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Tirosint and Fatigue: What Users Say

Fatigue: mentioned by 13 users (9.3%)

Based on user experiences from 140 Tirosint reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

hair loss 12.9%
fatigue 9.3%
weight gain 9.3%
anxiety 8.6%
insomnia 8.6%
headaches 6.4%
chest pain 5.7%
swelling 5.7%
heart palpitations 5.0%
dizziness 4.3%

Reviews for Tirosint

Commonly mentioned side effects
  • Anonymous
  • Taken for 1 to 2 years
  • July 26, 2019

For Underactive Thyroid "I was doing great on Tirosint until manufacturers changed to IBSA. I developed gastritis and arthritic neck pain, fatigue, and weakness. Felt like I had the flu. This medication has cost me a lot of time and money. Please start checking for any manufacture changes to your thyroid medication."

1 / 10
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  • Bos...
  • Taken for 5 to 10 years
  • August 31, 2019

For Hypothyroidism, After Thyroid Removal "Been on Tirosint for 7 years after switching from other forms of levothyroxine. Been doing great on it, with small dose changes when needed. 4 months ago, was feeling unwell, endo tested me & my TSH was highest it's been since before I started Tirosint. We increased my dose, I'm now worse with full hypo symptoms that are affecting all areas of my life & functioning (intense pain, fatigue, brain fog, menstrual issues, etc.). Just had my thyroid panel & my TSH has climbed HIGHER on a Tirosint dose increase - opposite of what should be happening. Hasn't been this high since my thyroid was removed. I contacted the Tirosint manufacturer to see if the formulation has changed - NO RESPONSE. Will contact all the necessary channels to find out what's going on. It seems obvious that it must be the meds, since my issues coincide with their packaging & capsule sizes changing. I'm livid that they haven't responded. People's lives are at stake. Those without thyroids NEED effective hormone replacement to LIVE."

6 / 10
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153 Report
  • DCG...
  • Taken for 5 to 10 years
  • June 28, 2020

For Hypothyroidism, After Thyroid Removal "I went on Tirosint when Levoxyl stopped working after they changed the formulary. It worked great until March or so of this year. Now my hair is falling out, I’ve gained 8 lbs., my temp is 96, I’m exhausted, etc. Because of the pandemic, I didn’t figure it out right away. Obviously hypothyroidism and I’m so bummed. Awaiting test results and a consult with my doctor. What did they do to Tirosint? Synthroid or Levoxyl don’t work for me. What do I do next? What a nightmare."

1 / 10
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90 Report

Frequently asked questions

  • pat...
  • July 24, 2013

For Underactive Thyroid "Tirosint has been great for me. I have hypothyroidism and was starting to have recurring symptoms. Tirosint got rid of these symptoms. My recurring symptoms while on Levoxyl (but only after over ten years on it) were: puffy face, constipation, fatigue. When I took Tirosint, the symptoms were gone. I am very happy with Tirosint. I have no side effects."

10 / 10
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170 Report
  • bba...
  • Taken for less than 1 month
  • April 20, 2020

For Underactive Thyroid "I have been on several thyroid medications for over 8 years. I was always tired, had fatigue, experienced hair loss, and extreme weight gain. I started Tirosint, and instantly I started feeling better."

10 / 10
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68 Report

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  • Kat...
  • Taken for 1 to 2 years
  • June 12, 2019

For Hypothyroidism, After Thyroid Removal "I have been on Tirosint for 21 months along with a T3 only med. But for the past month, I have been exhibiting hypo symptoms when nothing else has changed. This is for the 100 mcg dosage. I called the number on the box and reported my symptoms. The woman said she has been getting other complaints recently, too. What's important to note is that in December 2018, Tirosint changed distributors. I think there is a batch consistency issue. I am sleeping 12 hours a night, having depression (nothing changed in my life), increased joint pain, and severe fatigue. The only reason I rated it an 8 is because for the first year and a half, with the old distributor, I had no issues. I REALLY don't want to change thyroid meds again. That would be devastating."

8 / 10
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  • Jou...
  • February 20, 2017

For Hashimoto's disease "I was started on levothyroxine, then Armour, and my symptoms were worse than before medication. Tirosint literally gave me my life back. Then new insurance made me try Nature-Throid. Back to the same misery that plagued me the better part of the year. Whatever the cause or effect in chemistry, I am immediately changing back. Brain fog, sore muscles, lethargy, fatigue, constant hunger, weight gain. Never again will I try another medicine."

10 / 10
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45 Report

More FAQ

  • She...
  • April 6, 2015

For Underactive Thyroid "I have been on one form of hypothyroid meds for the last 20 years. I have used Tirosint for a year and a half. The only thing that I can say for it is the doctor loves it. I hate it. I was hoping it would help with my fatigue, swelling, and forgetfulness. The only thing that has changed for me is my cheeks are redder, I feel bloated all the time, and I am losing my hair. I'm still tired and still think I'm losing my mind. Logical worked better than all of them, including the Armui."

6 / 10
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59 Report
  • Lau...
  • Taken for 1 to 2 years
  • December 13, 2023

For Hashimoto's disease "I am on Tirosint and also Armour. I cannot sleep, and my fingernails stay horrible. My TSH fluctuates. I feel better when it’s around 2.0, mine is 3.93. I fight fatigue and mentally lack ambition. I wonder if others have this same complaint."

3 / 10
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  • Bin...
  • Taken for 1 to 6 months
  • April 10, 2018

For Underactive Thyroid "I was excited to switch from Synthroid to Tirosint because my doctor told me that it was gluten-free compared to other medications. I have been on it for a little over a month after switching from Synthroid, and I feel so terrible: anxiety, insomnia, fatigue, lots of hair loss, and weight is stuck, and my goiter in my neck is enlarged again. I called my doctor because I want to go back on my Synthroid. I did read that some people do better on it than others, and I believe it is just not for me."

1 / 10
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  • Lyd...
  • Taken for 5 to 10 years
  • July 3, 2018

For Underactive Thyroid "I've been on Tirosint for over 6 years now. I tried Synthroid and even Armour. Nothing worked until Tirosint. I started with 25 mcg and went up to 50 mcg and have been on 50 mcg like forever. My levels went from 14 to 8, then to 6, then to 4. Then I went back up to 8 and my doctor increased me to 75 mcg. Well, I thought I was going to die. The headaches, the fatigue, seeing spots, feeling dizzy, stomach discomfort, etc. Then some kind of lump developed on the right side of my neck. Like some kind of alien moving along my neck line & as it was happening, I called for my husband and said, 'What is that thing!!!!' So, I just put myself back on the 50 mcg and within 2 weeks felt better but not totally better. I think by increasing my med to 75 mcg was not a good plan by my doctor. I always say if it isn't broke, don't fix it!!!"

9 / 10
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31 Report
  • Bel...
  • Taken for less than 1 month
  • January 26, 2017

For Underactive Thyroid "My doctor switched me on Monday to Tirosint from levoxyl, and after 4 days, I'm going back to my old medicine, and I thank God I still have some because I can't go another day with these headaches, fatigue, and muscle aches. I've been on levoxyl, Synthroid, and levoxyl, and none have made me feel this horrible. I was planning on dealing with it to see if the symptoms would go away, but I work doing payroll and taxes, and this medicine is making me work really slow and making errors, so I don't have the luxury to wait and see if, in time, I feel better. What I don't understand, from what I've been reading, is that this is a more pure form of levoxyl, so if he's giving the same dosage, wouldn't it mean he's overmedicating me? I haven't talked to him yet."

1 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • March 9, 2021

For Underactive Thyroid "In February, I was switched from name-brand Synthroid to Tirosint 25 mcg. I also take Cytomel 5 mcg. Since then, a month later, I am fatigued, pain in joints, especially in hands, wrists, legs, ankles, and very irritable. I'm not sure if Tirosint is the cause, but nothing has really changed to make me feel like this. I'm guessing it has to be from Tirosint."

2 / 10
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16 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.