Clomipramine User Reviews & Ratings

• olc...
• Taken for less than 1 month
• April 29, 2025

For Panic Disorder "I've been using Anafranil for 5 days. 25 mg - so far I've had dry mouth, fatigue, and lack of motivation. After 7 days, I am to increase the dose to 50 mg, and after 2 weeks, 75 mg. So far, I feel less anxious, I sleep better, I have no diarrhea. I hope, as people recommend, that it will help me with social phobia and panic disorder."

• Tom...
• April 2, 2025

For Obsessive Compulsive Disorder "This drug saved my life after a 30-year battle with responsibility OCD. I now am finally the person I was meant to be. OCD robbed me of so much happy time and nearly ruined my marriage. But now I have won thanks to Anafranil. No one knows the torment I have endured, apart from other sufferers of this terrible illness. Give Anafranil a try and good luck, and God bless."

• Gez...
• Taken for 2 to 5 years
• March 31, 2025

For Obsessive Compulsive Disorder "I guess all my life I have had obsessive thoughts, but it was not until 50 that I finally broke down. First of all, I just did not know what was happening to me. I started the SSRI lottery, and my obsessions and major depression were joined by panic attacks, mania, anxiety, massive insomnia, and burning pains all over my body. After 1 year of trying all kinds of stuff and benzos, I was put on clomipramine. I felt awful for a month and massively without hope as I thought that it would be another fail and that I was condemned to a life in bed, no job, no nothing. However, miraculously I started to pull out of it and get my life back. So thanks to the medicine, it created a version 2.0 of me, more relaxed and more confident than my previous life. I am now 55 and living a perfectly normal life. I take 50 mg (2 tablets of 25 mg) and sleep 8 hours a day without a problem. A little bit of dizziness, but only rarely, and a very small amount of urinary retention. It's been a miracle for me!"

• Anonymous
• Taken for 1 to 2 years
• March 13, 2025

For Panic Disorder "Eliminated my panic and anxiety attack. Medication was a lifesaver. Cured my anxiety and panic."

• med...
• Taken for less than 1 month
• March 7, 2025

For Obsessive Compulsive Disorder "I tried it. It is not bad, but for me it did let me sleep. I find it quite hard to sleep."

• Bre...
• Taken for 6 months to 1 year
• February 28, 2025

For Obsessive Compulsive Disorder "Great for OCD when on 150 mg, but had to stop this drug due to the horrible side effects. Constipation so bad I had to go to the hospital, dry mouth, and red skin, plus a weird constant tingling in my feet. Weaning off the medication was surprisingly easy. Recently started on Paxil 40 mg with no side effects. So far, Paxil doesn’t seem as “good,” but the side effects are just not worth it, unfortunately."

• ste...
• Taken for less than 1 month
• February 3, 2025

For Obsessive Compulsive Disorder "Wow. This is the big hitter for OCD suppression. I can finally see my thoughts clearly instead of becoming really analytical and breaking down obtrusive thoughts into small pieces and working myself into a panic. Would recommend."

• Anonymous
• Taken for 1 to 6 months
• January 22, 2025

For Depression "If you have tried other drugs and feel hopeless, don't hesitate. Just start with the minimum dose and then increase it. I came to this drug after about 23 years. I was severely depressed. Antidepressants, other tricyclics, antiepileptics, antipsychotics, all were useless. I hope you live happily."

• Hab...
• Taken for 6 months to 1 year
• January 16, 2025

For Obsessive Compulsive Disorder "I’ve been struggling my whole life and had no relief until my early thirties when my current psychiatrist gave me no option but started taking clomipramine. Currently on 150 mg, and it feels awesome, no major issues with side effects. Highly suggest taking it along with CBD oil drops. Trust me, I’ve tried at least five different antidepressants, antipsychotics, mood stabilizers, and sedatives, among others. When I look back, I feel sorry for myself for not stepping up and asking for those two drugs. Now I’ve got a career, a steady job, and I live by myself. My thoughts, behaviors, everything was compromised until now. I truly believe that it is not psychological but biological. Give it a try, you must be miserable at the moment anyway."

• Chr...
• Taken for 10 years or more
• January 12, 2025

For Depression "I've been taking this drug for over 40 years, and it saved my life. I had a nasty virus in my 20s, which left me with anxiety and depression. After trying and failing to cure myself, I was put on this. After 2 weeks, I felt normal again. I regulate it myself, as I'm always better in the summer. A few years back, the doctor wanted me to try a different SSRI type, and it left me suicidal. So I'm back on Anafranil/clomipramine and back to normal. I currently take 40 mgs."

• Des...
• October 19, 2024

For Depression "I love this medicine. It's noticeably effective. I'm glad I came across this drug."

• Des...
• October 18, 2024

For Depression "Incredibly effective for depression. I really like this medicine. I'm glad I know it exists."

• GMW...
• Taken for 6 months to 1 year
• October 10, 2024

For Obsessive Compulsive Disorder "Clomipramine is very good for OCD, but one side effect that I have been facing is itching of arms, legs, and stomach. This itching becomes severe at night and interferes with my sleep. I apply an ice pack on the area that itches, then I apply Luliknaz cream on the areas that itch. The itching becomes lesser, but does not vanish soon."

• wen...
• Taken for 6 months to 1 year
• October 7, 2024

For Depression "I have been depressed nearly 33 years. I've tried 24 different medications, Spravato, and TMS. My psychiatrist suggested starting this. I'll be honest, I did not have high hopes about it at all, but after one week, I started feeling better. I've been on it now for approximately 6 months, and I've got my motivation back, the dark cloud that followed me is gone. I do have some side effects such as constipation and talking in my sleep, but I can deal with those. I know everyone is different, but my hope is that if it doesn't work, to not give up. There's a medication out there for you, you just have to keep looking."

• ove...
• Taken for less than 1 month
• September 16, 2024

For Depression "This has to be the best medicine. I replaced it with my depression bad. As I stopped taking it without Dr. consent, I honestly was very bad. Went twice to the hospital. After being put on these meds for 5 weeks, I got my life back. Never been this happy. I'm really overwhelmed writing this review. No side effects, only constipation, but settled quick. My depression is gone and the bad anxiety, for which I was taking Ativan up to 3 times a day, also gone. I'm alive again, going for morning walks every day, as I found it helped me a lot. What can I say? The best med ever. I honestly thought nothing was gonna work on my depression and anxiety. Here I am writing a review on it. 10 out of 10. Please give it a try."

• Bre...
• Taken for 1 to 6 months
• September 5, 2024

For Obsessive Compulsive Disorder "Started on clomipramine after being on SSRIs for 20 years. Weaned off Lexapro 40 mg and started on 25 mg of clomipramine. The first month has been rough, no sleep, extreme constipation, dry mouth, and anxiety, but 5 weeks in it’s getting easier and helping my OCD more than anything ever has. It’s also helped with my depression and irritability. I am now on 100 mg 5 weeks in, and things are looking better. Only side effects now are dry mouth and constipation."

• Unk...
• Taken for 6 months to 1 year
• August 13, 2024

For Panic Disorder "It's a wonderful med, but fully eliminating panic takes at least 6-8 months. It's not a benzo, it's going to go down day by day. Be patient. Take some benzos with it and a higher dose if possible. I'm taking 250 mg. Hope this helps someone."

• clo...
• Taken for less than 1 month
• August 4, 2024

For Depression "Been on it for 10 days today along with mitrazipine 30 mg, hoping this will work for me soon as I suffer from depression and anxiety, the only side effect I got was reduced appetite and anxiety, will it get better anyone please need some advice, support, thanks too early to rate it now, hoping it will work soon."

• Bri...
• Taken for 1 to 2 years
• July 25, 2024

For Obsessive Compulsive Disorder "Saved my life. My OCD has always caused vulgar and aggressive intrusive thoughts, they became so potent that I nearly checked myself into an early grave. The only side effect I had when starting was that it made my sleep a bit lighter, so I woke easier. I haven’t known silence like this from my intrusive thoughts in all my life. I can breathe again."

• Pre...
• Taken for 6 months to 1 year
• July 19, 2024

For Depression "I've been taking SSRIs since I was 18 for MDD. All of them: Paroxetine, fluoxetine, sertraline, duloxetine, citalopram, escitalopram, and Wellbutrin and so on. Nothing worked. I'm under therapy for 5 years, nothing happened. I told my psychiatrist I'm willing to go under ECT, because I have had enough, I don't want to die, and she brought up clomipramine. In my country, it is extremely rarely prescribed, only for absolutely treatment-resistant major depression. She prescribed it to me. We started with 25mg, now we are at 150mg, and man... It changed my life. I could leave alprazolam, I sleep like a baby, and I feel like a normal human being. Taking a shower is no longer a task, it's a joy. It's making wonders. She saved me from ECT, and it works. I wish I knew about this medicine before I begged for ECT. Give it a try, give it 6 months, you will feel amazing. The only side effect is no libido, but I could not care less, I just want to live. Props to my doc."

• Sma...
• Taken for 1 to 2 years
• June 20, 2024

For Obsessive Compulsive Disorder "It’s effective in OCD, but it can cause impulsivity and sexual dysfunction. It caused weight loss. Lack of reasoning became an issue when it stopped intrusive thoughts. I am able to manage without it for over 25 years now. You need to talk more, go out more. Relaxation can also help."

• tt8...
• Taken for 1 to 6 months
• June 17, 2024

"I have a sound sensitivity disorder (hyperacusis). A pharmacist recommended that I give clomipramine a try. I increased the dose slowly to 200 mg. It has been working! Most of my ear pain is gone, and I can hear loud sounds without getting worse hyperacusis. I still have some degree of sound sensitivity, but it has improved quite a bit. I am going to continue taking this drug for at least six months. I don't know if there is any research on hyperacusis and clomipramine yet, so it is definitely an off-label use. I know I am not the only one who has gotten improvements in hyperacusis from this drug... if you have hyperacusis, I urge you to give this a try and see if it works for you also."

• uue...
• Taken for 1 to 2 years
• June 1, 2024

For Obsessive Compulsive Disorder "Clomipramine has been a game-changer in my battle against OCD. Its effectiveness in reducing obsessions and compulsions has truly transformed my life. I've experienced significant relief from anxiety and regained control over my daily activities. Clomipramine has been a beacon of hope on my journey to overcoming OCD, and I highly recommend it to others struggling with this disorder."

• Pai...
• Taken for 5 to 10 years
• May 1, 2024

"Clomipramine, like most if not all tricyclics, can be a useful adjunct for chronic pain conditions. At least that's been my own experience, and I've heard some others say the same. It can take a week or two to really kick in, but some people notice relief sooner. Side effects (again my own experience) can be quite heavy with the particular tricyclic, even worse than desipramine which is pretty uncomfortable. Sweating, yawning, extreme tiredness, and depression are common in the first week, then this all lifts and sleep patterns return to normal. I always take very low doses, only 12.5 - 25 mg per night."

• Anonymous
• Taken for 10 years or more
• April 13, 2024

For Obsessive Compulsive Disorder "This medicine has helped me more than words can say. It has completely changed my life. My OCD is so much better."