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Tirosint and Weight Gain: What Users Say

Weight gain: mentioned by 13 users (9.3%)

Based on user experiences from 140 Tirosint reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

hair loss 12.9%
fatigue 9.3%
weight gain 9.3%
anxiety 8.6%
insomnia 8.6%
headaches 6.4%
chest pain 5.7%
swelling 5.7%
heart palpitations 5.0%
dizziness 4.3%

Reviews for Tirosint

Commonly mentioned side effects
  • ACB...
  • May 12, 2013

For Hashimoto's disease "I was affected by the Levoxyl recall and was devastated. I had been on Levoxyl for Hashimoto's for about 3 years, it was the only thyroid med that made me feel what I thought at the time was 'good'. Looking back, I wasn't good at all...no sex drive, weight gain, swollen face, extreme anxiety. I switched to Tirosint about a month ago, and when I noticed these side effects dissipating, I was ECSTATIC but also so confused! I had no idea the Levoxyl was causing so much negativity in my life. Tirosint has NO fillers, and for that reason, all those negative side effects from Levoxyl were gone. I dropped 5 lbs almost immediately, taking me back to my post-Hashimoto's weight. Sex drive was back, anxiety decreased. Best of all, I'm just happy again!"

10 / 10
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326 Report
  • DCG...
  • Taken for 5 to 10 years
  • June 28, 2020

For Hypothyroidism, After Thyroid Removal "I went on Tirosint when Levoxyl stopped working after they changed the formulary. It worked great until March or so of this year. Now my hair is falling out, I’ve gained 8 lbs., my temp is 96, I’m exhausted, etc. Because of the pandemic, I didn’t figure it out right away. Obviously hypothyroidism and I’m so bummed. Awaiting test results and a consult with my doctor. What did they do to Tirosint? Synthroid or Levoxyl don’t work for me. What do I do next? What a nightmare."

1 / 10
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90 Report
  • And...
  • October 10, 2018

For Underactive Thyroid "I have Graves' disease and took RAI (radioactive iodine (I-131)) to treat the disease, which means now I have to top up my thyroid levels. I've previously taken Levoxyl, Synthroid, and lastly Armour. I always felt miserable with Levoxyl and Synthroid, which is why for the last three years I was taking Armour. Within the last year of taking Armour, I've had terrible inflammation, joint pain, anxiety, insomnia, hair loss, dry skin, weight gain, and the list goes on. It was coincidental that I forgot to take an Armour pill and realized how in one day all my symptoms went away. The next day I took my Armour and they all returned. It was so bad that I couldn't even bend my knees. I was miserable! I've been reading about Tirosint for the last few months, and my endo was more than accommodating to let me try it. WOW! What a difference! I'm not as hungry, losing weight, no anxiety, sleeping through the night, and overall just feeling great, as I've never had thyroid issues. However, I did have some heart palpitations last night. I'm going to get my lab work done today, as I feel the dosage may be too high."

10 / 10
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81 Report

Frequently asked questions

  • Lov...
  • Taken for less than 1 month
  • November 23, 2016

For Hypothyroidism, After Thyroid Removal "I was on levothyroxine for a year after my cancer surgery/thyroid removal. It was the worst year of my life. I was seriously hating life because I hurt every single day. Muscle aches, swelling, every symptom you can imagine. Weight gain was the worst. I fired my endo and waited two months to see the new one. If I wasn't married, I'd propose to the man. In three weeks, my life has changed. I can go to the gym and not feel like I have been hit by a truck. No muscle aches. I have lost 9 lbs. Brain fog is lifting. I sleep better, and I don't feel like a 47-year-old stuck in a 90-year-old body. I will pay ANY amount of money, and I will NEVER go back."

10 / 10
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98 Report
  • bba...
  • Taken for less than 1 month
  • April 20, 2020

For Underactive Thyroid "I have been on several thyroid medications for over 8 years. I was always tired, had fatigue, experienced hair loss, and extreme weight gain. I started Tirosint, and instantly I started feeling better."

10 / 10
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68 Report

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  • Mim...
  • Taken for less than 1 month
  • September 19, 2018

For Hashimoto's disease "I've tried several different thyroid meds for Hashimoto's, and this is the worst I've felt by far! I couldn't go to the bathroom, couldn't eat, couldn't sleep, felt a lump in my throat, gained weight, was freezing cold, and ended up in the ER because of my stomach pains. I switched back to Armour Thyroid, but now need to see a gastroenterologist because my stomach is still suffering because of that dreaded Tirosint!!!!!"

1 / 10
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44 Report
  • Mis...
  • August 29, 2020

For Hypothyroidism, After Thyroid Removal "I was on name brand Synthroid from 2008 until 2019, my doctor switched me to Tirosint thinking that I would have less heart palpitations and better absorption. I was on 200 mcg of Synthroid, TSH was 0.01, I am now on 112 mcg of Tirosint with a TSH of 0.1. I gained a significant amount of weight, so my endo doctor added 5 mcg of T3, I have not lost any of the weight. Since starting Tirosint, my weight has increased from 116 lbs to 130-131. I exercise and move a lot and do watch what I eat, although I do allow sweets in moderation as I always have. I have also noticed an increase in hair loss, a lot of hair loss, and very dry hair, thankfully, I have thick hair, but the dryness is awful. Long story short, I don't believe Tirosint is the right medication for me as I have gained so much weight and lost a large amount of hair, even with the added T3, which didn't help to change the weight issues. I will be requesting to go back to name brand Synthroid with the added T3 to see if this helps."

3 / 10
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31 Report

More FAQ

  • Jou...
  • February 20, 2017

For Hashimoto's disease "I was started on levothyroxine, then Armour, and my symptoms were worse than before medication. Tirosint literally gave me my life back. Then new insurance made me try Nature-Throid. Back to the same misery that plagued me the better part of the year. Whatever the cause or effect in chemistry, I am immediately changing back. Brain fog, sore muscles, lethargy, fatigue, constant hunger, weight gain. Never again will I try another medicine."

10 / 10
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45 Report
  • Doe...
  • Taken for 6 months to 1 year
  • May 7, 2018

For Hashimoto's disease "I thought this med would be my silver bullet! I was so relieved and excited to try it. Five months in and no difference whatsoever! Even after multiple increases in dosage. Terribly disappointing as I had to fight to get it with insurance, etc., etc., etc. and it is not cheap! I feel I am out of options as generic levo did nothing and I’ve also tried Unithroid and Armor, which was worse than all of them combined! Armor is not worth all the praise it receives. I’m at a loss now. Gained over 25 MORE pounds on this Tirosint!"

2 / 10
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37 Report
  • nan...
  • Taken for 1 to 6 months
  • July 21, 2019

For Hashimoto's disease "First of all, there are coupons for this, and I pick it up from Walmart for 28.30. Search coupons free for Tirosint. I first tried a company that is a scam company. They charged me 50 dollars, saying my medication was going to be 60 a month. Too late, I gave the scumbags my credit card and forget this bogus company out of Florida. The medication doesn't work for me, my hair falls out, I'm tired, and I'm gaining weight, so I'm going back to a compound which worked for me in the past. Good luck everyone with this. Uggh."

1 / 10
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38 Report
  • Tir...
  • Taken for 5 to 10 years
  • June 24, 2024

For Hashimoto's disease "I've been taking Tirosint since 2013. It changed my life. I attempted to go back to Synthroid and completely went backwards in my treatment, which caused my metabolism to slow down and my organs weren't functioning well. I'll never change from Tirosint again. I did have an issue when it changed to Tirosint or whatever the company is called, and the taste was horrible. I relapsed to the point I had to take time off of work. I gained 25 lbs within 4 months. I'm still fighting to get myself back to normal. I did report it. Hoping things change soon since I'm fighting harder than ever to feel the way I did before the changes. Insurance sometimes covers a small amount, but it's mostly out of pocket."

8 / 10
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4 Report
  • drr...
  • November 15, 2017

For Underactive Thyroid "I switched over to Tirosint after taking levothyroxine for the past two years. It worked for me, I felt great and energetic. The only downside after switching is that I gained at least 10-15 lbs, and my face has gotten puffy. I hate it. My insurance won’t cover the dose I’m on (150 mcg), and it’s just way too expensive out of pocket. I believe my last refill was around $150, the pharmacy was able to bring it down to $113, which is still a lot for only a 28-day supply. I just switched to Armour Thyroid (90 mg). Hopefully, that will help with the weight loss, it’s also NDT, which is another good alternative if you prefer the natural route."

9 / 10
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18 Report
  • Anonymous
  • Taken for 1 to 6 months
  • June 7, 2017

For Hashimoto's disease "I was on Synthroid 50 mcg and generic levothyroxine 50 mcg. With both medications, I had palpitations, heat intolerance, and severe insomnia. Synthroid was worse than levothyroxine. My TSH numbers were fine, but I couldn't tolerate the insomnia. The positive thing was that I lost 30 pounds. I was switched to Tirosint 50 mcg and immediately could finally sleep. No more insomnia, no more palpitations, no more heat intolerance. I recently got my lab work back, and I have a normal TSH, but I've started getting hypothyroid-like symptoms I used to have when I was on no thyroid medication. So even though my TSH is normal and I can sleep, I am having weight gain, increased constipation, and hairline eczema. Alas, I will try another brand!"

9 / 10
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19 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.