Skip to main content

Does Xcopri cause weight gain or weight loss?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Oct 20, 2022.

Will Xcopri tablets (cenobamate) cause me to gain weight or lose weight?

Official answer

by Drugs.com

Yes, Xcopri can cause weight loss for a small percentage of users. In clinical trials up to 2% of patients experienced weight loss, and up to 5% of patients had decreased appetite. Most people will not see a change in weight.

Xcopri (cenobamate) is FDA approved medicine used for the treatment of partial-onset seizures in adult patients.

Medicines used to treat seizures (also called antiepileptic drugs or anticonvulsants) are usually taken long term so side effects of significant weight gain or weight loss overtime can cause marked health issues. Usually weight gain or weight loss only affects a small percentage of patients.

The antiepileptic drugs (AEDs) are sometimes divided into groups by how they may affect weight.

Antiepileptic drugs that may cause:

weight gain:

  • gabapentin
  • pregabalin
  • valproic acid
  • vigabatrin
  • possibly carbamazepine

weight neutral:

  • lamotrigine,
  • levetiracetam
  • phenytoin

slight weight loss:

  • felbamate

strong weight loss:

  • topiramate
  • zonisamide

If you are concerned about weight loss or weight gain may be due to your medication it is important to discuss this with your doctor.
Note: You should not to discontinue taking Xcopri or other antiepileptic drugs without consulting with your healthcare provider.

For more information on Xcopri click here: Xcopri Medication Information

References
  • Xcopri Prescribing Information: [Accessed October 20, 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/212839s006s007lbl.pdf
  • Weight issues for people with epilepsy--a review: [Accessed October 20, 2022] https://pubmed.ncbi.nlm.nih.gov/18047602/
  • Weight-reducing side effects of the antiepileptic agents topiramate and zonisamide: [Accessed October 20, 2022] https://pubmed.ncbi.nlm.nih.gov/22249827/#:~:text=Several%20antiepileptic%20drugs%20(AEDs)%20are,loss%20as%2C%20e.g.%2C%20felbamate.

 

Read next

Xcopri (generic name: cenobamate) is a schedule 5 controlled substance (CV) first approved in 2019. It is an oral tablet used for the treatment of partial-onset seizures in adult patients with epilepsy. Xcopri is classified as a controlled substance by the DEA because it may be habit-forming and lead to abuse or dependence. Continue reading

Obesity is a major risk factor for covid-19 and people who are obese are more likely than those who are not obese to contract Covid-19 at a younger age, develop severe Covid-19, require hospitalization, oxygen, mechanical ventilation, intubation, or admission into ICU, end up in hospital sooner, or die from Covid-19. Continue reading

The most common side effects with Ozempic include stomach problems, like nausea, vomiting, diarrhea, stomach pain and constipation. These tend to be mild-to-moderate and usually clear up in a few weeks in most people. Low blood sugar (hypoglycemia) is also a common side effect (when used with certain other diabetes treatments) and it can be serious. Continue reading

Related medical questions

Drug information

Related support groups

Medical Disclaimer