Clomipramine User Reviews & Ratings (Page 4)

• ePo...
• Taken for 1 to 6 months
• September 8, 2021

For Irritable Bowel Syndrome "I have had IBS-D for 4 years, and it was gradually becoming worse and worse. Because of depression and OCD, my doctor put me on Anafranil 112.5 mg. In spite of not helping my depression and OCD, it immensely helped my IBS-D. On Anafranil, I rarely have soft stools. And when I do, it is because I didn't follow the low FODMAP diet. My only complaint is that it caused me sexual dysfunction at doses higher than 37.5 mg. It makes sense, as Anafranil is the antidepressant that causes the most sexual dysfunction. If you're searching for a med that can help your anxiety and IBS and doesn't cause as much sexual dysfunction, I would search for amitriptyline or nortriptyline."

• tho...
• Taken for 1 to 2 years
• September 8, 2021

For Obsessive Compulsive Disorder "Just Godsend! 150 mg, no side effects, OCD destroyed."

• Leo...
• Taken for 6 months to 1 year
• September 6, 2021

For Obsessive Compulsive Disorder "I was skeptical about clomipramine, but this totally changed my life. Built up slowly from 10 mg to 100 mg under the supervision of a GP who knew what they were doing, because I experienced hardly any nasty side effects! I believe that my OCD exists in ‘layers’ and that clomipramine peeled back several of these layers. All of my rituals - which would take hours out of every day - (for 7+ years) all kind of melted away once I got to about 50 mg. Crazy. I still have OCD now, but mostly ‘Pure OCD’ in that my visible rituals have gone. I still experience a lot of doubt and anxiety, the OCD is still there, but the improvement has been more than I could ever have expected. Took several months to really kick in, and had to be this high of a dose. I still want to come off meds one day, but right now, this helps me to function and engage better with therapy."

• Ann...
• Taken for 1 to 6 months
• August 11, 2021

For Obsessive Compulsive Disorder "I take 175 mg of clomipramine for OCD, dermatillomania, and treatment-resistant depression for over 6 years. After about 2 months, my dermatillomania has almost vanished, and my intrusive thoughts diminished greatly. The only downside is the dry mouth, but chewing gum (sugar-free) helps a lot. I've tried SSRIs, and they just were sedative. The side effects of clomipramine seem like a small price to pay (at least the side effects I have felt thus far) for relief from chronic OCD and depression."

• JDa...
• Taken for 1 to 6 months
• July 29, 2021

Clomipramine for Obsessive Compulsive Disorder "I’ve taken Anafranil for a month now because I had been struggling with anxiety with an OCD element as well. I’m on 150 mg right now. This medication is definitely helping. I take Prozac 20 mg as well, and I think they work better together. For me, it’s helped to stop worrying and thinking about things that don’t matter. Also, I’ve had random intrusive thoughts of uncomfortable words popping into my head. It’s made me realize how ridiculous it really is and that it’s really a bad serotonin imbalance. My mood has improved as well, so I think this drug should be used more because it’s a potent drug. It’s gonna hit the anxiety/OCD hard, whereas I tried Zoloft, Viibryd, Pristiq, etc., and they alone usually aren’t enough. You gotta be on Anafranil plus Prozac/Luvox/Paxil or some other SSRI. I’m also on Rexulti, which basically boosts the two primary medications. No side effects so far either. Hope this is helpful."

• Ala...
• Taken for 1 to 6 months
• July 21, 2021

For Obsessive Compulsive Disorder "Clomipramine gave me back my quality of life and ability to function. My OCD no longer controls me. Obsessive thoughts are less frequent, and normally when they do happen, I’m able to shrug them off and they don’t torment me. Only side effect is dry mouth and muscle twitches for a few days when increasing dose."

• GSa...
• Taken for 2 to 5 years
• July 7, 2021

For Depression "This drug was a breakthrough drug for me. I’d tried everything from Prozac to ketamine with partial success. Clomipramine leveled out my problems getting to sleep and staying asleep. Ideation was just a fact of life for me until I started this drug. Of course, counseling, exercise, diet, and stress management are part of any worthwhile treatment plan for depression, and those haven’t changed. It’s become easier to make and keep good habits. Orgasms take a bit longer, but what antidepressant doesn’t have that effect in men?"

• M13...
• Taken for 6 months to 1 year
• June 16, 2021

For Obsessive Compulsive Disorder "I started this medicine last year. It does help with intrusive thoughts, but for me, it had too many side effects. Started at 25 mg, and it took me forever to get to 50 mg. At 50 mg, the tremors were bad, high heart rate, restless, insomnia, night sweats, constipation, urgency to urinate, feeling bloated. So I figured out why the constipation and bloating, it is because this medicine contains lactose. Currently tapering down. And terrible vivid nightmares."

• eli...
• Taken for 1 to 2 years
• June 6, 2021

For Obsessive Compulsive Disorder "This drug changed my life. After having OCD since early childhood, and it getting increasingly debilitating through adolescence, I was finally put on this after trialing many SSRIs and Effexor. I feel like it's literally impossible for me to feel anxiety on clomipramine, and my depression has disappeared too. I've been on it around 18 months now. The side effects at the start were terrible, not going to sugarcoat it. I fainted so much, couldn't poop for so long (got hospitalized because it got that bad), but magnesium citrate helps that. Give it time to work. There is a reason this medication is so well-rated once it's in your system."

• Mle...
• Taken for 2 to 5 years
• April 28, 2021

For Obsessive Compulsive Disorder "This stuff literally saved my life. After failing probably 10 drugs and therapy for extreme OCD, clomipramine (75 mg/day) changed my life like nothing else. We have to be very careful because I'm also epileptic, and clomipramine particularly severely lowers the seizure threshold, but I wouldn't stop it for anything. It gave me my life and my sanity back."

• Rai...
• Taken for 6 months to 1 year
• April 27, 2021

For Obsessive Compulsive Disorder "I had SSRIs work for 20 years, for some reason they stopped. I had a relapse with OCD and was having 70 obsessions a day, some compulsions too. I went on clomipramine and they started to slowly decrease. It started with one chronic obsession going and slowly got rid of them all, well 90% of them. It took 3 plus months to really feel it. I went up very slowly as I'm drug-sensitive and had the odd lapse where I was so frightened they weren't working, but it just got better and better. Now I'm functioning. I was so chronic, I was going to give up if it didn't work. Definitely with this drug, give it up to 6 months before deciding it's not working. But I believe the person reading this will definitely find peace from an awful debilitating illness called OCD. Try it. Give it a good go. It is rough going at first, it can feel worse, but it will get better. Hold on."

• Typ...
• Taken for less than 1 month
• April 10, 2021

For Obsessive Compulsive Disorder "I started this medicine 2 weeks ago. I had been majorly depressed for about 3 years and OCD longer. It started off okay, and I felt better almost a day in. This continued as I increased the dosage. I slept better, I was less stressed, happier, and could relax in a chair, which was almost impossible when depressed. Intrusive thoughts appeared every so often, but not as severe. It was life-changing until day 13, after taking 100 mg a day for the past 3 days. I had dissociation, fast heartbeat, panic, anxiety, paranoia, hallucinations, shaking, and everything turned dark. I smelled a pungent varnish bark smell. I had a trip to A&E for 2 nights. The medication has been stopped, and I am left in a dark, strange, scary place with strange perceptions. I am bedridden and afraid to go anywhere. I hope I at least am able to recover as I was on them for less than 2 weeks, and just hoping I get something to come off the drug with. It is seriously brutal - it is like winning a football match then suddenly being dumped in a graveyard with screaming voices and strangers."

• And...
• Taken for 1 to 6 months
• April 9, 2021

For Obsessive Compulsive Disorder "Clomipramine has been a lifesaver. It has taken away nearly 90% of intrusive thoughts. Over the next week, the doctors will increase the dose to 150 mg, and I believe it will help a lot. The first 4 weeks were tough on the drug, and I suggest anyone trying the drug to hang on and stick in there. Side effects are it takes longer to orgasm and dry mouth from time to time. Overall, a thumbs up from me."

• BLR...
• Taken for 6 months to 1 year
• March 23, 2021

For Depression "I am taking clomipramine for postnatal OCD, anxiety, and depression. The only reason I haven’t given this drug 10/10 is because it has taken 6 months to fully feel its effects. I remember reading these reviews at 2/3 months and thinking that it just wasn’t working for me. Side effects: dry mouth, tremor, facial flushing, immediate headache if consuming alcohol. These have mostly reduced, but I still can’t really drink alcohol at all. I believe a combination of this medication, therapy (ERP works best for the OCD!), meditation, mindfulness, and time have helped me get to this stage. It’s like a new, better level of the drug opens up after 3 months and again after 5 months, that was my experience anyway. If you’re in despair reading this, I would suggest speaking to your doctor about clomipramine, it’s an older tricyclic but has worked much better for me than other SSRIs. Good luck!"

• Sam...
• Taken for 6 months to 1 year
• March 19, 2021

Clomipramine for Obsessive Compulsive Disorder "Anafranil helped my OCD symptoms a little bit and helped me sleep at night. However, as my doctor increased my dosage, I started gaining weight, having horrible acne, and severe constipation. It also made me crave junk food like some kind of addict. I was on Anafranil for about 10 months and gained 40 lbs. I haven't taken Anafranil in about 8 months. I've lost the 40 lbs. I didn't have to go on a diet or anything, as soon as I was off the drug, my appetite went back to normal. However, 8 months later, and my colon is still not healthy. I still have major issues with constipation and bloating. My doctor had me try Zyliss, a drug for IBS, and it helps a little. I feel like Anafranil may have ruined my gut. I have a hard time leaving the house because I am so uncomfortable in my gut. I wish I had never taken this drug. I was much better off before."

• jde...
• Taken for 1 to 6 months
• March 7, 2021

For Obsessive Compulsive Disorder "I am on 150 mg, and it has been extremely helpful for my OCD and depression. There are side effects such as dry mouth, difficulty urinating, and it takes longer to orgasm, but overall, it has been very helpful."

• Ave...
• March 5, 2021

For Obsessive Compulsive Disorder "Started at 25 mg. A week later, I was taking 50 mg. Mouth was dry, but I could deal with that. Went up to 75 mg. I was having difficulty urinating. Okay, I can deal with that as long as that's the worst. Went up to 100 mg. Could not urinate at all. Went to the ER and was catheterized - I had to be catheterized due to the amount of urine in my bladder. This was Saturday. The doctor looked up this medication and found this happens to 6% of patients - which is considered a fairly high number regarding side effects. The doctor said to go to a urologist on Monday. Went to a very good urologist with excellent staff. They took out the catheter, and I was able to urinate. Went home and urinated 2 times. By 2:00, I wasn't able to go at all. Back to the urologist and got catheterized again. The amount I had in my bladder was 450 - apparently, that is quite a lot. The doctor said this medication has 5 half-lives, which equals 160 hours!!! Went home with the catheter. Today (Thursday), the catheter was removed, and it's 10:00 pm and all is good. *Knocks on wood*"

• Geg...
• Taken for 6 months to 1 year
• March 3, 2021

Clomipramine for Depression "I had tried escitalopram (Scippa) and vortioxetine (Trintellix) before, practically both were ineffective. Anafranil has been a miracle for me, within a month, it reduced my severe suffering very effectively and made me much better for 90% of my time. And it was reached quickly with a very small dosage: 20 mg a day. Minor side effects occurred during the first couple of weeks, the most unpleasant was the dry mouth and reduced libido, but it bounced back within weeks."

• z-d...
• Taken for 2 to 5 years
• March 2, 2021

For Obsessive Compulsive Disorder "Makes my mouth dry and makes me sweat more than normal. Nevertheless, this med has helped to quiet my head to a manageable level to function."

• Sve...
• Taken for 1 to 6 months
• February 13, 2021

For Obsessive Compulsive Disorder "After 20 failed medication trials for OCD, I feel in control again. I wouldn't be alive without clomipramine."

• Fli...
• Taken for 6 months to 1 year
• February 11, 2021

For Obsessive Compulsive Disorder "1 year of being off of this drug and I’m still going through withdrawal. This pill may help your OCD, but it will completely screw up your body in other ways. It messed up all of my hormones and gave me the most painful hot flashes you could ever have to the point where it feels like your whole body is on fire. 14 months of being off of it and I still get at least 20 of these hot flashes every single day. On top of that, I was shaking so much while being on this drug you would’ve thought I had Parkinson’s disease. STAY AWAY at all costs, the drug will screw up your life."

• pip...
• February 5, 2021

For Obsessive Compulsive Disorder "The doctor prescribed this for intrusive thoughts and 'pure-O' OCD. The first night on these clomipramine 25 mg pills, I woke in sleep paralysis, and for about a week, had voices telling me to end my life. I had never had voices before, or even depression really. My GP told me to hang in there. But two weeks in, I am no longer hearing the voices or having the thoughts. I no longer feel dull. My symptoms are greatly reduced, and although I still have intrusive thoughts, I move on quickly. My partner says I am very noticeably different. Other side effects I have experienced include: shaky legs in the morning (dissipates quickly), urinary hesitancy, takes longer to reach orgasm but I get there (F, 32), and reduced sex drive, as well as waking like clockwork in the night at between 2 a.m. and 4 a.m. to go to the toilet, but I get back to sleep. A weighted blanket has helped with the sleep issues. Hang in there, folks!"

• Sam...
• Taken for 2 to 5 years
• February 1, 2021

For Depression "Awesome drug! After trying almost all SSRIs with no improvement at all, then the combination of mixing Anafranil and lithium (I'm not bipolar) worked wonders for my depression. Have been on it for a couple of years now and still great. However, sadly did not notice its full effects until probably 6 months. Felt pretty yuk for the first 6 weeks, but then slowly got better, and about 12 months felt great. When nothing else worked, it pretty much saved my life!"

• Hop...
• January 28, 2021

Clomipramine for Obsessive Compulsive Disorder "I had anxiety and intrusive obsessive thoughts so bad that I had insomnia for 3 years. I was an absolute mess, lost 50 lbs, and could barely function. I ended up hospitalized for a week and put on Anafranil 50mg at night. It took about two weeks, but I started to see a light at the end of a very dark tunnel! I had already tried almost everything on the market, and Anafranil finally helped! Today marks 7 years that I have been on this medication. I feel great, and it saved my life!"

• pau...
• Taken for 1 to 6 months
• January 23, 2021

For Panic Disorder "I'm diagnosed with GAD, panic disorder, and OCD. I've been on 150 mg of clomipramine for a week, although I started this medication on a low dose in mid-November. So far, my panic is completely gone, and OCD is mild, but I still have problems with anxiety. Is it typical to have anxiety still at this stage in treatment?"