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Zometa Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Zometa Denosumab Alendronate
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Zometa (zoledronic acid) Denosumab Alendronate
Prescription only

Zometa is only available as an injection for administration by a healthcare provider and is indicated for the treatment of hypercalcemia associated with cancer, osteolytic bone lesions of multiple... View more

Prescription only

Denosumab is an injection that can be self-administered once every six months for the treatment of osteoporosis. It has been associated with an increased risk of fractures on discontinuation... View more

Prescription only

Alendronate helps to reduce the risk of fracture in people with osteoporosis and some other bone conditions. Dosage instructions, including remaining upright for at least 30 minutes and taking with a... View more

More about Zometa (zoledronic acid) More about Denosumab More about Alendronate
Generic Status

Lower-cost generic is available

No lower-cost generic available

Lower-cost generic is available
Ratings & Reviews

Zometa has an average rating of 4.5 out of 10 from a total of 39 ratings on Drugs.com. 31% of reviewers reported a positive effect, while 53% reported a negative effect.

Denosumab has an average rating of 2.8 out of 10 from a total of 345 ratings on Drugs.com. 15% of reviewers reported a positive effect, while 77% reported a negative effect.

Alendronate has an average rating of 2.2 out of 10 from a total of 149 ratings on Drugs.com. 12% of reviewers reported a positive effect, while 85% reported a negative effect.

View all 39 reviews

View all 345 reviews

View all 149 reviews

Drug Class
Side Effects

Common side effects include:

  • hypophosphatemia
  • hypokalemia
  • hypomagnesemia

See also: Zometa side effects in more detail.

Commonly reported side effects include:

  • dermatitis
  • eczema
  • skin rash

See also: denosumab side effects in more detail.

Commonly reported side effects include:

  • decreased serum calcium
  • decreased serum phosphate

See also: alendronate side effects in more detail.
Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.

We could not find an exact match for this medicine. Try searching the Price Guide directly.
Quantity 4 tablet
Dosage 70 mg
Per Unit* $4.51 - $7.72
Cost* $18.03 - $30.89

View all alendronate prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Form(s) Available
  • Intravenous solution

N/A
  • Oral solution
  • Oral tablet
Brand Names
Other zoledronic acid brands include: Aclasta, Reclast Prolia, Xgeva Binosto, Fosamax
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

N/A

609.6 hours

N/A
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
X
Category X Not for use in pregnancy

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 114 drugs are known to interact with Zometa:

  • 26 major drug interactions (152 brand and generic names)
  • 88 moderate drug interactions (403 brand and generic names)

A total of 250 drugs are known to interact with denosumab:

  • 2 major drug interactions (5 brand and generic names)
  • 248 moderate drug interactions (728 brand and generic names)

A total of 106 drugs are known to interact with alendronate:

  • 2 major drug interactions (6 brand and generic names)
  • 99 moderate drug interactions (1759 brand and generic names)
  • 5 minor drug interactions (45 brand and generic names)
Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • Food may reduce the absorption of alendronate, which may lead to lower blood levels of the... View more
Disease Interactions
First Approval Date

February 22, 2002

N/A

September 29, 1995
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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