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Is Spravato (esketamine) a controlled substance?

Medically reviewed by Drugs.com Last updated on Sep 10, 2019.

Official Answer

by Drugs.com

Yes. Spravato (esketamine) is a Schedule III Controlled Substance in the United States.

Spravato is rapid acting nasal spray used conjunction with an oral antidepressant, for use in adults with treatment-resistant depression. It was approved by the FDA in March 2019.

Spravato contains esketamine, which is the s-enantiomer of ketamine. Ketamine is a mixture of two enantiomers (mirror image molecules). The FDA first approved ketamine (Ketalar) in 1970 for use as a rapid-acting general anesthetic, but in more recent times has become known as a drug of abuse (Special K) due to its hallucinogenic properties.

Both esketamine and ketamine are listed under schedule III of the Controlled Substances Act (CSA).



 

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