Actemra Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Actemra (tocilizumab)	Humira (adalimumab)	Methotrexate	Enter another drug to compare

Actemra (tocilizumab)

Humira (adalimumab)

Methotrexate

Prescription only

Prescribed for Giant Cell Arteritis, Rheumatoid Arthritis, COVID-19, Cytokine Release Syndrome, Juvenile Idiopathic Arthritis, Polyarticular Juvenile Idiopathic Arthritis, Systemic... View more

Prescription only

Humira is a TNF-alfa inhibitor that may be used to treat a wide range of different inflammatory conditions, such as Rheumatoid Arthritis, psoriasis, ankylosing spondylitis, Crohn's disease, and... View more

Prescription only

Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more

More about Actemra (tocilizumab)

More about Humira (adalimumab)

More about Methotrexate

Ratings & Reviews

Actemra has an average rating of 6.7 out of 10 from a total of 49 ratings on Drugs.com. 57% of reviewers reported a positive effect, while 24% reported a negative effect.

Humira has an average rating of 6.4 out of 10 from a total of 702 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 30% reported a negative effect.

Methotrexate has an average rating of 6.5 out of 10 from a total of 338 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 24% reported a negative effect.

View all 49 reviews

View all 702 reviews

View all 338 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Actemra side effects

Pain (10.7%)
Headaches (4.7%)
Fatigue (4.4%)
Psoriasis (4.4%)
Rash (4.3%)
Tiredness (3.6%)
Itching (3.3%)

View all Humira side effects

Nausea (14.8%)
Tiredness (13.9%)
Fatigue (11.5%)
Hair loss (8.6%)
Pain (6.8%)
Headaches (5.6%)
Loss of appetite (5.0%)

View all Methotrexate side effects

Drug Class

Interleukin inhibitors

Generic Availability

N/A

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	4 mL
Strength	20 mg/mL
Per unit^*	$144.26
Cost^*	$577.02

View all Actemra prices

Quantity	2 kit
Strength	40 mg/0.8 mL
Per unit^*	$3,700.02
Cost^*	$7,400.03

View all Humira prices

Quantity	20 each
Strength	2.5 mg
Per unit^*	$1.52
Cost^*	$30.31

View all Methotrexate prices

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Dosage Forms

Intravenous solution
Subcutaneous solution

Subcutaneous kit

Injectable powder for injection
Injectable solution
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

210 hours

480 hours

15 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Drug Interactions

A total of 430 drugs are known to interact with Actemra:

59 major drug interactions (166 brand and generic names)
363 moderate drug interactions (1233 brand and generic names)
8 minor drug interactions (36 brand and generic names)

A total of 553 drugs are known to interact with Humira:

300 major drug interactions (870 brand and generic names)
244 moderate drug interactions (942 brand and generic names)
9 minor drug interactions (37 brand and generic names)

A total of 726 drugs are known to interact with Methotrexate:

145 major drug interactions (669 brand and generic names)
566 moderate drug interactions (2742 brand and generic names)
15 minor drug interactions (47 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are... View more
Methotrexate may cause liver problems, and using it with other medications that can also affect the... View more

Disease Interactions

First Approval Date

January 08, 2010

December 31, 2002

December 07, 1953

WADA Class View classifications

N/A

More Information

Patient Resources

Actemra uses

Humira uses

Methotrexate uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Actemra Alternatives Compared

See also:

Humira

Rinvoq

Entyvio

Deltasone

Rayos

Tyenne

Sterapred

Tofidence

Upadacitinib

Prednisone

Further information

Actemra Alternatives Compared

See also:

Further information

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