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Zometa and Headaches: What Users Say

Headaches: mentioned by 6 users (13.3%)

Based on user experiences from 45 Zometa reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

chills 24.4%
pain 22.2%
fever 15.6%
body aches 13.3%
flu-like symptoms 13.3%
headaches 13.3%
joint pain 13.3%
bone pain 11.1%
tiredness 11.1%
back pain 8.9%

Reviews for Zometa

Commonly mentioned side effects
  • jak...
  • Taken for less than 1 month
  • June 6, 2019

For Osteoporosis "For four weeks, I had little to no appetite and periods of tiredness. For the first 3 weeks, I was also in a stupor, tired, and weak every day, with nausea daily. Along with these symptoms, for the first 2 weeks, I had on and off fever, chills, headache, no energy, sweats at night. I felt like I was drugged and was weak, unstable, and sick. I would never, never take Zometa again, and I do NOT recommend it."

2 / 10
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118 Report
  • Anonymous
  • Taken for 6 months to 1 year
  • October 29, 2021

For Osteoporosis "Worst medication I’ve ever had. I got all the severe side effects. Joint and muscle pain, headache, nausea, chest and abdominal pain, chills. This medication is torture. If you want to experience all kinds of body aches and pain, take this medication. I do not recommend it, and I will never take it anymore, even if I was going to die."

1 / 10
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47 Report
  • Blo...
  • May 22, 2020

For Osteoporosis "I will never try Zometa again. I had horrific side effects. I passed out 7 hours after home from infusion, my neighbor called paramedics. My blood pressure dropped to 80/58. I’ve had full body ache, headache, sweats, and chills for 3 days so far."

1 / 10
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54 Report

Frequently asked questions

  • Emm...
  • Taken for 1 to 6 months
  • July 23, 2025

"Had 2nd infusion on Monday to prevent bone cancer after breast cancer in '23 and strengthen bones. 1st infusion made me so ill I couldn’t get out of bed to get a bucket to vomit in because I was so weak and dizzy. I started to feel a bit human 5 days later. 2nd infusion has been worse: violent vomiting, chills, aches, headaches, and get this, panic attacks! Yes, I’ve researched it, it’s strongly linked to anxiety, and if you’re someone who’s ever suffered with anxiety or depression, it can cause panic episodes. I can’t stand this drug and am going to ask my oncologist tomorrow for an alternative. Chemo wasn’t this bad."

4 / 10
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1 Report
  • Vet...
  • June 25, 2016

For Osteolytic Bone Metastases of Solid Tumors "Severe head pain, loss of appetite, lower back and spinal pain."

5 / 10
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18 Report
  • rob...
  • Taken for less than 1 month
  • January 22, 2015

For Osteolytic Bone Metastases of Solid Tumors "IV Zometa yesterday. Woke up this morning, body aches, headache, fever, slept all day."

2 / 10
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18 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.