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Xgeva Disease Interactions

There are 2 disease interactions with Xgeva (denosumab).


Denosumab (applies to Xgeva) hypocalcemia

Major Potential Hazard, Moderate plausibility. Applicable conditions: Hypoparathyroidism, Thyroid Disease, Renal Dysfunction

Preexisting hypocalcemia must be corrected prior to initiating treatment with denosumab. Caution should be exercised in patients predisposed to hypocalcemia and any disturbances of mineral metabolism, such as history of hypoparathyroidism, thyroid or parathyroid surgery, malabsorption syndromes, excision of small intestine, severe renal impairment or dialysis. Clinical monitoring of calcium and mineral levels (phosphorus and magnesium) are highly recommended within 14 days of denosumab injection. It is important to maintain calcium levels with adequate calcium and vitamin D supplementation.


  1. "Product Information. Prolia (denosumab)." Amgen USA (2010):

Denosumab (applies to Xgeva) immunosuppression

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Immunodeficiency

Denosumab should be used with caution in patients with impaired immune systems or taking concomitant immunosuppressant agents as they may be at increased risk for serious infections.


  1. "Product Information. Prolia (denosumab)." Amgen USA (2010):

Xgeva drug interactions

There are 271 drug interactions with Xgeva (denosumab).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.