Zometa Alternatives Compared
| Zometa (zoledronic acid) | Xgeva (denosumab) | Denosumab |
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| Zometa (zoledronic acid) | Xgeva (denosumab) | Denosumab |
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Prescription only
Zometa is only available as an injection for administration by a healthcare provider and is indicated for the treatment of hypercalcemia associated with cancer, osteolytic bone lesions of multiple... View more |
Prescription only
Xgeva is an injection that is administered every four weeks to prevent bone fractures in people with certain types of cancer or to lower calcium levels in people with high calcium levels caused by... View more |
Prescription only
Denosumab is an injection that can be self-administered once every six months for the treatment of osteoporosis. It has been associated with an increased risk of fractures on discontinuation... View more |
Related suggestions Osteolytic Bone Metastases of Solid Tumors
Hypercalcemia of Malignancy
Osteolytic Bone Lesions of Multiple Myeloma
Popular comparisons
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| More about Zometa (zoledronic acid) | More about Xgeva (denosumab) | More about Denosumab | ||||||||
| Ratings & Reviews | ||||||||||
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Zometa has an average rating of 4.8 out of 10 from a total of 44 ratings on Drugs.com. 32% of reviewers reported a positive effect, while 50% reported a negative effect. |
Xgeva has an average rating of 6.1 out of 10 from a total of 9 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 33% reported a negative effect. |
Denosumab has an average rating of 3.0 out of 10 from a total of 397 ratings on Drugs.com. 17% of reviewers reported a positive effect, while 74% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||
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View all Zometa side effects |
View all Xgeva side effects |
View all Denosumab side effects |
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| Drug Class | ||||||||||
| Generic Availability | ||||||||||
| Lower cost generic approved |
N/A |
N/A |
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| Pricing and Coupons * Prices are without insurance | ||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Xgeva prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Forms | ||||||||||
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N/A |
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| Brand Names | ||||||||||
| Other zoledronic acid brands include: Aclasta, Reclast | Other denosumab brands include: Bomyntra, Conexxence, Jubbonti, Osenvelt, Ospomyv, Prolia, Stoboclo, Wyost, Xbryk View more | Bomyntra, Conexxence, Jubbonti, Osenvelt, Ospomyv, Prolia, Stoboclo, Wyost, Xbryk, Xgeva View more | ||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||
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N/A |
609.6 hours |
609.6 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||
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Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||
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A total of 123 drugs are known to interact with Zometa:
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A total of 308 drugs are known to interact with Xgeva:
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A total of 308 drugs are known to interact with Denosumab:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||
| First Approval Date | ||||||||||
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February 22, 2002 |
June 01, 2010 |
N/A |
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| WADA Class View classifications | ||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||
| Patient Resources | ||||||||||
| Professional Resources | ||||||||||
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N/A |
N/A |
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| Related Treatment Guide | ||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Prolia
Prolia (denosumab) is an injection that is administered subcutaneously (under the skin) once every ...
Fosamax
Fosamax (alendronate) is used to treat or prevent postmenopausal osteoporosis and steroid-induced ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Premarin
Premarin is used to treat symptoms of menopause such as hot flashes, and vaginal dryness. Learn ...
Reclast
Reclast (zoledronic acid) is used to treat osteoporosis in women after menopause and also to treat ...
Tymlos
Tymlos (abaloparatide) is used to treat osteoporosis in men and postmenopausal women who have a ...
Calcium/vitamin d
Calcium/vitamin d is used for dietary supplementation, osteoporosis
Ibandronate
Ibandronate is used for osteoporosis, prevention of osteoporosis
Raloxifene
Raloxifene is used for breast cancer, prevention, osteoporosis, prevention of osteoporosis
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.