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Zometa and Pain: What Users Say

Pain: mentioned by 10 users (22.7%)

Based on user experiences from 44 Zometa reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

chills 22.7%
pain 22.7%
fever 15.9%
flu-like symptoms 13.6%
joint pain 13.6%
body aches 11.4%
bone pain 11.4%
headaches 11.4%
tiredness 11.4%
back pain 9.1%

Reviews for Zometa

Commonly mentioned side effects
  • Blu...
  • Taken for 1 to 6 months
  • February 28, 2020

For Hypercalcemia of Malignancy "My oncologist ordered this as a bone treatment. I was doing just fine without it. Now my legs are in pain, and I'm tired most of the time. I will NEVER take this crap again. It's a typical poison that America's corrupt pharmaceutical industry pushes on people. There are other, safer ways to get your damaged bones to absorb calcium. I have nothing but the most profound contempt for the makers of this product."

1 / 10
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72 Report
  • Jac...
  • Taken for less than 1 month
  • June 16, 2017

For Osteolytic Bone Metastases of Solid Tumors "Had my first dose on Monday, 12th June 2017. I was fine Monday night, so I felt quite positive. Woke up Tuesday feeling like death! Wednesday, I felt better but had a painful, red, swollen left eyeball. Long story short, I'm in agony with my eye, and no one knows what to do! The hospital tried to say it wasn't a side effect! It's a very rare side effect, but it is one! And the fact they know nothing about it or how to deal with it is disgusting and frightening! I will not be having this treatment again and will be taking this further! They should not be giving people something if they don't know everything about it!"

2 / 10
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71 Report
  • Jan...
  • December 11, 2016

For Osteoporosis "Had the infusion - 15 minutes - 4 days ago. On the day, felt fine. The next day, thought I was dying, chills, fever, nausea, whole body/bones/joints extremely painful. Woke up every hour and had to drink water. Day 3, felt a lot better and managed to go to work. Day 4, I feel fine. Not sure how effective it will be, will have to have a bone scan in a year's time!"

8 / 10
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50 Report

Frequently asked questions

  • Mae...
  • Taken for 5 to 10 years
  • November 29, 2020

For Osteoporosis "The Zometa was almost the end of me. I was 70 years old when doctors in Sardinia gave me the Zometa for only a broken rib. They gave it to me for 1 year. Meanwhile, my bones were becoming weaker and weaker every day. My jaw became painful and was almost impossible to talk, eat, and chew. My bones started to have fractures without any particular accident. Doctors gave me Zometa for 6 years. After 1 year, the Zometa caused me bone cancer. If Zometa is good for bones, then why after 1 year of infusions I've had bone cancer?"

1 / 10
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32 Report
  • Deb...
  • September 3, 2017

For Osteoporosis "Had 1 T-7 fracture due to the osteoporosis. Recently had the Reclast infusion, and it is awful. Flu-like symptoms? No way, much, much worse. I literally was incapacitated. The pain everywhere in my bones, joints, hips, even my fingers. I feel my doctors were not honest with me about how I would or could really feel. On the positive though, I hope in one year my bone density and bone mass will have improved. I don't want another fracture."

3 / 10
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41 Report

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  • lis...
  • December 12, 2013

For Osteolytic Bone Metastases of Solid Tumors "I have had three infusions (1 monthly) intravenously administered. No one advised that I should continue taking calcium supplements - good thing I asked! The first infusion led to three days of severe joint pain abating each day. The second infusion had lesser effects, and the third one lessened from the 2nd. Hydrate well before and after the injections. I've had transient chest pain, chills, side pain, episodes lasting for 1-2 minutes."

7 / 10
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49 Report
  • Jim...
  • Taken for less than 1 month
  • September 13, 2016

For Osteolytic Bone Lesions of Multiple Myeloma "This new 20 min IV just about killed me and put me in the hospital for 7 days, then rehab for 2 weeks. I had chronic upper thigh pain which made my right leg and foot numb, and I need a walker to walk now. My calves also are very painful. This IV stopped my urination, and I had to go to the ER. My urethra tube was completely closed, and the urologist got 3 1/2 liters off my bladder. I have to now have a catheter for the rest of my life. My kidneys did turn around but were very bad in the hospital. I have stage 4 prostate cancer and was on Adriamycin and Lupron shot every 3 months. The Adriamycin IV was 2 hrs. I handled these meds very well, but my new oncologists decided to change to Zometa. I was not told about all of these side effects."

1 / 10
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29 Report
  • Cat...
  • Taken for 1 to 2 years
  • March 15, 2019

For Osteolytic Bone Metastases of Solid Tumors "I took Zometa for two years until I noticed a hole in my mouth where my jawbone was poking through. Now it’s been a year, and the hole has tripled in size and is starting to get more painful. This drug is horrible."

3 / 10
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15 Report
  • Sed...
  • Taken for 1 to 6 months
  • July 17, 2021

For Osteolytic Bone Lesions of Multiple Myeloma "I was placed on Zometa by my oncologist as a preventive medication to avoid bone lesions and fractures. I was diagnosed with multiple myeloma earlier in the year. I fortunately do not have bone issues at this point, however, my doctor thought it might help with prevention. After my first infusion, I developed severe chills, fever, and terrible calf pain 24 hours later. The fever, chills, and pain fortunately disappeared about a day or two later, but the fatigue lasted for days. Before my second monthly infusion, I drank more water. This did seem to help with avoiding chills and fever, but 24 hours later, I again developed bad calf pain and realized I had edema in my legs. A day later, it is better, but again, I have horrible fatigue and bloating. The side effects of this medicine are worse than those of my cancer meds. I will have to talk to my doctor, as I am not willing to do this every month unless I really have to."

2 / 10
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6 Report
  • TKB...
  • October 18, 2016

For Osteolytic Bone Metastases of Solid Tumors "I have been taking Zometa for breast cancer with metastasis to the bones and have been on it for 8 months now, and I have only had minor aches and pains... no major complications from the drug."

10 / 10
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22 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.