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Levoxyl

Generic Name: levothyroxine (LEE voe thye ROX een)
Brand Names: Levoxyl, Synthroid, Tirosint, Unithroid

Medically reviewed by P. Thornton, DipPharm. Last updated on Dec 11, 2018.

What is Levoxyl?

Levoxyl (levothyroxine) is a thyroid medicine that replaces a hormone normally produced by your thyroid gland to regulate the body's energy and metabolism. Levothyroxine is given when the thyroid does not produce enough of this hormone on its own.

Levoxyl is used to treat hypothyroidism (low thyroid hormone).

Levoxyl is also used to treat or prevent goiter (enlarged thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or cancer.

Important Information

You may not be able to take Levoxyl if you have certain medical conditions. Tell your doctor if you have an untreated or uncontrolled adrenal gland disorder, a thyroid disorder called thyrotoxicosis, or if you have any recent or current symptoms of a heart attack.

Levoxyl should not be used to treat obesity or weight problems. Dangerous side effects or death can occur from the misuse of this medicine, especially if you are taking any other weight-loss medications or appetite suppressants.

Before taking this medicine

Levoxyl should not be used to treat obesity or weight problems. Dangerous side effects or death can occur from the misuse of levothyroxine, especially if you are taking any other weight-loss medications or appetite suppressants.

Since thyroid hormone occurs naturally in the body, almost anyone can take levothyroxine. However, you may not be able to take this medicine if you have certain medical conditions. Tell your doctor if you have:

  • an untreated or uncontrolled adrenal gland disorder;

  • a thyroid disorder called thyrotoxicosis; or

  • symptoms of a heart attack (chest pain or heavy feeling, pain spreading to the jaw or shoulder, nausea, sweating, general ill feeling).

Tell your doctor if you have ever had:

  • a thyroid nodule;

  • heart disease, a blood clot, or a blood-clotting disorder;

  • diabetes (insulin or oral diabetes medication doses may need to be changed when you start taking Levoxyl);

  • kidney disease;

  • anemia (lack of red blood cells);

  • osteoporosis, or low bone mineral density;

  • problems with your pituitary gland; or

  • any food or drug allergies.

Tell your doctor if you have recently received radiation therapy with iodine (such as I-131).

If you become pregnant while taking Levoxyl, do not stop taking the medicine without your doctor's advice. Having low thyroid hormone levels during pregnancy could harm both mother and baby. Your dose needs may be different during pregnancy.

Tell your doctor if you are breast-feeding. Your dose needs may be different while you are nursing.

Do not give this medicine to a child without medical advice.

How should I take Levoxyl?

Take Levoxyl exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Levoxyl works best if you take it on an empty stomach, at least 30 to 60 minutes before breakfast. Follow your doctor's dosing instructions and try to take the medicine at the same time each day.

Swallow the tablet with a full glass (8 ounces) of water. The Levoxyl tablet may dissolve very quickly and could swell in your throat.

Levothyroxine doses are based on weight in children. Your dose needs may change if you gain or lose weight.

It may take several weeks before your body starts to respond to levothyroxine. Keep using this medicine even if you feel well. You may need to use Levoxyl for the rest of your life.

You may need frequent medical tests. Tell any doctor, dentist, or surgeon who treats you that you are using Levoxyl.

Store at room temperature away from moisture and heat.

Do not share this medicine with another person, even if they have the same symptoms you have.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache, leg cramps, tremors, feeling nervous or irritable, chest pain, shortness of breath, and fast or pounding heartbeats.

What should I avoid while taking Levoxyl?

Avoid the following food products, which can make your body absorb less levothyroxine: grapefruit juice, infant soy formula, soybean flour, cotton seed meal, walnuts, and high-fiber foods.

Levoxyl side effects

Get emergency medical help if you have signs of an allergic reaction to Levoxyl: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fast or irregular heartbeats;

  • chest pain, shortness of breath;

  • fever, hot flashes, sweating;

  • tremors, or if you feel unusually cold;

  • weakness, tiredness, sleep problems (insomnia);

  • memory problems, feeling depressed or irritable;

  • headache, leg cramps, muscle aches;

  • feeling nervous or irritable;

  • dryness of your skin or hair, and/or hair loss;

  • changes in your menstrual periods; or

  • vomiting, diarrhea, appetite changes, weight changes.

Certain side effects may be more likely in older adults.

Common Levoxyl side effects may include:

  • muscle weakness;

  • headache, leg cramps;

  • nervousness, trouble sleeping;

  • diarrhea; or

  • skin rash, partial hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Levoxyl?

Many other medicines can be affected by your thyroid hormone levels. Certain other medicines may also increase or decrease the effects of levothyroxine.

Certain medicines can make levothyroxine less effective if taken at the same time. If you use any of the following drugs, avoid taking them within 4 hours before or 4 hours after you take Levoxyl:

Many drugs can interact with levothyroxine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Levoxyl only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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