Skip to main content

User Reviews for Clomipramine

Also known as: Anafranil

Clomipramine has an average rating of 7.8 out of 10 from a total of 238 ratings on Drugs.com. 74% of reviewers reported a positive effect, while 14% reported a negative effect.

Condition Avg. Rating Reviews Compare
Obsessive Compulsive Disorder  
7.8
157 reviews 11 medications
Depression  
7.2
38 reviews 78 medications
Panic Disorder  
8.5
38 reviews 19 medications
Irritable Bowel Syndrome  
9.0
3 reviews 137 medications
Premature Ejaculation  
8.0
1 reviews 3 medications
Trichotillomania  Off-label
9.0
1 reviews 3 medications
Summary of Clomipramine reviews 7.8 238 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Clomipramine

Opt November 27, 2019

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “The best medication so far for OCD is anafranil. It’s completely cured my OCD. Remember OCD is just a medical problem due to unbalanced chemicals in you brain. It’s not you, it’s your brain sending you false messages. Don’t believe the obsessive thoughts, they may feel real but they are fake !”

10 / 10
Was this helpful?YesNo
Hope January 28, 2021

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “I had anxiety and intrusive obsessive thoughts so bad that I had insomnia for 3 years. I was an absolute mess lost 50lbs and could barley function. I ended up hospitalized for a week and put on Anafranil 50mg at night. It took about two weeks but I started to see a light at the end of a very dark tunnel! I had already tried almost everything on the market and Anafranil finally helped! Today is 7 years now that I have been on this medication. I feel great and it saved my life!!”

10 / 10
Was this helpful?YesNo
blessed · Taken for 6 months to 1 year September 1, 2020

For Obsessive Compulsive Disorder: “I'll keep it short, I suffered from severe OCD/Unwanted thoughts. I tried many different meds and just when I was starting to think nothing was going to help the Lord directed me to Clomipramine. This is the only med that has tamed my OCD/Unwanted thoughts. If you suffer from this debilitating disorder please know you're not alone. I don't think I'll ever be 100% cured but my life is so much better now!!!.”

10 / 10
Was this helpful?YesNo
Vicki I won May 5, 2014

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “I have suffered resistant depression/anxiety on and off for 30 years and now I have obsessive compulsive disorder and intrusive thoughts. I started on Anafranil 15 days ago and my OCD/ intrusive thoughts have almost gone I'm on only 100 mg per day and I'm starting to get my life back and the medicines haven't reached their full effect yet, so at this early stage I'm happy to recommend this medication and I hope this helps anyone that reads this, thank you.”

9 / 10
Was this helpful?YesNo
Shannonld January 17, 2015

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “I take this medication for obsessive compulsive disorder and anxiety. This medication has been the saving grace of my life! The only side effects I have experienced are insomnia when I first started it or up a dose, but it goes away within a few days. And dry mouth. But I feel so much better freed of my obsessional thoughts I don't care! I take 150 mg a day and have been on it 5 years. No other medicine has ever been so effective for this long, and believe me I have taken everything you can name!”

9 / 10
Was this helpful?YesNo
medtester · Taken for 1 to 6 months September 28, 2018

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “If you're compulsively looking for evidence for why or why you shouldn't take this medication, stop right now and leave this website! Seriously. Been there many times. Anafranil is a promising drug for the majority of people with OCD and it's worth a shot. I gave it a solid 10 weeks and decided it wasn't the med for me (too many side effects such as fatigue etc and did not feel like myself on it). Feeling a little better w/o it so far (knock on wood), but that doesn't mean it won't work for you. The only way is to know is to try it, and it won't hurt you. Listen to your doctors, but always listen to your body first. If something feels off, don't ignore it. Your doctors want the best for you, but only you can truly know what's working and what isn't. Now, that said, take a leap of faith and stop researching. My personal experience with this drug should mean nothing to you.”

5 / 10
Was this helpful?YesNo
Dev India · Taken for 6 months to 1 year February 13, 2020

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “Clomipramine is the best medication for OCD. I have tried paroxetine, fluoxetine etc but none of them works as much as the clomipramine works. I took it high dosages 75mg per day..now my OCD has gone. It would be also very helpful if you consult with a therapist..my doctors give me sleeping medicine first those doctors are fraud !!!!According to my experience just take the dosage regularly at a certain amount, you will be cured quickly! Good Luck ”

10 / 10
Was this helpful?YesNo

Frequently asked questions

Rainbowbunny80 · Taken for 6 months to 1 year April 27, 2021

For Obsessive Compulsive Disorder: “I had SSRI's work for 20 years, for some reason they stopped. I had a relapse with OCD and was having 70 obsessions a day some compulsions too. I went on clomipramine and they started to slowly decrease. It started with one chronic obsession going and slowly got rid of them all, well 90% of them. It took 3 plus months to really feel it. I went up very slowly as I'm drug sensitive and had the odd lapse where I was so frightened they weren't working but it just got better and better, now I'm functioning. I was so chronic I was going to give up if it didn't work. Definitely with this drug give it up to 6 months before deciding its not working. But I believe the person reading this will definitely find peace from an awful debilitating illness called OCD. Try it. Give it a good go. It is rough going at first it can feel worse but it will get better. Hold on.”

10 / 10
Was this helpful?YesNo
Mlenny · Taken for 2 to 5 years April 28, 2021

For Obsessive Compulsive Disorder: “This stuff literally saved my life. After failing probably 10 drugs and therapy for extreme OCD, clomipramine (75 mg/day) changed my life like nothing else. We have to be very careful because I'm also epileptic and clomipramine particularly severely lowers the seizure threshold, but I wouldn't stop it for anything. It gave me my life and my sanity back.”

10 / 10
Was this helpful?YesNo
Redgraves · Taken for 2 to 5 years September 29, 2018

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “Anafranil has completely cured me of my OCD. I suffered from terrible intrusive thoughts since I was a child, however, I was not correctly diagnosed until adulthood. I have been on 6 25mg tablets a day and it has completely changed my life for the better. Before Anafranil, I was fearful to leave my house because I was scared of having awful thoughts about the people I loved. I have taken Anafranil for three years and I am so well I forget I have OCD. I can think of the thoughts that terrified me so much before and not feel anything. I can acknowledge that they are irrational thoughts and move on. I have had minimal side effects and in fact lost 45kgs while on the tablets (I was previously on Lexapro, which added 35kg). Different medication affects people differently but I can honestly say that I am finally living the life I always wanted to live and it’s all because of Anafranil.”

10 / 10
Was this helpful?YesNo
hapi February 9, 2014

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “I have suffered from obsessive thoughts for 26 years. I have tried different medications over the years. I was on Paxil for 10 years but I never ever felt totally well and I slowly stopped taking it and became very ill. I started taking clomipramine again seven years ago. Again it saved my life and I have been able to have a successful career. I take 250 mg a day. I hate the side effect of weight gain but I will never sacrifice my mental health to lose weight.”

9 / 10
Was this helpful?YesNo
Royjones · Taken for 1 to 2 years June 3, 2014

Anafranil (clomipramine) for Panic Disorder: “Before taking Anafranil I had severe panic attacks and de-realization. Xanax was the only medicine that could help me but only temporarily at high doses. After unsuccessful experiences with other antidepressants which made my anxiety and mood much worse, I was ready to give up pharmaceuticals until I gave Anafranil a shot. I don't preach antidepressants or antianxiety medicines because I don't like them myself, but Anafranil seemed to be the only medicine that virtually eliminated my panic attacks without making me feel 'numb' and 'lifeless'. If you have panic disorder or depression like I do and have had no luck with SSRI's or SNRI's, I urge you to at least try Anafranil.”

10 / 10
Was this helpful?YesNo
kellymcnamara1994 · Taken for 6 months to 1 year June 28, 2019

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “Anafranil is AMAZING for OCD. I’ve tried Zoloft, Prozac and Luvox— but they all made me hypomanic because I have bipolar tendencies. Anafranil, however, has not done that, but rather almost cured me of my OCD (in conjunction with CBT)! I have intrusive thoughts maybe 2x a day or less! Before that they were constant (and so were the compulsions). OCD was ruining my life for 10 years and now I’m 24 and I’m feeling great :) I’m on other meds for depression and anxiety and ADD.”

10 / 10
Was this helpful?YesNo
Mossy · Taken for 6 months to 1 year January 22, 2020

For Obsessive Compulsive Disorder: “The only drug to make a significant difference for me. Has approximately halved my depression, anxiety and OCD. The main side effect is dry mouth. I can actually enjoy life now after twenty years of misery.”

10 / 10
Was this helpful?YesNo
Anonymous December 16, 2012

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “This has been a miracle for me. I suffer from extreme OCD that had left me at times in a state of paralysis and constant fear. This medicine gave me back my life. It will not get rid of all of the OCD for you, but it will make it 90 percent manageable. The Dr who gave it to me was old school. None of the SSRIs worked for me. They were like sugar tablets. This one does. Highly recommend you speak to your physician about it as an option.”

10 / 10
Was this helpful?YesNo
Maciain · Taken for 10 years or more March 7, 2013

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “I have used Anafranil on and off for 30 years. Each time it has worked superbly. I stop and then start again about 2 years later, for a period of about 4-6 months. Presently taking 200 mg along with Beta Blockers - the best experience ever: I am happier, more confident and less anxious than ever in my life. Anafranil side effects are sometimes bad: loss of appetite, sexual dysfunction and blurred vision tend to him me badly. Also can take 2-3 months before they really work. But worth the wait, even though it feels for a while as though it makes you feel worse. Outstanding medicine - a life saver!!”

10 / 10
Was this helpful?YesNo
Karahc.lanas August 17, 2020

For Obsessive Compulsive Disorder: “I have tried all SSRIs for my OCD but they made my condition worse and caused me suicidal thoughts, aggression and depression. Taking those pills for several months (3 to 4 months on each SSRIs) I had to quit them because I did several suicide attempts. Then I met with a doctor after years of struggling who gave me clomipramine! It stopped my suicidal thoughts and reduced my OCD by 90%. Now I have very less obsessions which are very easy to handle. They don't effect me. I started with very low dose and raised to 50mg within 3 weeks. Then I noticed a first small difference. After that I slowly increased my dose to 150mg/day in week 5 and after week 7 (on 150mg/day), it reduced my symptoms by 90%. I am 21 years old guy and my weight is 50kg. Loss of libido, dry mouth, little constipation and mild urinary retention can be a problem for you also but this medicine is worth it, some of the side effects will go over time. It is an old doesn't mean it won't work. This medicine is WORTH IT!!!”

10 / 10
Was this helpful?YesNo
mciain3 · Taken for 10 years or more January 18, 2014

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “Anafranil has always worked superbly for my obsessive compulsive disorder and I have used this medicine intermittently for 30 years. My mistake has always been to completely stop when I feel well - it always comes back. Although an amazing medicine, the downside is that it takes about 8 weeks for the medicine to work and before that I usually feel worse. And the side effects can be a challenge.”

10 / 10
Was this helpful?YesNo
alon22 · Taken for 2 to 5 years October 6, 2013

Anafranil (clomipramine) for Depression: “After 6 years with very strong depression that nothing helps, this medicine saved my life. It takes more then a month to kick in and it continues to grow for full year but after you use it you fill strong and don't think about depression anymore. If you have resistant depression you must try this. It's a totally different class than the rest. I also tried all the natural 5HTP, St. John's Wort and the rest and nothing helped.”

10 / 10
Was this helpful?YesNo
cbtodacb · Taken for 5 to 10 years April 5, 2019

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “This medication was a life-saver for me after years and years of very, very horrible social phobia and terrible panic attacks (lasting hours) in relation to having committed the 'unforgivable sin' (something Jesus Christ warned of committing). My social phobia had begun when I was 15 years old and nothing had helped up until starting Anafranil at 23 years old. Had tried several SSRI's with no help i.e. Lexapro at 60mg daily for years. Anafranil (at a high dose, 12 x 25mg tablets daily) has completely taken my social phobia away as well as my 'unforgivable sin' obsessions. Has been effective for 5 years and is still very effective. Gave me my life back. I use in conjunction with 4mg of Clonazepam and 75mg of Lamitrogine daily.”

10 / 10
Was this helpful?YesNo
Abigail · Taken for 1 to 6 months October 20, 2020

For Obsessive Compulsive Disorder: “I started clomipramine due to a sudden rise in panic attacks and severe OCD. (which was super strange because I have only had a couple panic attacks my entire life) My doctor said this might help my symptoms and I could not be any happier. It has taken away my OCD symptoms about 90%. This is insane. I can't believe I am even typing this. I have had severe, AWFUL, OCD since my childhood and now all of my intrusive thoughts are gone. If I do have them they are fleeting and aren't debilitating like they used to be. At the beginning I had some side effects like extreme dizziness and lack of appetite- but now I feel better and they are lessening. I am confident that this medication saved my life.”

10 / 10
Was this helpful?YesNo
dandalion January 19, 2013

Anafranil (clomipramine) for Panic Disorder: “Have been on Anafranil for 5 weeks now. Prior to starting this medication I tried Lexapro (horrible panic attacks no sleep), Zoloft (made me depressed, worsened anxiety), Cymbalta (dreamlike state, made me totally dysfunctional), dothiepin (slightly alleviated anxiety but not much). I have only taken Anafranil for 5 weeks and it has already cured me of chronic anxiety, panic attacks. Took 4 weeks to really start working but turned out to be a surprisingly effective medicine. I feel great for the first time in years and am starting to get my life back. It has also helped my agoraphobia a great deal, magical stuff.”

9 / 10
Was this helpful?YesNo
Don't Give Up · Taken for 2 to 5 years July 21, 2020

For Panic Disorder: “This medicine clomipramine saved my life from panic disorder. It took me six long years to find this medicine. I used to read all the reviews on this site hoping and dreaming I would one day have relief like so many on here. In fact some days it was my only way of keeping hope. This drug took 6-8 long months to take affect for me. It was slow progress out of hell, but everyday was better than the one before. Like the sun coming up you don't really notice it getting light out. Things that were impossible became possible. My thoughts were quieted and my mind could think about other things beside depression and anxiety. I have been on the drug for 6 years now. My depression and anxiety are gone. Like all gone! not diminished or tolerable but gone. My side effects are increased sweating and loose bowels. I am impacted by them but I would take the trade everyday and twice on Sunday : ) .”

10 / 10
Was this helpful?YesNo
kitkaplan April 25, 2018

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “I’ve been suicidal daily for 37 years. Four inpatient visits, two outpatient, 40 yrs of therapy and 30+ ineffective, neurotoxic meds, all past poop-out, 12+ at a time. At 63, dry mouth has destroyed my teeth and ALL need to be pulled. I have terrifying conscious blackouts up to 24 hrs and no short term memory. For decades I searched for every synonym for uncontrollable thoughts and talking, but nothing fit. Until I heard an OCD trait called ”Memory Hoarding.” Hoard means to protect, not collect, thoughts, feelings and experiences I fear losing. I tell someone a ”story” about these. Out loud and alone, from when I wake until I sleep. I retell it to embellish, then again to shorten. I do it in my head when I'm talking to people so I feel disconnected. I started 25mg of Anafranil, the highest rated drug I know, 3 weeks ago. In one week, I stopped feeling suicidal. No panic attacks or rage. I still tell stories, but not out loud, I sometimes can stop a little. Miraculous!”

10 / 10
Was this helpful?YesNo
MelissaDutfield · Taken for 1 to 6 months January 31, 2014

Anafranil (clomipramine) for Obsessive Compulsive Disorder: “I started taking this medication 2 months ago, starting on 25mg but was too high as the side effects were bad for me so I started on 10mg slowly to 20mg and I think it has made a big difference. I am doing CBT too but the anxiety has decreased significantly. I suffer from intrusive thoughts and this helps it become more manageable and I feel that I'm living again!”

8 / 10
Was this helpful?YesNo

This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.