Semaglutide User Reviews & Ratings
Brand names: Ozempic, Wegovy, Rybelsus
Semaglutide has an average rating of 6.9 out of 10 from a total of 2,787 reviews on Drugs.com. 56% of reviewers reported a positive experience, while 20% reported a negative experience.
Condition | Avg. Rating | Reviews | Compare |
---|---|---|---|
Type 2 Diabetes | 1520 reviews for Type 2 Diabetes | 159 medications | |
Weight Loss (Obesity/Overweight) | 875 reviews for Weight Loss (Obesity/Overweight) | 60 medications | |
Cardiovascular Risk Reduction | 250 reviews for Cardiovascular Risk Reduction | 24 medications | |
Chronic Kidney Disease | 6 reviews for Chronic Kidney Disease | 9 medications |
Reviews for Semaglutide
- aun...
- Taken for 1 to 6 months
- September 6, 2025
Semaglutide for Chronic Kidney Disease "I use Ozempic for chronic kidney disease. I was in the beginning of stage 4 in the GFR stages, a 29. After 1 month of Ozempic, I'm now in stage 3a with a GFR of 45. This means I don't have to worry about dialysis for right now. I did have severe nausea, with some vomiting, and a slight headache in the beginning, but those have gone away. Now I concentrate on making sure I am drinking enough water, eating enough food, and getting the correct amount of protein for me. I have lost over 20 lbs in that month, which means almost 2 clothes sizes lost. The Ozempic is easy to use, just attach a new needle, dial in the dose, and inject into a fatty area once a week. It has done what I had hoped for, it stopped the progression of the CKD (chronic kidney disease) while also causing a much-needed weight loss. Due to other health issues, I am unable to exercise much, so the weight loss is because of the effects of the Ozempic. I have also gone from prediabetic to normal blood glucose level and A1C."
- Mir...
- Taken for 1 to 6 months
- August 26, 2025
Semaglutide "No side effects and slow weight loss. Very effective."
Frequently asked questions
- Ozempic Side Effects to Watch For
- Wegovy vs Ozempic: Which is Right for You?
- Which GLP-1 drug is best for weight loss?
- Tirzepatide vs semaglutide: How do they compare?
- P K...
- August 21, 2025
Semaglutide for Weight Loss (Obesity/Overweight) "My experience was exceptional. In 2 years on the medication, I lost 150 pounds and reached my goal weight. It took away almost all cravings and reduced my appetite. I feel and look great. I have a whole new outlook on life, and my self-confidence is back."
- mar...
- Taken for 5 to 10 years
- August 15, 2025
Semaglutide for Type 2 Diabetes "Has helped with blood sugar, keeps it low as long as I take metformin with it. It helps with type 2 diabetes."
- Ano...
- Taken for less than 1 month
- July 31, 2025
For Weight Loss (Obesity/Overweight) "Great experience. Little side effects. Using it along with a restricted high-protein diet and exercise. Have lost 5 lbs in a week. Current dosage 0.25."
- Ano...
- Taken for 1 to 6 months
- July 30, 2025
For Weight Loss (Obesity/Overweight) "I'm 6 weeks in on semaglutide compound. Started with the 0.25 dose, just went up. I have PCOS and have struggled since I was 18 (38 now). I hovered between 200 pounds all of my 20s and closer to 220 since COVID. I'm semi-active with an office job. I'm not a glutton by any means, but I love a weekend beer and dessert. This medicine was an immediate game changer! After the initial nausea and lack of appetite, it's been smooth sailing. I've lost 1.5-2 pounds a week. I think what really helps is learning what to eat. High protein and fiber are the majority of my diet now. I don't have cravings, I eat fewer portions, and bad foods I'd love before disgust me now. Down 15 pounds in 6 weeks. Over time, tweaking my fiber intake will help with constipation as that is definitely a side effect, but overall, I'm extremely happy! My insurance doesn't cover it, so I'm paying out of pocket."
More FAQ
- Can you get tirzepatide from a compounding pharmacy?
- Why am I not losing weight on Ozempic?
- Does Ozempic cause muscle loss and how to prevent it?
- How much does semaglutide cost?
- Mar...
- Taken for 1 to 2 years
- July 30, 2025
Semaglutide for Type 2 Diabetes "I have been taking this drug for over a year. I have encountered occasional constipation, so I would increase my fiber intake and this would easily be corrected. My blood sugar is doing well now. I also take 2 mg of glimepiride."
- jay...
- Taken for 6 months to 1 year
- July 30, 2025
Semaglutide for Type 2 Diabetes "I have been on Ozempic since 8/24. I have had no side effects at all. My A1C has come down significantly. I have lost 87 lbs and 6 pants sizes. I recommend Ozempic for all diabetics who also want to lose weight."
- Ano...
- Taken for less than 1 month
- July 12, 2025
For Weight Loss (Obesity/Overweight) "Starting week 3 with 3rd injection. Down 17 lbs, zero side effects. I inject in my thigh. Life is normal other than I just don't eat as much as before. This med is great for helping you know when you are full. Love it!!"
- Vis...
- Taken for less than 1 month
- July 9, 2025
Semaglutide for Weight Loss (Obesity/Overweight) "It’s my second week on 0.25 mg, I’ve lost 8.8 pounds in 8 days. Agree the first couple of days was water retention but I see it in my face and reduced belly fat. First day I had a headache but not really suffered any of the side effects as such. I have RA and in the first few days the swelling in my hands and knees has reduced significantly. I feel from an RA point of view the best I’ve felt in years in such a short time."
- Ano...
- Taken for 6 months to 1 year
- June 30, 2025
Semaglutide for Type 2 Diabetes "When diagnosed with type 2 diabetes, Ozempic was prescribed. I took it for 6 months and my general health improved significantly. My A1C went from 11 to 5.5. I also have borderline kidney disease and a heart condition, both of which were helped by the Ozempic. I am way overweight and I lost 27 lbs. Unfortunately, ResMed stopped covering it and the cost went up to over $2,000 per month, which I can't afford. With obesity being the chief cause of many illnesses, it would seem this should be near the top of conditions that need to be remedied."
- nab...
- Taken for 1 to 6 months
- June 27, 2025
Semaglutide for Weight Loss (Obesity/Overweight) "The medication was good for the first 2 months, but I'm stuck at my current weight for about 4 months. Just got an increase to 1.7 mg, so hopefully I will start losing more weight."
- Hum...
- Taken for 1 to 6 months
- June 26, 2025
For Weight Loss (Obesity/Overweight) "Weight loss is going good with a 20 lbs reduction in 10 weeks with the use of Semaglutide injections of 0.25 and 0.5 mg (Pakistan). The side effects that I have faced multiple times in these 2.5 months are diarrhea, bloating, gas, and burping."
- dre...
- Taken for 2 to 5 years
- June 25, 2025
Semaglutide for Type 2 Diabetes "This has kept my blood sugar regulated and has helped me get control of my weight."
- Ano...
- Taken for less than 1 month
- June 16, 2025
Semaglutide "I have completed my first 4 weeks with Rybelsus, dose 3 mg, -4 kg. I take the pill first thing in the morning between 5 and 6 a.m. Only on the weekend do I eat breakfast 1-2 hours after taking a pill, during the week, it's roughly 3 hours before I eat. I noticed mainly that I don't crave sweets that often anymore (still eat some sometimes, but really small portions). In general, small portions of food, which I am really happy about as I used to eat too big portions. In the first week, I had a headache, but I realized it was my fault, I felt full when drinking water, thus did not drink enough, but after a couple of days, that was better."
- Sal...
- Taken for 1 to 2 years
- June 14, 2025
Semaglutide for Weight Loss (Obesity/Overweight) "The nausea eventually stops. Take stool softeners for constipation and get ready to be thin again. I love it."
- Wan...
- Taken for 1 to 6 months
- June 10, 2025
Semaglutide for Weight Loss (Obesity/Overweight) "I've been taking Wegovy since September (2024). I initially did not like the way it made me feel. I was experiencing constipation, headaches, and nausea. My next dose was 0.50, which the pharmacy was out of until this past April 2025. I was determined to see if I could withstand the side effects. My appetite was suppressed immediately. I experienced constipation, which I counteracted with stool softeners every day. I took Zofran for the nausea. I had started riding my stationary bike around the same time that I started Wegovy. On April 17th, 2025, I started walking 30 minutes a day. I am now at a 1.7 dose. Side effects are minimal. I noticed that if I am constipated, I would get nauseous. Stay away from heavy grease. I consume a protein shake every morning and try to eat meat as much as I can as I do not really have a taste for meat or I no longer like alcohol. I am happy that I tried it again. I am 6'1" and was 283. I am 266. I want to be 240. Yay!"
- weg...
- Taken for 1 to 6 months
- June 10, 2025
Semaglutide for Weight Loss (Obesity/Overweight) "I'm so amazed with Wegovy. I lost 47 pounds in 5 months. No side effects. I was scared at first, but if you want to lose weight, try Wegovy. I started exercising, changed my diet, the weight started coming off the first week."
- Les...
- June 9, 2025
Semaglutide for Cardiovascular Risk Reduction "Starting my third week on Wegovy. 7.2 pounds gone. No side effects and feel great!"
- Ano...
- Taken for 2 to 5 years
- June 9, 2025
Semaglutide for Weight Loss (Obesity/Overweight) "This medicine is life-changing! I have never felt more healthy physically and mentally. Food no longer controls my life. I eat to fuel my body and want to choose healthier options. I don't waste the little I do eat on empty calories. I'm not beating myself up for not having any willpower or making bad choices, and I'm not ashamed of the way I look. My knees don't hurt and I haven't been sick (cold or flu) much, if at all. The injection is painless, easy to administer, and so quick. I have not experienced any side effects. I just feel normal for the first time ever and am so grateful for this breakthrough."
- Ano...
- Taken for 6 months to 1 year
- June 8, 2025
Semaglutide for Type 2 Diabetes "After taking Metformin and my doctor seeing it could cause kidney problems, he switched me to Pioglitazone. I asked if there was something that would help me lose weight (5'11", 270 lbs). He prescribed Ozempic 2.5 to handle both T2 diabetes and help with weight. It has aided in keeping my glucose down around the 100 mark, and I have lost down to 247, and that's in less than a year. I only eat when I am hungry, which is never, but eat for nutrition in smaller amounts. I am pleased so far with the product. I did find out through research that it slows the stomach emptying, which explains a pooched stomach for a few days until I can evacuate it. So eating less in quantity and more in quality helps with that."
- Ano...
- Taken for 1 to 6 months
- June 8, 2025
Semaglutide for Weight Loss (Obesity/Overweight) "My experience with Wegovy has been typical. I’ve experienced diarrhea and constipation, but all of it was manageable and comes and goes. I'm a believer. The medication is working for me. 45 lbs down in six months without working out due to a knee and back injury. I would 100% recommend it to anyone."
- Jan...
- Taken for 1 to 2 years
- June 5, 2025
Semaglutide for Type 2 Diabetes "Ozempic is working wonders for my type 2 diabetes. However, I have not lost one pound."
- ASi...
- Taken for 1 to 6 months
- June 1, 2025
Semaglutide for Type 2 Diabetes "I've been on Rybelsus tablets for 6 weeks now. I felt no difference on the 3 mg, but the 7 mg has given me headaches, bloating, diarrhea, and blurred vision sometimes. However, because it has brought my blood glucose from an average of 14 - 16 mmol in the morning to 9 mmol, the side effects are worth it. I've tried so many medications over the past 15 years, and only insulin and this Rybelsus have ever actually made any real difference. Since moving up to the 7 mg tablets, I have lost 5 pounds in a week, so all in all, this drug has been a Godsend to me. I only wish the tablets tasted better and were smaller to take. They taste vile to me, and I do struggle to swallow them because of their size and mostly because of their taste. So far, I am very pleased to finally have a drug that actually does seem to work. I am so grateful that I am in the UK and I get this medication for free."
See also:
More about semaglutide
- Check interactions
- Compare alternatives
- Latest FDA alerts (5)
- Side effects
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- Patient tips
- During pregnancy
- Support group
- Drug class: GLP-1 Agonists (Incretin Mimetics)
- Breastfeeding
Semaglutide for Weight Loss (Obesity/Overweight) "I am a pretty diabetic with IBS and sexual dysfunction. After I quit smoking, I gained a lot of weight. My doctor started me on 0.25 Wegovy, and I started to lose 5 lbs a week. My IBS symptoms improved. I was eating every two hours before, now I'm eating smaller portions and at regular intervals. After I got used to the dosage, the weight loss went down to a pound a week. The doctor bumped me up to 0.50, and I'm back in business. The sexual issues I was having have disappeared completely. Frequency, duration, and libido have all returned to what they were in my 20s. All of my side effects have been wonderful side effects. I have better mobility now that a lot of the weight has come off, more energy, and a much improved overall quality of life. The only negative thing I can think of isn't with the medication but the application. I have had two pens not inject the medicine into a very fatty area like the stomach. It seemed like the needle didn't reach, medication was left on top of my skin."