Skip to main content

Spravato and Confusion: What Users Say

Confusion: mentioned by 5 users (4.0%)

Based on user experiences from 125 Spravato reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 10.4%
anxiety 8.8%
dizziness 6.4%
bad taste 4.8%
confusion 4.0%
hallucinations 4.0%
headaches 4.0%
suicidal thoughts 4.0%
depersonalization 3.2%
depression 3.2%

Reviews for Spravato

  • ano...
  • Taken for less than 1 month
  • November 26, 2019

For Depression "I had my first experience with Spravato yesterday, and the side effects were just awful. Felt extremely drunk-dissociation, severe nausea and sweating, dizziness, tiredness. Could barely make it home (I got a ride) and get myself into bed to lie there for the rest of the night. The next morning-extremely tired, nauseous. Felt hungover. No effect on my TRD (treatment-resistant depression) after 1 treatment. I will continue as long as I can stand it because I am pretty much out of options. But I am dreading it more than I did with ECT."

3 / 10
Was this helpful?YesNo
62 Report
  • Dan...
  • Taken for 1 to 6 months
  • February 3, 2020

For Depression "When I read about Spravato, I was so excited. I had failed TMS and multiple oral medications, so this new format of spraying something directly into your brain. Initially, I had a great amount of dissociation for the first hour, which gradually dissipated. The day of the treatment, I felt great, but then it seemed to just go away. While on it, I had increased suicidal ideations. I was also hospitalized 2 months later with pneumonia and fluid in my lower left lung. THESE TWO COULD HAVE ABSOLUTELY NO RELATION TO EACH OTHER. But after that, I elected to stop taking Spravato. I think it is very promising, but it is too new to have a history, and I’m done being the guinea pig."

2 / 10
Was this helpful?YesNo
58 Report
  • Dan...
  • April 4, 2023

For Major Depressive Disorder "I’ve just had my 9th Spravato at 84 mg. I have only today felt the effects on me. It was not a scary ‘trip,’ but it wasn’t nice. I felt distressed and a bit ‘out of it.’ For example, I have chronic lower back pain, I felt the pain but couldn’t feel my legs. I am trying to find the positive side of this in the fact that at least I did feel it. I was really worried that it wasn’t working at all. I now hope number 10 has an effect as well. They are talking about possibly moving me from the Spravato spray to ketamine infusions. So I will update you as soon as I can. At the moment, my mood is still desperately low, and suicidal thoughts are paramount. I hope my next ‘review’ is a more positive one."

6 / 10
Was this helpful?YesNo
14 Report

Frequently asked questions

  • Bet...
  • Taken for 6 months to 1 year
  • March 7, 2022

For Depression "I’m happy with my results. It took me until the 4th week to feel substantially better. I’m a few months into a weekly maintenance schedule. I found the treatments somewhat unpleasant initially, but soon grew used to them. My advice: It’s not a miracle cure, so try to temper your expectations—the limited studies have shown that Spravato + a new antidepressant is maybe 30% more effective than a new antidepressant alone. Although the manufacturer contends people might feel better within days, not everyone will. It’s not a psychedelic therapy; any dissociation is a side effect—talk to your doctor about how Spravato works. The intensity of the dissociation is not an indication of how strong a given treatment is. It’s not a treatment for bipolar, anxiety, or PTSD."

9 / 10
Was this helpful?YesNo
11 Report
  • Win...
  • Taken for less than 1 month
  • October 4, 2022

For Major Depressive Disorder "I only tried Spravato once, but it was too bad to continue. A few minutes after the nasal sprays, I had a horrible taste in my mouth, then nausea, then crying, dissociation, sweating, etc. Now I’m back home after a few hours with somewhat of a hangover feeling: headache, still nauseous, and now also a sore throat. I can’t accurately “rate” this drug since it needs to be taken for quite some time to get the results, but the side effects were just too horrible to go on. *Side note: I have also done several ketamine infusions prior to this, with only a bit of nausea once."

3 / 10
Was this helpful?YesNo
10 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.