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User Reviews for Spravato

Condition Avg. Rating Reviews Compare
Major Depressive Disorder   8.5
6 reviews 47 medications
Depression   5.2
38 reviews 81 medications

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Spravato

Lee · Taken for 6 months to 1 year January 4, 2021

For Major Depressive Disorder: “My first treatment was February 7, 2020 and my life has been completely changed thanks to this medication. For one thing it has given me hope that there are new treatments to fight depression. The best thing is it is working! I no longer stay in bed all the time. I have more energy and I enjoy living life again. As far as the treatments themselves I get a feeling of euphoria for the first 40 minutes. My face, lips and nose have a very numb feeling which goes away within about 2 hours. Some days after my treatment I feel fatigued and some days I have a good amount of energy. For me watching funny videos/comedians/movies on my iPad help me not to dwell on the results of my treatment when coming down from the "high". Personally this medication is a blessing and it has given me my life back.”

10 / 10
Makepeace · Taken for 1 to 6 months December 20, 2020

For Major Depressive Disorder: “Suicidal depression has plagued me since before I could even conceived of it — probably very much like gender. A panoply of medicines, always with Cylert or Ritalin, provided a substantial modicum of relief for decades. However, consciousness continued to be unbearably painful and a craving for self-annihilation became my default. One week of the higher-dose treatment (3 containers) remains and, while I am not elated, the constant suicide hunger is gone. I don’t yet know if it facilitates pleasure but it does stop the death default.”

10 / 10
Gent · Taken for 1 to 6 months December 15, 2020

For Major Depressive Disorder: “I’ve dealt with depression for over 40 years and have been on most medications. This is the first time I’ve felt on the path to the true me, free of the clouds. This has literally saved my life. While I chose MDD as the condition, I am more accurately Treatment Resistant Depression.”

10 / 10

Frequently asked questions

John S · Taken for 1 to 6 months December 15, 2020

For Major Depressive Disorder: “Once the sedative effects are no longer felt you go back to being able to suppress your thoughts that you don't want to think about. It worked until my body got used to it.”

6 / 10
First Treatment · Taken for less than 1 month November 23, 2020

For Major Depressive Disorder: “Had my first Spravato treatment today. The high feeling lasted about 45 minutes. It felt like my legs were separated from my body. I felt really happy. Coming down was not very fun. I started to feel sad again. I’m not giving up though. Going to keep going.”

7 / 10
AME November 18, 2020

For Depression: “I have been doing Spravato treatments for approximately 10 weeks (for bipolar) and I, and everyone who knows me, have seen a wonderful improvement in mood and energy. Prior to starting treatments, I had been sleeping 16+ hours a day and had little motivation to accomplish even basic self-care. Now my sleep is about 9 hours a night and I wake up ready to set and accomplish goals. Having bipolar disorder, I am hypervigilant about not getting manic and so far no manic episodes, just healthy increased energy. Due to my improved condition, I am currently enrolled in three online courses which I am thoroughly enjoying - this would not have been fathomable just three short months ago. Yes, the 2 hours during treatment can be a bit "trippy"and uncomfortable, and I agree with other posters, surround yourself with comforting, soothing things. Listen to soft music, wear comfortable clothes or watch uplifting videos.”

9 / 10
MISSY October 31, 2020

For Depression: “I have mixed feelings about this drug. This has taken the suicidal thoughts and squashed it, My depression is very little I really don't like the treatment - feeling spaced out for 45 mins. I've had high heart rate, dizzy, sickness, headaches, The BIGGEST most important part of this treatment is take no medications the night before and day of treatment, don't drink the night before or you will pay for it with super sickness and panic attacks and high heart rate. Everyone is different with this treatment don't think its going to be fun cuz its not. But verses being dead, it was worth the try!! I had to find this out on my own, the Drs don't tell you much about what and what not to do when you take this medication. Most important put yourself in a calm state during, I found playing soft music is a must, and try not to get up during or it will cause you to be dizzy and sick. Wait at least 45 mins after when it wears off. I hope this helps someone.”

7 / 10

More FAQ

Anonymous · Taken for 1 to 2 years October 6, 2020

For Major Depressive Disorder: “The Spravato nasal spray literally saved my life and I did it for a year straight. I did end up overdosing by taking it with tramadol that I was given for pain from my third hip surgery that I had no idea it would interact with. I only got to the 2nd spray before I had to spray the other into the trash to act like I used it cause they refused to believe I had ODED. I stopped going back for that unless for emergencies. It was perfectly fine for a year and I felt as if I could live. I used to do acid when I was younger so tripping never scared me. It is a huge experience for anyone wanting to try it but if you're at wits end, I'd say go for it. It worked for me. Just remember that tramadol is a MAJOR interaction and both kratom and klonopin/xanax will make the Spravato less effective when using it. Hope this helps for anyone wanting to try.”

8 / 10
Jimmy September 6, 2020

For Depression: “Been on 84mg for over a year. Cutting to every two weeks soon. It's more intense than the IV version and nowhere near as good as micro dosing mushrooms. Sorry Janssen. Waiting for the phase 3 trials of psylocybin to complete and I'm all in. I want a cure, not games.”

5 / 10
Laly September 2, 2020

For Depression: “I suffer from depression. I’ve tried different meds and none have seemed to help. I heard of Spravato and was very excited to know there was a treatment out there that could work. I’ve done 6 sessions of Spravato and have seen no improvement. I have an appointment tomorrow for another treatment. I really don’t like the experience. As you inhale the Spravato you get the nasty taste. Then you’re in for a ride of feeling like you’re outside your body. Feeling like you’re completely numb. Face feet etc. I hate the whole experience. Everyone is different. I hope this works for others that are going to try this. Good luck!”

2 / 10
Calif619 · Taken for less than 1 month September 1, 2020

For Depression: “I’ve had 5 Spravato treatments so far for depression. I felt a lightening of my mood after the first three treatments, however the feeling didn’t last long maybe 24 hours. I’m hopeful that with continued treatments I will improve. I don’t have a strong reaction to the medication when it’s administered, just a slight disassociation with time and place that I can easily bring into perspective. The nasal spray dripping down your throat is horrible and I take zofran and omeprazole before my appointments to counter. I had 15 ketamine injections a year ago and they helped a little. I’ve yet to have an infusion. I know that is the gold standard but I cannot afford it financially.”

2 / 10
Cat · Taken for 1 to 6 months August 11, 2020

For Depression: “I have Bipolar, untreatable depression, BPD. I have done esketamine as both IV and Spravato. Spravato is a waste of time and money. After going through the initial 8 week transition, I was in for Spravato almost every other week where I was in for IV once a month to as long as every 6 weeks. The side effects were horrible, headache, exhaustion for a day or 2 and not knowing where I was. This drug was barely vetted by the FDA with only 80 test subjects in their group. IV ketamine has years of use and they know it works, but because there is zero money to be made they will never approve it so our insurance will pay for it”

1 / 10
Captivating · Taken for 6 months to 1 year August 3, 2020

For Depression: “I started in December and put it simply it saved my life. It took about six weeks and I've also been taking Prozac and some supplements which have also helped. for the first time in my life I feel like I can function normally. I would be a poster child for this drug if I could.”

10 / 10
KB · Taken for 1 to 2 years July 16, 2020

For Depression: “Spravto Let’s just say this is when you have tried everything else and you still need help. If you think this is just a way to get high your wrong. Although my one and only bad experience out of 40 treatments was pretty Psychedelic. I just didn’t know where I was. My doctor was nervous. Otherwise this drug has worked very well for me in certain areas. My suicidal thoughts have lessoned by half. Depression down a quarter. This is a new drug so they are still working on it.”

8 / 10
J · Taken for less than 1 month June 6, 2020

For Depression: “On Spravato I felt like I was going to die. It took 4 minutes to kick in. I couldn’t feel my face, couldn’t speak, couldn’t breathe, the room was spinning, music felt far away even though I had headphones in. I heard the ocean. I was sweating/ felt like I was sinking, mind racing, nauseous. I felt like I was strapped to a Ferris wheel that wouldn’t stop spinning/falling really fast. I was crying & sweating, 22 minutes in I had a ringing in my ear. It gave me a headache. I couldn’t hear my music anymore, that scared me. I couldn’t move. I was crying for my mom. It was really scary. I don’t feel 100% back to normal today (appointment was yesterday). I feel lethargic- spacey with no appetite. I feel sad/disappointed that this didn’t work. This was literally the last thing to try treatment wise. I have to go back to doing TMS everyday. Please don’t try this unless it’s your LAST resort.”

1 / 10
Stephanie · Taken for 1 to 6 months May 24, 2020

For Depression: “Details: a medium intranasal dose twice a week in office for a month, followed by a high dose once a week. Not a cure. If you stop, your depression will return. Experience: spray a mist of Spravato into each nostril while at the office. You then need to wait two hours to be monitored for the effects to wear off. For me, the first 20 minutes are unpleasant, like a psychadelic trip that is a bit too strong. Due to COVID-19, I cannot bring anyone with me, so I listen to guided meditations. I have vomited on the higher dose, but an accompanying zofran has helped tremendously. In my bag: water bottle, crackers, hard candy, a book. The nasal spray drips down your throat and tastes terrible. Results: Spravato has helped me tremendously. I am 36, and have had depression since I was 12. I have tried many medications, with only minor results (including TMS). The appointments are unpleasant for me, but they are worth it for the relief. It was about two months before I saw results.”

10 / 10
Ana · Taken for less than 1 month April 10, 2020

For Depression: “I would like to know if anyone else currently being treated with Spravato has had insomnia/flashback/extremely weird and vivid dreams? I have only completed 2 treatments so far and am curious as to how it is affecting others.”

8 / 10
Danchise · Taken for 1 to 6 months February 3, 2020

For Depression: “When I read about Spravato I was so excited. I had failed TMS and multiple oral medications so this new format of spraying something directly into your brain. Initially I had a great amount of disassociation for the first hour, which gradually dissipated. The day of the treatment I felt great, but then it seemed to just go away. While on it I had increased suicidal ideations. I was also hospitalized 2 months later with pneumonia and fluid in my lower left lung. THESE TWO COULD HAVE ABSOLUTELY NO RELATION TO EACH OTHER. But after that I elected to stop taking Spravato. I think it is very promising but it is too new to have a history and I’m done being the guinea pig”

2 / 10
Bruno · Taken for 1 to 6 months January 24, 2020

For Depression: “Really Helped. IV is better, but this bridges the gap”

10 / 10
Baldfun · Taken for 1 to 6 months January 19, 2020

For Depression: “After being on 6 different anti depressants and doing 6 weeks of TMS with no relief from my depression I was prescribed Spravato. I completed 4 weeks of treatments of 84mg 2 times per week, 4 weeks of treatments one times per week and one treatment every other week. I have had no relief from my depression. I feel like the effectiveness of this drug was over hyped. It was expensive and time consuming and very disappointing to have no results.”

1 / 10
AJ January 18, 2020

For Depression: “I did the IV Ketamine for several months and found it very helpful, but it wore off very quickly. My physician has recommended that I start Spravato, as he has sometimes seen its benefits last longer. I have now had 2 treatments with 53 mg. I do not feel dissociative symptoms, like with the IV, but I have significant symptoms of motion sickness. The night of the treatment, I feel exhausted and this is lasting into the following day. With the IV treatment, my symptoms fully resolved the night of treatment. I am trying to determine if these treatments are worth continuing. The side effects are prolonged and there is no certainty that the benefits will last very long.”

4 / 10
Kjo · Taken for less than 1 month January 2, 2020

For Depression: “An exciting experience that lifts you into a different way of looking at many things. Colors and objects appear more enhanced and even strikingly different than usually experienced but quite interesting and most surprisingly more in depth.”

Austinite · Taken for less than 1 month December 30, 2019

For Depression: “Spravato has been miraculous for me. The day after my third treatment (first at 84 mg) I felt the darkness lifting. My depression score went from severe depression to mild mood disturbance. I haven’t felt normal in six years. Tried dozens of meds, and nothing. I’m still not 100%, but so much better. I don’t dread my life anymore. The crushing sadness is gone. I know everyone responds differently, but for me it’s been life-changing.”

8 / 10
Anonymous · Taken for 6 months to 1 year December 27, 2019

For Depression: “Depressed NO MORE.. Thanks Spravato”

10 / 10
SpravatoUserNY · Taken for 1 to 6 months December 6, 2019

For Depression: “Hi, I think people who are taking Spravato should read the wealth of information from maker. I have severe anxiety. It does not assist anxiety. If you have a doctor giving you Spravato for severe anxiety- that’s insane! Spravato is for depression only. Take the dose, relax and you absolutely want to be alone, lights off and listen to music YOU LIKE. Do not sit in a lighted room with the clinician. They will come and check on you. I do not recommend you bring a family member while the medication is working. If you can stand go to the bathroom if you have to. If you can’t stand - ask for help. Having to use the bathroom takes the entire process of reprogramming your brain away. Urination- yes it is more difficult on Spravato. Going #2- Your not suppose to eat food at least 2 hours before taking meds. Is it worth it? Yes!! Does it last forever? No but as I get more and more doses it is working longer and longer. I hope this helps someone else.”

7 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.