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Xgeva Approval History

Xgeva (denosumab) is a RANK ligand (RANKL) inhibitor indicated for the prevention of skeletal-related events in patients with bone metastases from solid tumors, and for the treatment of giant cell tumor of the bone.

Development History and FDA Approval Process for Xgeva

DateArticle
Dec  8, 2014Approval FDA Approves Xgeva (denosumab) for Hypercalcemia of Malignancy Refractory to Bisphosphonate Therapy
Jun 13, 2013Approval FDA Approves Xgeva to Treat Giant Cell Tumor of the Bone
Nov 19, 2010Approval FDA Approves Amgen's Xgeva (denosumab) for the Prevention of Skeletal-Related Events in Patients with Bone Metastases from Solid Tumors

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