Naloxegol for Opioid-Induced Constipation User Reviews (Page 3)

• Mystro
• Taken for less than 1 month
• August 8, 2021

Movantik (naloxegol) "I took this medicine and I’m on 95Mg daily of methadone for the past 5 years. Within 20 min I had to poop and then I started feeling icky. I went into full blown withdrawal and it was terrible. I was shaking, freezing and sweating, nausea was intense, yawning, runny nose, back pain, and every 10 min I had more cramping and pooping until my bowel was completely empty. Finally I trued taking more methadone but it was being blocked out and wasn’t helping. I then took some Tylenol, and a few mg of Xanax and it put knocked me out and I feel asleep finally. Luckily when I woke up the withdrawal had passed but I was in withdrawal for around 3-6 hours. It’s midnight now and I’m extremely sore from back spasms and my stomach feels awful. Please don’t take this garbage. Pooping is not this important. Use a stool softener daily . This was the worst day of my life in 5 years."

• Thank...
• October 9, 2019

Movantik (naloxegol) "Was given a sample of 25mg from my doc, the pharmacy said not covered on my plan. Got a note months later from my provider that an appeal on my behalf has been ruled favorable on my side. Although still $100 co-pay, I thought I'd try it and if it works it'll be well worth the cost. I took a tablet from my sample. Within 20 mins cramps started (no sweat, that's expected), another 10 mins and strange sounds started rumbling deep in my gut and the surprisingly tranquil farting started. Another 15 mins and I was having a bowel movement and was overjoyed. After a few of these I got a sharp pain in my lower back, I started yawning, cold sweats and proceeded to have explosive diarrhea for the next 6 hours straight, I also had a severe migraine and thoughts of impending doom. It took 11 hours before my bowels calmed down, I actually slept in my recliner lined with plastic trash bags in case I blew containment. Now nearly 24 hours later, my gut is finally somewhat back to normal. $2.49 Enema."

• Subox...
• Taken for 1 to 6 months
• May 17, 2017

Movantik (naloxegol) "I was an opiate addict for 24 years been clean for a year. I have always had trouble with constipation. I was taking OTC stool softeners when I'd go 4 or 5 days without going. I would be in so much pain I would literally put a glove on with vaseline and DIG it out. Movantik has been a lifesaver I take 1 every night have coffee in morning and go. Little cramping first couple days but no withdrawals or nausea. I have lost 14 pounds in a month as well. Very happy."

• Cynhow
• October 8, 2017

Movantik (naloxegol) "OMG!! I didn't go to the bathroom for almost a month I did go a little not much than I started to get wicked bad heart burn, so I said let me try the movantik again, within 15 mins I began to sweat profusely I'm not kidding,. I was drenched with sweat and had cramps so bad I thought I died, and the chills I couldn't believe that this could actually do this to someone, and the throwing up was also horrible!! No lie I thought I was puking poop, I was so grossed out and I'm still sweating like no tomorrow and it's been 2 days now since I took a dose of it, I'm glad it works for some but I wouldn't give that to my worse enemy!! That stuff is just horrible!! I've been on methadone for almost 18 years now for back pain failed surgery, fusion and scs failed."

• Dont...
• Taken for less than 1 month
• September 25, 2021

Movantik (naloxegol) "I had been on methadone for about 12 years and my doctor told me I should be having a bowel motions more often then every 10 days (duh) so prescribed me Movantix. Honestly one on the biggest mistakes of my life. I was at work (not a good place to take this!) and within 10 or so minutes I started to have stomach pains. I went to the washroom and sat on the toilet but never had a bm just severe stomach pains. I didn't know what to do I just sat there hunched over. The pains were off and on so when I thought they had stopped I ended up going back to the unit I was working on but the pains hit again and I had to lay down on the floor. FYI I work in a long term care facility. Back to the bathroom I went where the pains eventually went away. I can't even explain how bad this experience was. And now reading all of these reviews that sound exactly like what happened to me. Little bottle costs just under $500. No warnings from my Dr either. Don't take this!"

• LA-jojo
• Taken for 1 to 6 months
• March 10, 2021

Movantik (naloxegol) "After a spinal cord injury I've been taking 40-60 mg of Hydrocodone (Norco) per day. This is not enough to produce withdrawal symptoms on the rare occasion I'm forced to go without but it is enough to make constipation a big deal. I started with the half-dose (12.5mg) and no laxatives. That didn't do much but after a week of experimentation, I was able to reduce the amount of Senna, and Miralax that I use. We just upped the dose to 25 mg/day. I can recommend it for people in similar condition."

• Babyg...
• Taken for less than 1 month
• December 7, 2018

Movantik (naloxegol) "My doctor gave me samples of movantik I have been on pain meds for years also I have to take iron pills cause I am anemic. I have tried taking stool softeners miralax and it doesn't work .I took the movantik the first thing in the morning the first day I got cramps but after that just very little cramping within a couple hours I have a movement with no really no side effects will keep using it. The only thing I am noticing is I have the chills ."

• ChicC...
• Taken for less than 1 month
• May 26, 2018

Movantik (naloxegol) "Hello everyone hope all is well with you and yours. This constipation by far is the worst. I too, have gone almost 3 weeks without relief. To me, it feel's like your poisoning yourself with all your toxic waste just sitting in your body for far too long. That's how I describe it. I get hot, sweaty I turn red like my blood pressure is going through the roof. Just like being poisoned. It starts out with small rock hard waste and then once that first plug that has blocked is gone then I can't stop going. That's when it gets terrible I can't make it to the bathroom. I can't leave the house. I don't dare. What do they use to clean out a patient that is going to have a exam for colon cancer/ or just check up? well I hope they figure this out soon."

• justa...
• Taken for 1 to 6 months
• September 8, 2019

Movantik (naloxegol) "I have been on various mild-moderate pain opiates for 4 weeks for back pain, caused constipation which seemed to be relieved with dulcolax...then back got a lot worse and diagnosed as herniated disc and trapped sciatic nerve with MRI and was first put on 60mg codeine every 4 hours, then liquid morphine 10-15mgs every 2 hours for past 3 weeks...absolutely nothing would work to move my bowels for 3 weeks and I tried everything!!! Eventually in tears at docs she prescribed moventik 25 mg, day one could feel something happening but mostly just gas but day two...hurrah - everything moved!!! No pain no side effects, no cramps - amazing. I am just so so so grateful as was feeling so sick from constipation. Maybe I didn't have side effects people here describe as I haven't developed a physical dependency on opiates after just 6 weeks on them - just complete GI tract shut down. Thank you moventik!!!"

• Nickn...
• Taken for 1 to 6 months
• May 25, 2017

Movantik (naloxegol) "I've been on it for a week & man does it work..Within 15-25 minutes I'm going to the restroom 3 or more times. I take it when I know I have nothing to do for at least & hour or 2 because you don't wanna be running errands when it starts to work as you will never make it home or to a restroom in time. I am on pain medication for 4 failed fusion back surgeries & I was drinking miralax 3 times a day as doctor recommended but I couldn't leave the house because I was always running to the bathroom, when taking this pill I can plan days where I take at hours before my errands & it runs its course before I have to go or I'll take it at night when I know I'm staying home the rest of the night..I have had stomach aches & growling stomach..It does give you some withdrawal.."

• No...
• Taken for 1 to 6 months
• April 4, 2017

Movantik (naloxegol) "I've been on hydrocodine 10/235mg for years and my orthopedic changed me to subutex (generic) I was taking 8 Senokot-s a day for at least 3 days so I could get a small movement and it was hard very hard to get out. So I was told by MD and Pharmacy to try and take Movantik 25mg and now I'm being told to take both Movantik 25 with 2 or 4 Senokot-s cause Movantik isn't working by itself. Anyone else having this problem? I'm on a high fiber diet and I'm drink exactly 140 oz water a day everyday? I rated Movantik 25mg a (3) out of kindness cause I think it needs to be lower."

• Distr...
• November 13, 2017

Movantik (naloxegol) "Within 40 minutes I was in the bathroom with profuse sweating and intense abdominal pain. It is now 5 hours later and the abdominal pain is still there. I wouldn't wish this on my worst enemy. Please take this off the market !"

• Anonymous
• Taken for less than 1 month
• October 19, 2021

Movantik (naloxegol) "I just got a script from my doctor for Movantik. I have been researching its side effects and have literally sat and read every one of these comments about this drug. Now I am scared to take it. What I have noticed while reading and investigating this drug is that it seems to work fine on people who are on oxycodone, oxycontin, etc. But it seems to give people who are on methadone a horrible experience. It sounds as if when Movantik is used with Methadone it causes reciprocated withdrawals. I have had a experience with reciprocated withdrawals and it was the most antagonizing experience ever. So I think I'll pass on this. Thank you all for commenting your experience with this drug. It has definitely helped me in my decision to not even try it."

• Lap
• Taken for 6 months to 1 year
• February 6, 2018

Movantik (naloxegol) "I've been taking Movantik for 8 months. I agree with some of the other reviews in that it worked great initially but eventually lost it's effectiveness. It still helps some, but I have to take Amitiza, Miralax and fiber suppliments along with it. * The main disadvantage for me is it reduces the effectiveness of my pain medication. I notice a huge difference in pain control on the days I take it, my meds don't work as well. For this reason, I usually take 1/2 a tablet instead of the whole thing. I have tried just not taking it at all, but I got very constipated despite the 3 other meds I take to prevent that. So I guess 1/2 a tablet is my happy medium."

• Daily...
• Taken for less than 1 month
• August 3, 2017

Movantik (naloxegol) "I have to take daily opiates due to chronic back pain despite three back surgeries, including lumbar fusion. I tried everything but always would ultimately get backed up. I tried Movantik at one point a couple years ago, but it gave me bad stomach cramps, so I quit. At that time, I had some partial impaction. I recently did a magnesium citrate flush, like prepping for a colonoscopy. I then tried Movatik again and have a bowel movement within an hour or so. I do get some stomach cramps but only for 1-2 hours. Taking 1-2 doses of Miralax a day can help if stool is hard. The big negative is cost."

• griffi
• Taken for less than 1 month
• July 5, 2017

Movantik (naloxegol) "This medication SHOULD NOT be used if a person has had an ORGAN TRANSPLANT. My husband had a heart transplant in October 2016, and was taking opioids from a mechanical heart that was put in between his ribs as a bridge to transplant. He was prescribed Movantic for constipation. He had two weeks of terrible watery diarrhea. After being hospitalized, he was almost in renal failure, and his anti-rejection was off the charts."

• burt
• Taken for 6 months to 1 year
• February 24, 2024

Movantik (naloxegol) "After over 15 years of pain meds. Constipation is also a problem. This medication, initially on a 25 mg dose, was too much. It did work, but with issues like others mentioned. After experimenting, I found for me that initially it was too high a dosage. So, what some people might try, as I did, reduce the dosage to about 6mg. I break it into quarters and take small pieces and actually chew small amounts a couple of times a day. If it doesn't work that afternoon, I use small amounts the following day. By the time I use a quarter to half a pill, it works without all the pain, withdrawal, almost no negative effects. The exception being passing very hard stool. I also found a nighttime dose of Miralax every couple of days helps soften passage. I think for many proper smaller doses will work and give relief. Also, try chewing very small doses. It's not bitter tasting. I'm not sure anyone should try 25 mg to start. I talked to my doctor, told him that dose was horrible. I'm glad I didn't give up. Now it helps without side effects."

• Kandi...
• July 29, 2017

Movantik (naloxegol) "Hi I've been taking movantic once in the morning for a month, and it does nothing for me. I'm so disappointed because I've tried everything. I go 5 to 7 days without bowel movements. I'm at a loss of what to do next I hope my gastro dr. has a plan. The only things I've experienced from movantic are gas and severe cramping. .."

• nyd
• February 8, 2018

Movantik (naloxegol) "movantik was prescribed after fusion lumbar surgery. The drug was $324.00, my share, and it was not effective. The drug was taken as prescribed, on an empty stomach. After 4 days of constipation, other laxatives had to be taken. The pain from the first bowel movement after movantiks had been taken, and induced by other medications, was excruciating."

• Mr Rent
• June 15, 2020

Movantik (naloxegol) "functioning as a PAMORA (Peripherally-Acting Mu-Opioid Receptor Antagonist). Chemically, it is a PEGylated form of naloxone. It does not reverse pain relief primarily due to its inability to cross the blood–brain barrier.3"

• micpro
• June 16, 2020

Movantik (naloxegol) "Movantik works wonders if you are not taking methadone as I was, you can expect immediate withdrawal. The package insert say 76% of methadone trial pts experienced w/d symptoms. I now take morphine and movantik works wonders and causes only occasional discomfort. I can name a quadrillion other reasons to get off long term dolophene. Just sayin'"

• Burt
• Taken for less than 1 month
• March 19, 2022

Movantik (naloxegol) "I have taken opioids for 15 years multiple back injuries and others. I'm getting older and don't move around as much. Anyway I was give 25 mg and tried 1 pill. It was too much. Caused cramping, pain, some diarrhea, but gave relief. I believe it caused withdrawals for days. And though it is not listed as a laxative or fast acting. It was my experience anyway, it was. I tried a third about 8 mg. That also acted fast. After not taking it for 3 days. I'm going to give it a try after another day or 2. This time a quarter or 6 mg max. I feel it will still work. Everyone is different and taking different doses of opiate. If you choose to try this med. I would start with a very low dose. While at home. And be sure to save your pain med till after. Or take it long enough before it doesn't completely leave you in withdrawals. My half dose left me feeling worse than the constipation days later. I think that's what it was. So my final opinion. It can work. But needs to be better regulated than prescribed."

• Lap
• Taken for 6 months to 1 year
• January 2, 2018

Movantik (naloxegol) "I've been on Movantik for 6 months now. The medicine worked great the first week or so, but eventually it stopped working all together. I take Amitiza, Miralax and an OTC herbal supplement along with Movantik for OIC. When I started PM this summer, I was taking up to 2-3 Percocet 5mg a day. Now I'm taking up to 4 Percocet 10mg per day. I was upset at how quickly I had built a tolerance. I thought it may have been the particular brand I was taking, so I switched pharmacies. I found no matter what brand I took, they didn't work very well or last long. A few days ago, I decided to stop Movantik to see if my pain medicine would work better. Boy was I right! It has been more potent and lasts much longer than usual. Don't waste your $$"

• JIM
• Taken for less than 1 month
• January 13, 2024

Movantik (naloxegol) "I am taking 60mg Morphine ER with another 30mg IR as needed. I was doing well with OTC 24.8mg Sennosides with 150mg Docusate at 5:00 PM and getting up 2 hours prior to leaving the house. It was rare for me to not have a BM unless I forgot to take my laxative, in which case I increased my dosage by 33% the next day. I told my pain doctor this in case other patients might wish to try my method. She informed me that while it was cool that I monitored myself closely, general laxatives such as these were meant for occasional rather than daily use and could be addictive. We have great trust towards one another since my philosophy is that a doctor cannot properly treat me if I'm not open with them. She told me about Movantik and that it blocks the opiates' attachment to receptors in the stomach. I had cramps on day 1, but since then no problems as I followed the directions exactly. A perfect 10. Ooh Rah."

• lites...
• March 1, 2021

Movantik (naloxegol) "Hi, Here is my experience. I take 60 mg of oxy and take 10mg methadone (slow withdrawal from 17yr of prescribed methadone). I get less withdrawal symptoms if I take 1 hour before eating always first thing in the morning. Today I had bad symptoms because I had food with pill and it really shook me up with bad withdrawal symptoms. I try to take this every other day and take miralax night before movantik dose. Give this drug at least 1-2 hrs to work in morning BEFORE pain meds. This will give drug time to be absorbed and block the receptors that cause constipation. Empty stomach is real critical too! Alternative is warm water enemas every 2 days."