Actemra Alternatives Compared
| Actemra | Humira | Methotrexate |
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| Actemra (tocilizumab) | Humira (adalimumab) | Methotrexate |
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Prescription only
Prescribed for Giant Cell Arteritis, Rheumatoid Arthritis, COVID-19, Cytokine Release Syndrome, Systemic Sclerosis-Associated Interstitial Lung Disease, Juvenile Idiopathic Arthritis. Actemra may... View more |
Prescription only
Humira is a TNF-alfa inhibitor that may be used to treat a wide range of different inflammatory conditions, such as Rheumatoid Arthritis, psoriasis, ankylosing spondylitis, Crohn's disease, and... View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Related suggestions Rheumatoid Arthritis
Juvenile Idiopathic Arthritis
Popular comparisons
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| More about Actemra (tocilizumab) | More about Humira (adalimumab) | More about Methotrexate | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Actemra has an average rating of 6.9 out of 10 from a total of 39 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 19% reported a negative effect. |
Humira has an average rating of 6.3 out of 10 from a total of 643 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 32% reported a negative effect. |
Methotrexate has an average rating of 6.5 out of 10 from a total of 268 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 24% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See also: Actemra side effects in more detail. |
Common side effects include:
See also: Humira side effects in more detail. |
Commonly reported side effects include:
See also: methotrexate side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Actemra prices |
View all Humira prices and generic prices |
View all methotrexate prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
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N/A |
Other adalimumab brands include: Abrilada, Amjevita, Cyltezo, Hadlima, Hulio, Hyrimoz, Yusimry | Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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210 hours |
480 hours |
15 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 295 drugs are known to interact with Actemra:
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A total of 426 drugs are known to interact with Humira:
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A total of 631 drugs are known to interact with methotrexate:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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January 08, 2010 |
December 31, 2002 |
December 07, 1953 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.