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Dextromethorphan Drug Interactions

A total of 622 drugs are known to interact with dextromethorphan.

  • 99 major drug interactions
  • 520 moderate drug interactions
  • 3 minor drug interactions

Show all medications in the database that may interact with dextromethorphan.

Check for interactions

Type in a drug name to check for interactions with dextromethorphan.

Most frequently checked interactions

View interaction reports for dextromethorphan and the medicines listed below.

  • acetaminophen (Tylenol, Paracetamol, Panadol, Mapap, Tylenol Arthritis Pain, Tylenol Extra Strength, Ofirmev, Children's Tylenol, Arthritis Pain Relief, Perfalgan, Doliprane, Efferalgan, Paracetamol Teva, Tempra, Cipla Genpharm Paracetamol, Dafalgan, Tactinal, Altenol, Feverall, Panadol ActiFast, Panamax, Panadol Osteo, Mapap Arthritis Pain, Panadol Extend, Lemsip Max, Paracetamol Almus, Paracetamol Ranbaxy, Promax, Tylenol 8 Hour, Aceta, Acephen, Dolono, Infant's Tylenol, Calpol Paediatric, Cetafen, Panadol Gel Tabs, Setamol, Blooms the Chemist Paracetamol, Panadol Childrens, Buckley's Complete, Pharbetol, Doliprane Adultes, Efferalgan Pediatrique, Paracetamol Ivax, Actamin, BF-Paradac, Paracetamol Sandoz Conseil, Tycolene, Q-Pap, Atasol, Triaminic Infant Drops, Mapap Extra Strength Rapid Burst, Disprol Soluble Paracetamol, Calpol Infant, Alvedon, Calpol Fastmelts, Aminofen, Anadin Paracetamol, Hedex, Valorin, Parmol, Orajel Maximum Strength Toothache, RP Scherer Paracetamol, Terry White Chemists Paracetamol, Pharmacist Advice Paracetamol, Terry White Chemists Paracetamol Colourfree Children 5-12 Years, Paracare, Tylenol Childrens Paracetamol, Conney Aspirin-Free, Priceline Paracetamol, Panadol Gel Caps, Pacimol Caplets, Pharmore Paracetamol, Tylophen, Basics Paracetamol, Genapap, Sigma Pain Relief, Pain Clear Paracetamol, Paraspen Drops, Panadol Colourfree Drops, Pharmacist Paracetamol Infant Drops, Pharmacist Paracetamol Infant Drops Colour Free, Bi-Lo Paracetamol, Pain-Eze Paracetamol Infant Drops Colour Free, Pharmaction Paracetamol, Biochemie Paracetamol, Healthsense Pain Relief Drops Children 1 Month to 2 Years, Black And Gold Paraceatmol, Pharmacist Advice Paracetamol Infant Drops, Black and Gold Paracetamol, Hexal Comfarol, Abenol, Paracetamol Soluble, Vitapap, Bristol Pharma Paracetamol, Sigma Paracetamol, Actimol Infant, ConRx Extra Strength, PediaCare Infants' Acetaminophen Fever Reducer/Pain Reliever, PediaCare Children's Acetaminophen Fever Reducer/Pain Reliever, Pharmacy Health Paracetamol Colour Free Childrens, PediaCare Smooth Melts Acetaminophen Fever Reducer/Pain Reliever, Pharmacy Health Paracetamol Colour Free Infants and Childrens Drops 1 Month-4 Years, Mapap Children's, Capital Chemist Paracetamol, Lemsip Cold and Flu Liquid Capsule, Children's Silapap, Febrol Solution, Pharmacy Health Own Name Paracetamol for Children, Febridol Infant Drops, Accidental Rapatabs, Chem Mart Chemadol Children 1 to 5 Years, Chem Mart Chemadol Colourfree, Chem Mart Chemadol Colourfree Children 5-12 Years, Chemists Own Chiildrens Paracetamol 5-12 Years, Lemsip Headcold, Chemists Own Childrens Paracetamol 1-5 Years, Chemists Own Paracetamol, Lemsip Original, Chemists Own Paracetamol Capseals, Chemists Own Paracetamol Pain & Fever 1 Month to 2 Years, Chemists Own Paracetamol Pain & Fever 1 to 5 Years, Chemists Own Paracetamol Pain and Fever 5 to 12 Years, A-Pak Laboratories Paediatric Analgesic Paracetamol, Chemplus Paracetamol, Chemworld Colourfree Childrens Paracetamol Double Strength 5-12 Years, Chemworld Colourfree Childrens Paracetamol Junior 1-5 Years, Chemworld Paracetamol, Chemworld Paracetamol Infant Colour Free, HyVee Health 8 Hour Pain Relief, Bydol, Chem Mart Chemadol, Leader 8 Hour Pain Reliever, Children's ElixSure, Little Fevers, Mapap Rapid Release Gelcaps, Benylin Sore Throat, Fawns & McAllan Paracetamol, Zee Unaspirin ES, Chem Mart Chemadol Colourfree Childrens 1-5 Years, Midol Long Lasting Relief, Childrens Panadol 1 - 5 Years Colourfree, Childrens Panadol 1 - 5 Years, Childrens Panadol 5 - 12 Years Colourfree, Childrens Panadol 5 - 12 Years, Equaline Pain Relief, Help I Have A Headache, Febridol Clear Effervescent, Herron Paracetamol Tabsules, Panadol Rapid Handipak, Panadol Soluble, Paralgin Paracetamol Tabsules, Pharmacist Childrens Paracetamol Colourfree 1-5 Years, Pharmacist Childrens Paracetamol Colourfree 5-12 Years, Pharmacy Health Colour Free Childrens Paracetamol, Gold Cross Paracetamol, Tylenol Cold Sore Throat, Alpha First Aid Supplies Paracetamol, Guardian Childrens Paracetamol 5-12 Years, Guardian Paracetamol, Guardian Paracetamol Tabsules, Rex Paracetamol, Topcare Arthritis Pain Relief, Accidental First Aid Supplies Paracetamol, Panadol Jr, Flu Strength Hot Lemon Powders, Paineze Paracetamol, Health Care Chemist Paracetamol Infant Drops Colour Free, Genebs, Herron Gold Paracetamol Tabsules, Tylenol Regular Strength, Panamol, Herron Paracetamol, Tempra 2, Tempol, Herron Paracetamol Capseals, Tempra 3, Taminol, Herron Paracetamol Capseals Handy Pack, Herron Paracetamol Handy Pack, Apra, Q-Nol, Claradol, Anacin Aspirin Free, Conacetol, Coles Paracetamol, Genapap Extra Strength, Doliprane Sans Sucre, Dolitabs, Home Brand Paracetamol, Q-Pap Extra Strength, Dolko, ICN Paracetamol, Redutemp, Dolko Enfants, Dolotec, Vicks Formula 44 Custom Care Body Aches, James Dean Pharmacy Paracetamol, Pain-Eze, Uniserts, Efferalganodis, Silapap Childrens, Expandox, Dolono Infant, Geluprane, Paracetamol Arrow, Paracetamol Biogaran, Ed-APAP, Paracetamol EG, St. Joseph Aspirin-Free, Country Chemists Paracetamol, Paracetamol Merck, Liquiprin, Paracetamol Qualimed, Adprin B, Paracetamol RPG, DG Health Pain Reliever, Tempra Quicklets, Paracetamol Sandoz, Lloydspharmacy Paracetamol Six Plus, Paracetamol Winthrop, Triaminic Fever Reducer Pain Reliever, Lloydspharmacy Paracetamol Infant, Paracetamol Zydus, Atasol Forte, Paralyoc, Tylenol Cool Caplet Extra Strength, Perfalgan Nourrissons Et Enfants, Acetaminophen-odan, Mapap Rapid Tabs, Jr. Tylenol, Elixsure Fever/Pain, Infadrops, Disprol Paracetamol, Galpamol, Paldesic, Medinol Paediatric, Medinol Under 6, Infantaire Drops, Lemsip Pharmacy Non-Decongestant Formula, Calpol Six Plus, Masophen, Medinol Over 6, Nortemp Children's, Paracets, UN-Aspirin Extra Strength, Mandanol, Actimol Children's, Dakota Paracetamol, Miradol, Umphamol, Remedol, Panamax 240, Paralgin, Parahexal, Febridol, Mid West Products Numol Paracetamol, Silapap Infants, Cuprofen for Children, Mapap Infant Drops, Mandanol Infant, Cetafen Extra, Mandanol 6+, Lemsip Childrens Cold & Flu, Fennings Childrens Cooling, Duatrol SR, Aldi Hedanol Paracetamol, Under Ten Care Infant, Alphapharm Paracetamol, Amadol Paracetamol, No Frills Paracetamol, Tylenol Sore Throat Daytime, Nova Paracetamol, Mapap Meltaway, Numark Paracetamol, Amcal Childrens Paracetamol 1-5 Years, Nyal Paracetamol, Medi-Tabs, Amcal Childrens Paracetamol 5-12 Years, Amcal Paracetamol Pain Relief, Ordov Febrigesic Paracetamol, Topcare 8 Hour Pain Relief, Amcal Paracetamol Infant Drops 1 Month to 2 Years, Pain-Eze Paracetamol Infant Drops, Febridol Syrup for Children, Amcal Paracetamol Tabsules, Pharmacist Advice Colourfree Childrens Paracetamol Double Strength, Guardian Childrens Paracetamol, Pharmacist Formula Paracetamol, Pharmacist Formula Infants, Paraspen, RP Scherer Paracetamol Liquid-Filled Capsules, Savings Paracetamol, Signature Range Paracetamol, Dymadon, Soul Pattinson Childrens Paracetamol Elixir, Soul Pattinson Colour Free Paracetamol 1-5 Years, Soul Pattinson Colour Free Paracetamol Drops, Soul Pattinson Colourfree Childrens Paracetamol, API Healthcare Coloufree Childrens Paracetamol, Soul Pattinson Paracetamol, API Healthcare Colourfree Childrens Paracetamol Double Strength, Soul Pattinson Paracetamol Clear Effervescent, Panadol Mini Caps, API Healthcare Paracetamol, Pharmacy Health Paracetamol, Terry White Chemists Colour Free Paracetamol 1-5 Years, Pharmacist Paracetamol, Terry White Chemists Colour Free Paracetamol Infant Drops)
  • Adderall (amphetamine / dextroamphetamine)
  • Alcohol (contained in alcoholic beverages) (ethanol)
  • Aspirin Low Strength (aspirin)
  • azithromycin (Zithromax, Azithromycin Dose Pack, Z-Pak, Zmax)
  • Benadryl (diphenhydramine)
  • benzonatate (Tessalon Perles, Tessalon, Zonatuss)
  • Claritin (loratadine)
  • codeine
  • Cymbalta (duloxetine)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Sleep, Unisom SleepGels, Benadryl Children's Allergy, Sominex, Dicopanol, Diphen, Sleep Tabs, Simply Sleep, Diphedryl, Diphenadryl, Quenalin, Diphenyl, Hydramine, Diphenydramine Quick Melt, Unisom SleepMelts, Nytol, Dormin, Sleepwell 2-nite, Diphenhist, 40 Winks, Diphen Cough, DPH, Calm-Aid, Sleep Tab II, Altaryl, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Buckley's Bedtime, Hyrexin, Hydramine Cough Syrup, Bydramine, Diphen AF, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Genahist, Alka-Seltzer Plus Allergy, Q-Dryl, Aller-G-Time, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Diphendryl, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Q-Dryl A/F, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Pharbedryl, Histaprin, Z-Sleep, Tranquil Nighttime Sleep Aid, PediaCare Children's Allergy, Truxadryl, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flonase (fluticasone nasal)
  • guaifenesin (Mucinex, Robafen, Robitussin Chest Congestion, Tussin, Humibid, Tussin Expectorant, Guiatuss, Sorbutuss, Mucinex Maximum Strength, Guaiatussin, Mucus Relief, Diabetic Tussin Mucus Relief, Altarussin, Q-Tussin, Siltussin, Balminil Expectorant, Dristan Chesty Cough Guaiphenesin, Ganidin NR, Fenesin, Scot-Tussin Expectorant, Guaifenesin LA, Humavent LA, Lotussin, Robitussin Mucus + Chest Congestion, Guaifenex G, Benylin E, Mucinex for Kids, Buckley's Chest Congestion, Refenesen Chest Congestion Relief, Organidin NR, Benadryl Chesty Forte, G Bid, Touro EX, Pneumomist, Iofen-NF, Humibid Pediatric, Organ-1 NR, Iodrol NR, Mucinex Children's Chest Congestion, Guaibid-LA, Aquamist, Q-Bid LA, Amibid LA, Mucobid-LA, Guaifenex LA, Fenex-LA, Muco-Fen LA, Liquibid, Muco-Fen 800, Breonesin, Guiacough, GG 200 NR, Glytuss, Anti-Tuss, Diabetic Expectorant, Allfen Jr, Genatuss, Halotussin, Mastussin, Mytussin, Ri-Tussin, Robichem, Siltuss DAS, T-Tussin, Tusscidin, Gua-SR, Humigen LA, Sinumist, Altorant, Duratuss G, Diabetic Tuss, Naldecon-EX Senior, Phanasin, Iophen NR, GG-Cen, Muco-Fen 1200, Liquidbid LA, Liquidbid 1200, Calmylin Expectorant, Guiadrine G-1200, Siltussin DAS-NA, Iofen, Muco-Fen, Drituss G, Beechams Veno's for Kids Chesty Cough, Junior Meltus Colour and Sugar Free Expectorant, Help I Have Chest Congestion, Tixylix Chesty Cough, Xpect, Bidex-400, Humibid E, Fenesin IR, Hill's Balsam Chesty Cough, Jackson's Extra Strength All Fours, Junior Meltus Chesty Coughs with Catarrh, Liqufruta Garlic Cough Medicine, Family Meltus Chesty Coughs, Jackson's The Original All Fours, Beechams Veno's Expectorant, Lemsip Cough Chesty, Respa-GF, Nirolex Chesty Cough, Dristan Chesty Cough, Nyal Chesty Cough, Strepsils Chesty Cough, Kenkay Chesty Cough Eexpectorant, Pharmacist Expectorant, Guaifen NR, Liquituss GG, Lloydspharmacy Expectorant Adult Cough, Lloydspharmacy Expectorant Junior Cough, TabTussin 400, Siltussin DAS, Bronchoril, Hytuss, Actifed CC Chesty Cough, Mucaplex, Tussin Mucus + Chest Congestion, Air Power)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Children's Motrin, Proprinal, Motrin IB, Childrens Ibuprofen Berry, Advil Children's, Ibuprofen PMR, Ibu-8, Rufen, IBU-200, Motrin Childrens, Advil Migraine, Caldolor, Ibu-Tab, Menadol, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Pediatric, Genpril, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Motrin Junior Strength, Motrin Infant Drops, NeoProfen, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • Lexapro (escitalopram)
  • loratadine (Claritin, Alavert, Claritin 24 Hour Allergy, Loratadine Reditab, Allergy Relief 24 Hour, Claritin Reditabs, Allergy Relief Tablets, Wal-itin, Children's Claritin Allergy, Children's Allergy Relief 24 Hour, Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief, Help I Have Allergies, ohm Allergy Relief, Clear-Atadine, Claritin Hives Relief, Dimetapp Children's ND Non-Drowsy Allergy, Clear-Atadine Children's, Bactimicina Allergy, Tavist ND)
  • Lyrica (pregabalin)
  • Mucinex (guaifenesin)
  • Neosporin (bacitracin / neomycin / polymyxin b topical)
  • Norco (acetaminophen / hydrocodone)
  • Paracetamol (acetaminophen)
  • phenylephrine (Neo-Synephrine, Sudafed PE Congestion, Suphedrine PE, Nasal Decongestant PE, Help I Have A Stuffy Nose, Sudogest PE, Dimetapp Toddler's Drops Decongestant, Vazculep, Sudafed PE Children's Nasal Decongestant, Despec-SF, Nasop12, Triaminic Thin Strips Cold with Stuffy Nose, Phenyl-T, Congest Aid II, AH-Chew D, Gilchew IR, Little Colds Decongestant, Lusonal, Contac-D, Nasop, Ricobid-D, PediaCare Children's Decongestant)
  • pseudoephedrine (Sudafed Congestion, Sudafed 12-Hour, SudoGest, Entex, Sudafed 24-Hour, Silfedrine, Sudafed Children's Nasal Decongestant, Contac Cold, Suphedrin, Chlor-Trimeton Nasal Decongestant, Nexafed Nasal Decongestant, nasofed, Suphedrine, ElixSure Congestion, Children's Dimetapp Decongestant Infant, Allermed, Novafed, Cenafed, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Afrinol, Zephrex-D, Decofed Liquid, Efidac, Decofed, Kid Kare Drops, Myfedrine, Sudodrin, Elixsure Decongestant, Unifed, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant)
  • quinidine (Quinora, Quinidex Extentabs, Cardioquin, Quinaglute Dura-Tabs, Quin-Release, Quin-G)
  • Singulair (montelukast)
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zoloft (sertraline)
  • Zyrtec (cetirizine)

Dextromethorphan alcohol/food interactions

There is 1 alcohol/food interaction with dextromethorphan

Dextromethorphan disease interactions

There is 1 disease interaction with dextromethorphan:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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