Cenobamate User Reviews & Ratings (Page 2)

• kay...
• Taken for 1 to 2 years
• July 11, 2025

For Seizures "I think cenobamate has brought down the level of my seizures (I'm only having absence seizures now). Yet the side effects are annoying. I have been awake for 2 hours with a twitching/spasming foot. I get the whole dizzy, drowsy, and tiredness side effects, which I'm not happy with but am trying to live through it."

• Ian...
• Taken for 1 to 6 months
• August 30, 2024

Cenobamate for Seizures "I happen to be a historic case. Having undergone 2 neurosurgeries, then experimentally put on clobazam (1st in North America), where clobazam was a miracle med, I suddenly went 72 days clear! (Prior, I never went more than 2.) Then Topamax assisted me more, going 1024 days clear. I changed pharmacies, where it was VERY important to be on name brand, no generic meds, where the message was given but not listened to. I got generic clobazam and Topamax, leading to a flare of 203 grand mals the following week. Back on the name brand, the meds don’t work as well. I am being eased off of clobazam (down from 70 to at least 30 and determine what to do on my follow-up) and gradually merge onto the Xcopri, where since my dose has been 12.5 mg along with my Topamax and Vimpat, I have had no side effects. I presently am at 100 mg. My convulsions seemed to get under control once I was at 25 mg, but that cannot be conclusive. As my seizures come in clusters, it may have been a longer than usual period."

• mus...
• Taken for 6 months to 1 year
• December 16, 2024

Cenobamate for Seizures "I have a brain tumor and experience simple focal seizures in my left foot/leg. Prior to medication, I was experiencing a seizure every other day. When I started taking Xcopri, I was taking Keppra and Vimpat. The main symptom that I have experienced with Xcopri is debilitating dizziness for about an hour after taking my daily dose in the AM (50 mg). I eat a large meal to mitigate the effects, but the dizziness is so bad that I cannot safely stand, even with a cane. The effectiveness of controlling my seizures is worth it, but that is the side effect that is most clear to me. I have to schedule my day around this side effect."

• Som...
• Taken for 1 to 2 years
• July 1, 2024

Cenobamate for Seizures "Made my already bad memory worse, was extremely dizzy, and it started giving me horrible rage and anger issues. Talked with a doctor, lowered the dosage, took B6 to help with the other side effects. Got the dosage right and it worked wonders in stopping the seizure onset."

• JJK...
• Taken for 1 to 6 months
• November 6, 2021

For Seizures "Not a big fan of cenobamate, bad side effect profile, caused me to have horrendous nerve pain in my foot, was very sedating and impaired my memory, most effective drug at controlling simple focal epilepsy, although still only cut it down to 1 every 5 weeks, which isn't good enough to get me a driver's license. Ended up dropping after 4 months and switched to Keppra."

• Sim...
• Taken for 1 to 6 months
• February 19, 2025

Cenobamate "In my childhood, the seizures were just lightheadedness that lasted 5 to 10 seconds, but around my early to mid-20s, they got heavier. For at least 20 years, I must have tried at least 20 different AEDs and combinations of them, but they either only barely worked, didn't work, or made it worse until, a few years ago, I got a VNS implant, which started making a difference, and a few months ago, I was prescribed 3x100 mg Xcopri per day with some other AEDs, and I haven't had a seizure in about 6 months! The main side effect for me is drowsiness, so I take it at night with my other nighttime AEDs. When I started taking them, they were a bit difficult to swallow (narrow throat), but it got better over time. I just hope the Xcopri keeps working for me, unlike many other AEDs I've taken over the years that worked a few weeks or months, then stopped for some reason."

• Ano...
• Taken for 6 months to 1 year
• June 7, 2025

Cenobamate for Seizures "Used in combination with lamotrigine. Been seizure-free for 7 months. Side effect: lack of energy and sleepiness (sleep 9-10 hrs a night plus a 30-60 min nap). NOTE: I cannot recommend this drug - only a doctor can."

• Ano...
• Taken for 6 months to 1 year
• May 29, 2025

For Seizures "I have been on every seizure medication available for over 20 years. The medication is very good for controlling my seizures but making me very tired every day and most of all it has affected my sex life badly."

• Mik...
• Taken for 1 to 2 years
• August 18, 2024

For Seizures "This medication has drastically changed things. I’m more than a year seizure-free. I’ve had seizures for 36 years. Like many others, I take other medication, e.g., Keppra and others. I’ve reduced one of my medications and started slowly on cenobamate, where I now take 200 mg daily. Other factors might have contributed. I had lost quite a bit of weight, this was happening before I started to take cenobamate. I did find my diet changed. Foods that I liked, I would no longer eat, and I didn’t always want breakfast in the beginning of the change to cenobamate. Reducing my other meds, the seizures were intense, and I had more than one seizure at night. My seizures are all when I sleep. After a couple of months, when I was taking the regular dose, seizures stopped. Strange to say, I’ll put up with the strange eating habits and tiredness for no seizures."

• TST...
• Taken for 1 to 2 years
• June 8, 2024

For Seizures "Along with two other medications, Xcopri has really helped with my drug-resistant focal bi-temporal epilepsy. It's the only medication that has stopped the convulsive-type seizures, which were getting very dangerous for me. I had fallen into the bathtub as I was having a seizure early one morning. When I first started taking Xcopri, I was just so relieved and so happy as I was at the end of my rope. It's been a lifesaver for me."

• Lia...
• Taken for 6 months to 1 year
• October 6, 2024

For Seizures "I started taking cenobamate last August, starting slowly until maximum dosage 200 mg. I also have autism. I started initially with balance issues, though my seizures were getting under control. But later on, I started to get very aggressive and have nightmares and feel really tired. Things haven't improved much, though I have reduced the medication to 125 mg, but my life has changed for the worse."

• Nin...
• Taken for 6 months to 1 year
• April 20, 2024

For Seizures "This medication has made me feel like a new person. Unfortunately, I will stop taking this because of the price. I am on Medicare and was told today that I have reached my gap. No more coverage until I pay $8000 for prescriptions. How can I pay that much?"

• mdb...
• Taken for less than 1 month
• July 20, 2025

Cenobamate for Seizures "Let me start by saying: ask your doctor to be honest about side effects and then list the pros versus the cons. My experience has been terrible, side effects that include nausea, abdominal pain, constipation, headaches, double vision, and severe dizziness. Add the fact that certain migraine medicines (Qulipta, Nurtec) interact with Xcopri was the deal breaker, but I tried to push through the first 3 weeks and failed. I was unable to do so because the side effects weren't worth adjunctive therapy. New isn't always the best."

• Ano...
• Taken for 6 months to 1 year
• August 24, 2025

Cenobamate for Seizures "I have been taking Keppra for 6 years, 1000 mg twice a day, and Depakote 500 mg twice a day. Have had breakthrough seizures the entire time. My new neurologist (who specializes in epilepsy) weaned me off Depakote and added Xcopri 500 mg. Thankfully and blessed, I have been seizure-free for almost a year!"

• Anonymous
• Taken for 1 to 6 months
• June 17, 2023

Cenobamate for Seizures "Xcopri has given me many side effects, including fainting, fast heartbeat, weakness, and more. The side effects I've experienced are not worth it."

• Xco...
• Taken for 6 months to 1 year
• February 11, 2024

Cenobamate for Seizures "Has been excellent in terms of seizure control but needing to reduce dose due to side effects - not being able to wake up & aggression."

• Sco...
• Taken for less than 1 month
• August 15, 2024

Cenobamate for Seizures "Seizures are great, but lots of side effects: slurred speech, off balance when I walk, constipation, weight gain, and tiredness. And these are some that I can think of."

• Anonymous
• August 30, 2022

Cenobamate for Seizures "It works! It is 1,800 for a 30-day supply if you don't have the manufacturer coupon."

• Ter...
• Taken for 6 months to 1 year
• May 30, 2025

Cenobamate for Seizures "It makes me sleepy at 7 pm. I wake up at 3:30 am eating."

• Tri...
• Taken for 1 to 6 months
• August 21, 2024

For Seizures "Lack of sex drive, always feeling tired and lethargic."

• Har...
• Taken for 1 to 6 months
• April 14, 2024

Cenobamate for Seizures "Xcopri has been good during all increases up to 200mg. By day 5 at 200mg, we experienced dizziness, loss of balance, verbal confusion, headaches, heart palpitations, and overall fatigue and weakness."

• Edd...
• Taken for 1 to 6 months
• July 14, 2024

Cenobamate for Seizures "Xcopri has been my favorite medicine for seizures since it blocks sodium ion channels and does good to GABA. The medicine has reduced my seizures to one per month."

• Anonymous
• Taken for 1 to 2 years
• January 2, 2024

Cenobamate for Seizures "Works, have the fewest seizures I've ever had, maybe one small one at night."

• Cal...
• Taken for 1 to 2 years
• October 18, 2024

Cenobamate for Seizures "I still have seizures, but they aren't as bad, where I used to bite my tongue bad, I now stay more aware and can ride them out better."

• Kit...
• Taken for 6 months to 1 year
• March 3, 2024

Cenobamate for Seizures "Very effective for focal seizures for about 9 months. The auras are creeping back over the past few months, and I had several breakthrough seizures during a recent bout of flu."