Skip to main content

Tirosint and Insomnia: What Users Say

Insomnia: mentioned by 12 users (8.6%)

Based on user experiences from 140 Tirosint reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

hair loss 12.9%
fatigue 9.3%
weight gain 9.3%
anxiety 8.6%
insomnia 8.6%
headaches 6.4%
chest pain 5.7%
swelling 5.7%
heart palpitations 5.0%
dizziness 4.3%

Reviews for Tirosint

Commonly mentioned side effects
  • And...
  • October 10, 2018

For Underactive Thyroid "I have Graves' disease and took RAI (radioactive iodine (I-131)) to treat the disease, which means now I have to top up my thyroid levels. I've previously taken Levoxyl, Synthroid, and lastly Armour. I always felt miserable with Levoxyl and Synthroid, which is why for the last three years I was taking Armour. Within the last year of taking Armour, I've had terrible inflammation, joint pain, anxiety, insomnia, hair loss, dry skin, weight gain, and the list goes on. It was coincidental that I forgot to take an Armour pill and realized how in one day all my symptoms went away. The next day I took my Armour and they all returned. It was so bad that I couldn't even bend my knees. I was miserable! I've been reading about Tirosint for the last few months, and my endo was more than accommodating to let me try it. WOW! What a difference! I'm not as hungry, losing weight, no anxiety, sleeping through the night, and overall just feeling great, as I've never had thyroid issues. However, I did have some heart palpitations last night. I'm going to get my lab work done today, as I feel the dosage may be too high."

10 / 10
Was this helpful?YesNo
81 Report
  • Lov...
  • Taken for less than 1 month
  • November 23, 2016

For Hypothyroidism, After Thyroid Removal "I was on levothyroxine for a year after my cancer surgery/thyroid removal. It was the worst year of my life. I was seriously hating life because I hurt every single day. Muscle aches, swelling, every symptom you can imagine. Weight gain was the worst. I fired my endo and waited two months to see the new one. If I wasn't married, I'd propose to the man. In three weeks, my life has changed. I can go to the gym and not feel like I have been hit by a truck. No muscle aches. I have lost 9 lbs. Brain fog is lifting. I sleep better, and I don't feel like a 47-year-old stuck in a 90-year-old body. I will pay ANY amount of money, and I will NEVER go back."

10 / 10
Was this helpful?YesNo
98 Report
  • Jo ...
  • Taken for 2 to 5 years
  • July 8, 2018

For Underactive Thyroid "For underactive thyroid, I was first given Synthroid. I had very bad side effects, which included feeling very hyped up, terrible insomnia, and anxiety out the roof. I felt crazy, like I was on street drugs or something! Horrible experience that went on for many weeks. I finally was able to see an endo, who right away put me on Tirosint. Wow, what a difference! No side effects. It took almost one year to get my levels right and my medication dose settled in, but it was worth it. In the short term, I felt much better after about a month. My doctor says the dyes and other fillers could have been causing my previous reaction. I am super sensitive to drugs and will not take over-the-counter meds or anything because of this. Tirosint is worth the extra cost if you are having problems like mine. They do offer a $35.00 coupon good for 18 months online if insurance won't pick up the cost."

10 / 10
Was this helpful?YesNo
59 Report

Frequently asked questions

  • atr...
  • Taken for 6 months to 1 year
  • September 21, 2013

For Underactive Thyroid "I was on Tirosint for over 6 months, and during that time, I've had fluctuating blood pressure, a sore neck and throat, sleepless nights, nervousness, and generally not feeling well. While it may work for some, it didn't work for me. I am now on the natural hormone Armour Thyroid, and I hope to stay on it."

1 / 10
Was this helpful?YesNo
101 Report
  • 24a...
  • August 19, 2013

For Hypothyroidism, After Thyroid Removal "I started Tirosint after Levoxyl was taken from the market. It is the best. I take this in combination with Liothyronine. Aside from insomnia, which I have experienced with every other medicine as well, and I've taken them all, this is the best I've felt in years."

9 / 10
Was this helpful?YesNo
90 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • Lau...
  • Taken for 1 to 2 years
  • December 13, 2023

For Hashimoto's disease "I am on Tirosint and also Armour. I cannot sleep, and my fingernails stay horrible. My TSH fluctuates. I feel better when it’s around 2.0, mine is 3.93. I fight fatigue and mentally lack ambition. I wonder if others have this same complaint."

3 / 10
Was this helpful?YesNo
11 Report
  • Bin...
  • Taken for 1 to 6 months
  • April 10, 2018

For Underactive Thyroid "I was excited to switch from Synthroid to Tirosint because my doctor told me that it was gluten-free compared to other medications. I have been on it for a little over a month after switching from Synthroid, and I feel so terrible: anxiety, insomnia, fatigue, lots of hair loss, and weight is stuck, and my goiter in my neck is enlarged again. I called my doctor because I want to go back on my Synthroid. I did read that some people do better on it than others, and I believe it is just not for me."

1 / 10
Was this helpful?YesNo
30 Report

More FAQ

  • AAa...
  • Taken for 6 months to 1 year
  • June 1, 2020

For Underactive Thyroid "I have had an underactive thyroid for 8 years. I could not handle Synthroid and was always going off. I like Tirosint, at first, I am only on a small dosage of 13, but my hair was falling out so badly that I started taking 2 pills during Corona because of no doctor. It stopped hair breakage, but if I take too much, I get headaches and have trouble sleeping. But now if I take 13 only, I get bad depression and my hair falls out again. Overall, I like the meds. I am diagnosed with Hashimoto's, and this is just my life-my own thyroid not being regulated. I have a bad headache today, so I can't take 2 tomorrow, so I guess I can prep for severe depression. Oy vey!"

9 / 10
Was this helpful?YesNo
24 Report
  • Sle...
  • February 17, 2012

For Hypothyroidism, After Thyroid Removal "This is the third medication I have been on since my thyroid removal. Tirosint seems smoother than Synthroid. However, I have had a lot of gastrointestinal issues and sleep issues while on Tirosint. My quality of life is now very poor. Since Tirosint is better than the other two medications I tried, I will remain on it."

5 / 10
Was this helpful?YesNo
51 Report
  • Anonymous
  • Taken for 1 to 6 months
  • June 7, 2017

For Hashimoto's disease "I was on Synthroid 50 mcg and generic levothyroxine 50 mcg. With both medications, I had palpitations, heat intolerance, and severe insomnia. Synthroid was worse than levothyroxine. My TSH numbers were fine, but I couldn't tolerate the insomnia. The positive thing was that I lost 30 pounds. I was switched to Tirosint 50 mcg and immediately could finally sleep. No more insomnia, no more palpitations, no more heat intolerance. I recently got my lab work back, and I have a normal TSH, but I've started getting hypothyroid-like symptoms I used to have when I was on no thyroid medication. So even though my TSH is normal and I can sleep, I am having weight gain, increased constipation, and hairline eczema. Alas, I will try another brand!"

9 / 10
Was this helpful?YesNo
19 Report
  • Anonymous
  • Taken for 1 to 6 months
  • September 8, 2021

For Hashimoto's disease "Horrible medication. As a 65-year-old with a recent diagnosis of Hashimoto's disease, I was on this drug for 2 months. The second month, things got worse. Chest pains, not sleeping, terrible muscle aches. Well, I ended up in the emergency room with chest pains, which led to a triple bypass operation! This drug should be off the market!"

1 / 10
Was this helpful?YesNo
15 Report
  • Gka...
  • July 17, 2019

For Underactive Thyroid "Was put on Tirosint, but it caused me major anxiety, weakness, and insomnia. Do not recommend."

1 / 10
Was this helpful?YesNo
56 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.