caplet Extra Strength, Acetaminophen-odan, Mapap Rapid Tabs, Jr. Tylenol, Mapap Extra Strength Rapid Burst, Elixsure Fever/Pain, Infadrops, Disprol Soluble Paracetamol, Disprol Paracetamol, Galpamol, Paldesic, Medinol Paediatric, Medinol Under 6, Infantaire Drops, Lemsip Pharmacy Non-Decongestant Formula, Calpol Six Plus, Masophen, Medinol Over 6, Nortemp Children's, Paracets, Anadin Paracetamol, Hedex, UN-Aspirin Extra Strength, Actimol Children's, Dakota Paracetamol, Umphamol, Panamax 240, Paralgin, Parahexal, Febridol, Mid West Products Numol Paracetamol, Parmol, Silapap Infants, Cuprofen for Children, Mapap Infant Drops, Mandanol Infant, Cetafen Extra, Mandanol 6+, Lemsip Childrens Cold & Flu, Fennings Childrens Cooling, Duatrol SR, Aldi Hedanol Paracetamol, Under Ten Care Infant, Alphapharm Paracetamol, Amadol Paracetamol, No Frills Paracetamol, Tylenol Sore Throat Daytime, Nova Paracetamol, Mapap Meltaway, Numark Paracetamol, Amcal Childrens Paracetamol 1-5 Years, Nyal Paracetamol, Medi-Tabs, Amcal Childrens Paracetamol 5-12 Years, Orajel Maximum Strength Toothache, Mapap Arthritis Pain, Amcal Paracetamol Pain Relief, Ordov Febrigesic Paracetamol, Topcare 8 Hour Pain Relief, Amcal Paracetamol Infant Drops 1 Month to 2 Years, Pain-Eze Paracetamol Infant Drops, Febridol Syrup for Children, Amcal Paracetamol Tabsules, Pharmacist Advice Colourfree Childrens Paracetamol Double Strength, Guardian Childrens Paracetamol, Pharmacist Formula Paracetamol, Pharmacist Formula Infants, Paraspen, RP Scherer Paracetamol, RP Scherer Paracetamol Liquid-Filled Capsules, Savings Paracetamol, Signature Range Paracetamol, Dymadon, Soul Pattinson Childrens Paracetamol Elixir, Soul Pattinson Colour Free Paracetamol 1-5 Years, Soul Pattinson Colour Free Paracetamol Drops, Soul Pattinson Colourfree Childrens Paracetamol, Panadol Gel Tabs, API Healthcare Coloufree Childrens Paracetamol, Soul Pattinson Paracetamol, API Healthcare Colourfree Childrens Paracetamol Double Strength, Soul Pattinson Paracetamol Clear Effervescent, Panadol Mini Caps, Pharmacy Health Paracetamol, Terry White Chemists Colour Free Paracetamol 1-5 Years, Pharmacist Paracetamol, Terry White Chemists Colour Free Paracetamol Infant Drops)
  • Adderall (amphetamine / dextroamphetamine)
  • Alcohol (contained in alcoholic beverages) (ethanol)
  • Aspirin Low Strength (aspirin)
  • azithromycin (Zithromax, Azithromycin Dose Pack, Z-Pak, Zmax)
  • Benadryl (diphenhydramine)
  • benzonatate (Tessalon Perles, Tessalon, Zonatuss)
  • Claritin (loratadine)
  • codeine
  • Cymbalta (duloxetine)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Diphenhist, Diphen, Unisom SleepGels, Sleep, Diphen Cough, Hydramine, Benadryl Children's Allergy, Sominex, Diphenadryl, Dicopanol, Diphedryl, Diphenydramine Quick Melt, Nytol, Buckley's Bedtime, 40 Winks, DPH, Q-Dryl, Sleep-Eze-3, Valu-Dryl, Diphenyl, Beldin, Vicks QlearQuil Nighttime Allergy Relief, Sleep-ettes, Allermax, Diphendryl, Q-Dryl A/F, Histaprin, Tranquil Nighttime Sleep Aid, Dormin, Sleepwell 2-nite, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Hyrexin, Hydramine Cough Syrup, Bydramine, Diphen AF, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Calm-Aid, Genahist, Alka-Seltzer Plus Allergy, Aller-G-Time, Sleep Tab II, Sleep Tabs, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Altaryl, Triaminic Thin Strips Cough & Runny Nose, Belix, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Quenalin, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Pharbedryl, Z-Sleep, Unisom SleepMelts, PediaCare Children's Allergy, Truxadryl, Simply Sleep, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flonase (fluticasone nasal)
  • guaifenesin (Mucinex, Tussin, Robafen, Robitussin Chest Congestion, Humibid, Guaifenesin LA, Guaiatussin, Guiatuss, Siltussin, Guaifenex LA, Tussin Expectorant, Fenesin, Guaifenex G, Mucus Relief, Organ-1 NR, Liquibid, Breonesin, GG 200 NR, Glytuss, Mytussin, Q-Tussin, Sorbutuss, Robitussin Mucus + Chest Congestion, Diabetic Tuss, Balminil Expectorant, Xpect, Strepsils Chesty Cough, Kenkay Chesty Cough Eexpectorant, Liquituss GG, Siltussin DAS, Organidin NR, Benadryl Chesty Forte, G Bid, Touro EX, Pneumomist, Ganidin NR, Iofen-NF, Humibid Pediatric, Iodrol NR, Mucinex Children's Chest Congestion, Guaibid-LA, Aquamist, Q-Bid LA, Amibid LA, Mucobid-LA, Fenex-LA, Muco-Fen LA, Muco-Fen 800, Scot-Tussin Expectorant, Humavent LA, Guiacough, Lotussin, Altarussin, Anti-Tuss, Diabetic Expectorant, Allfen Jr, Genatuss, Halotussin, Mastussin, Ri-Tussin, Robichem, Siltuss DAS, T-Tussin, Tusscidin, Gua-SR, Humigen LA, Sinumist, Altorant, Duratuss G, Naldecon-EX Senior, Phanasin, Iophen NR, GG-Cen, Muco-Fen 1200, Liquidbid LA, Liquidbid 1200, Benylin E, Calmylin Expectorant, Guiadrine G-1200, Siltussin DAS-NA, Iofen, Muco-Fen, Drituss G, Beechams Veno's for Kids Chesty Cough, Junior Meltus Colour and Sugar Free Expectorant, Help I Have Chest Congestion, Tixylix Chesty Cough, Bidex-400, Humibid E, Fenesin IR, Hill's Balsam Chesty Cough, Jackson's Extra Strength All Fours, Junior Meltus Chesty Coughs with Catarrh, Liqufruta Garlic Cough Medicine, Family Meltus Chesty Coughs, Jackson's The Original All Fours, Beechams Veno's Expectorant, Lemsip Cough Chesty, Respa-GF, Nirolex Chesty Cough, Dristan Chesty Cough, Nyal Chesty Cough, Pharmacist Expectorant, Dristan Chesty Cough Guaiphenesin, Mucinex for Kids, Guaifen NR, Buckley's Chest Congestion, Lloydspharmacy Expectorant Adult Cough, Lloydspharmacy Expectorant Junior Cough, TabTussin 400, Diabetic Tussin Mucus Relief, Refenesen Chest Congestion Relief, Bronchoril, Hytuss, Actifed CC Chesty Cough, Mucaplex, Tussin Mucus + Chest Congestion, Air Power, Mucinex Maximum Strength)
  • ibuprofen (Advil, Motrin, IBU, Proprinal, Advil Liqui-Gels, Motrin IB, IBU-200, Nuprin, Advil Infant's Concentrated Drops, Children's Motrin, Advil Children's, Ibu-8, Ibuprofen PMR, Caldolor, Motrin Childrens, Motrin Migraine Pain, Addaprin, Ibu-4, Ibu-Tab, Rufen, Midol IB, A-G Profen, Childrens Ibuprofen Berry, Advil Migraine, Ibu-6, Motrin Infant Drops, NeoProfen, Genpril, Haltran, Menadol, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • Lexapro (escitalopram)
  • loratadine (Claritin, Alavert, Allergy Relief Tablets, Claritin 24 Hour Allergy, Loratadine Reditab, Claritin Reditabs, Wal-itin, Help I Have Allergies, Children's Claritin Allergy, Allergy Relief 24 Hour, Children's Allergy Relief 24 Hour, Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief, ohm Allergy Relief, Clear-Atadine, Claritin Hives Relief, Dimetapp Children's ND Non-Drowsy Allergy, Clear-Atadine Children's, Bactimicina Allergy, Tavist ND)
  • Lyrica (pregabalin)
  • Mucinex (guaifenesin)
  • Neosporin (bacitracin / neomycin / polymyxin b topical)
  • Orajel (benzocaine topical)
  • Paracetamol (acetaminophen)
  • phenylephrine (Neo-Synephrine, Sudafed PE Congestion, Phenyl-T, Nasal Decongestant PE, Congest Aid II, Nasop, Vazculep, Suphedrine PE, Help I Have A Stuffy Nose, Despec-SF, Sudogest PE, Nasop12, Triaminic Thin Strips Cold with Stuffy Nose, Dimetapp Toddler's Drops Decongestant, AH-Chew D, Gilchew IR, Little Colds Decongestant, Lusonal, Contac-D, Ricobid-D, PediaCare Children's Decongestant, Sudafed PE Children's Nasal Decongestant)
  • pseudoephedrine (Sudafed Congestion, SudoGest, Sudafed 12-Hour, Entex, Efidac, Silfedrine, Suphedrine, Chlor-Trimeton Nasal Decongestant, Nexafed Nasal Decongestant, nasofed, Suphedrin, ElixSure Congestion, Children's Dimetapp Decongestant Infant, Allermed, Novafed, Cenafed, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Afrinol, Zephrex-D, Sudafed Children's Nasal Decongestant, Decofed Liquid, Decofed, Kid Kare Drops, Myfedrine, Sudodrin, Elixsure Decongestant, Unifed, Sudafed 24-Hour, Contac Cold, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant)
  • quinidine (Quinora, Quinidex Extentabs, Cardioquin, Quinaglute Dura-Tabs, Quin-Release, Quin-G)
  • Singulair (montelukast)
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zoloft (sertraline)
  • Zyrtec (cetirizine)

dextromethorphan alcohol/food Interactions

There is 1 alcohol/food interaction with dextromethorphan

dextromethorphan disease Interactions

There is 1 disease interaction with dextromethorphan:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

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