Spravato and Suicidal Thoughts: What Users Say

• Dan...
• Taken for 1 to 6 months
• February 3, 2020

For Depression "When I read about Spravato, I was so excited. I had failed TMS and multiple oral medications, so this new format of spraying something directly into your brain. Initially, I had a great amount of dissociation for the first hour, which gradually dissipated. The day of the treatment, I felt great, but then it seemed to just go away. While on it, I had increased suicidal ideations. I was also hospitalized 2 months later with pneumonia and fluid in my lower left lung. THESE TWO COULD HAVE ABSOLUTELY NO RELATION TO EACH OTHER. But after that, I elected to stop taking Spravato. I think it is very promising, but it is too new to have a history, and I’m done being the guinea pig."

• Kay...
• Taken for 1 to 6 months
• November 6, 2022

For Major Depressive Disorder "My major depressive disorder is drug resistant. I used Spravato at a doctor's office 3 times weekly for about 6 weeks. My first 2 weeks were filled with sadness, followed by mad anger (PTSD symptoms) for the following 2 and experienced deeper sadness and suicidal ideation for the last two. We then stopped treatment about a month ago, and I am still struggling with deep sadness. I feel disappointed. I had been so hoping for lasting help. I've begun to lose hope that I'll never again experience life with more delight."

• Des...
• Taken for less than 1 month
• July 4, 2022

For Major Depressive Disorder "Spravato ended up making me have suicidal thoughts, and I think maybe go into a psychosis or something... I took it for a month. Twice in one week, 34 mg, and then the rest ones were 84 mg once a week. You take it like a nasal spray, and it burns a lot. I just couldn’t move and felt drunk, like mucked up, seeing tracers for about 45 minutes maybe. I didn’t like how I couldn’t move. I was completely numb, it helps pain for that time. But when it wore off, I was still numb mentally. I would get angry when it wore off. It just has to be known, it made me worse. They told me it was impossible to feel worse, which is so stupid. I also have PTSD, social anxiety, and generalized. Spravato made me take a lot of steps back. I had worked so hard to the point to where I was, and it tore it all down. Now I am a lot better and building it back up. But I just still don’t feel 100%. I hope I do. It made me aggressive, I wanted to fight people and harm myself. I used to be addicted to self-harming."

• Dan...
• April 4, 2023

For Major Depressive Disorder "I’ve just had my 9th Spravato at 84 mg. I have only today felt the effects on me. It was not a scary ‘trip,’ but it wasn’t nice. I felt distressed and a bit ‘out of it.’ For example, I have chronic lower back pain, I felt the pain but couldn’t feel my legs. I am trying to find the positive side of this in the fact that at least I did feel it. I was really worried that it wasn’t working at all. I now hope number 10 has an effect as well. They are talking about possibly moving me from the Spravato spray to ketamine infusions. So I will update you as soon as I can. At the moment, my mood is still desperately low, and suicidal thoughts are paramount. I hope my next ‘review’ is a more positive one."

• 777...
• October 15, 2019

For Depression "Anybody have increased suicidal thoughts on Spravato?"