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Amphetamine and Irritability: What Users Say

Brand names: Adzenys XR-ODT, Dyanavel XR, Evekeo, Adzenys ER, Evekeo ODT

Irritability: mentioned by 9 users (6.4%)

Based on user experiences from 141 Amphetamine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

anxiety 10.6%
insomnia 10.6%
loss of appetite 7.1%
irritability 6.4%
depression 5.7%
mood swings 5.7%
headaches 5.0%
tiredness 5.0%
brain fog 4.3%
dry mouth 4.3%

Reviews for Amphetamine

Commonly mentioned side effects
  • Cat...
  • Taken for 1 to 2 years
  • August 9, 2018

Amphetamine for ADHD "This medication is a million times better than Adderall for my ADHD symptoms-lack of motivation, emotional dysregulation, sensory overload, procrastination, and feeling overwhelmed by even the simplest, most everyday tasks. Adderall also caused side effects such as upper gastrointestinal issues, irritability, and the dreaded crash. Adzenys does not, for the most part. I also like how the drug is brand-name, I know what I'm getting each month rather than the 'generic roulette' of Adderall, where every generic was different (yet none was as effective as Adzenys). Finally, I think the orally disintegrating tablet (tastes good, by the way) makes the drug more consistent than if it were swallowed and wholly processed via the GI system. No one seems to know about this medication, it's too bad because it is a gem for my ADHD symptoms. I hope it isn't discontinued for this reason."

10 / 10
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66 Report
  • Sen...
  • Taken for 2 to 5 years
  • April 2, 2018

Amphetamine for ADHD "After Adderall and Ritalin made me incredibly irritable, moody, and anxious, I tried Evekeo, and it is my miracle drug! I've been on it for 2 years now and have no complaints. I recommend this drug if you have failed the more popular stimulants! 11/10 recommend!!"

10 / 10
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40 Report
  • all...
  • July 30, 2016

Amphetamine for ADHD "20 y/o college female. Keeps me alert, focused, awake. I usually wait a little bit after taking it to have caffeine, not necessary, just personal preference based on how it makes me feel. Switched to it after taking Vyvanse for almost a year, which was great, but it eventually made me irritable. So far, I have loved this medication. No side effects, but if you take a dose too late in the day, it will keep you up at night. I take 5 mg in the morning and then another dose when I really need to focus. Shorter release, so I feel like I need a nap after 4-5 hours. Overall, would recommend."

8 / 10
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23 Report

Frequently asked questions

  • Din...
  • Taken for less than 1 month
  • June 6, 2019

Amphetamine for ADHD "Having a high metabolism, my medications wear off very quickly. Dr. and I talked about trying Evekeo, but decided to try adding one more dose of Adderall XR to the mix. When that didn’t help, I tried Evekeo and discontinued the Adderall XR but kept the afternoon doses of IR. As for Evekeo, I had a very bad reaction to it. My face broke out, and not pimples but sores that are now going to scar. My depression (which I haven’t had in a while due to the consistency of taking medication) was three times worse, I went to a very dark place. I went days without sleeping, no motivation or drive to do anything, very irritable, very mean, not social at all, terrible intrusive thinking, pushed away anyone that was close to me, no appetite at all, headaches, muscle soreness, and vomiting/diarrhea. Thankfully, we stopped the medication, but I don’t want to feel like this ever again!"

1 / 10
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13 Report
  • Gin...
  • September 28, 2016

Amphetamine for ADHD "I enjoyed Evekeo. It was great when it came to improving focus. I also have shift work disorder, so for me, stimulants are great as they help me overcome the hump I hit every morning when I just want to go to bed and sleep all day. My wife complained that I was getting really hard to live with compared to normal. I knew I was more irritable than normal. Over the 5 months I took it, I did feel like the level of irritability and argumentativeness was steadily increasing. I stopped taking it when my wife told me I was starting to become unbearable. I usually get 2 migraines a year, but while on Evekeo, I had 3 in 5 months."

8 / 10
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17 Report

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  • Joh...
  • Taken for 1 to 6 months
  • March 13, 2022

Amphetamine for ADHD "Excellent medicine for those who just want to have focus without the euphoria or racing thoughts that often make us anxious. I've been taking Adderall IR generic from (Teva) for over 5 years. I changed a few times to Adderall XR brand when I couldn't find Teva's on the market anymore. I came to the generic by (Lanette), which works, but it makes me much more agitated and anxious than focused with tasks. Evekeo won't give you that euphoria that Adderall gives, but it will give you the results you need from your treatment because I just changed it, and I soon realized that I was finally able to do things without overthinking and not knowing where to start. Evekeo is purer than Adderall because it is amphetamine sulfate only, with the composition (levoamphetamine) 50/50 (dextroamphetamine). Adderall is a mixture of salts containing 4 types of salts, and the composition is (levoamphetamine) 25/75 (dextroamphetamine). I take 10mg 4x a day = 40mg. If 20mg pills were made, it would be great."

10 / 10
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6 Report
  • Con...
  • April 29, 2018

Amphetamine for ADHD "We switched from Vyvanse in the morning and Focalin in the afternoon because the cost was getting way too expensive for both, and insurance wasn't allowing us to get name brand so we could use a copay card. After switching to Evekeo, my 11-year-old son started having major anger and frustration problems in school. His teachers said it worked well the first couple of days for his focusing, but then it was like he wasn't on it at all. He started becoming extremely defiant in school, hitting himself in the face because he was mad and frustrated. Calming him down was next to impossible. We were getting calls on a daily basis. Not sure how we will do it, but we are more than likely going back to his previous medication."

1 / 10
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11 Report

More FAQ

  • ano...
  • Taken for 6 months to 1 year
  • March 20, 2025

Amphetamine for ADHD "I actually quite like Evekeo, it makes me feel like a normal person with normal motivation levels, lol. I will say around other people I can get agitated easily, but that's kind of about it. Obviously, I feel like my energy levels are lower on this drug, but it's really just because my brain isn't moving at 100 miles an hour, and I actually like how that feels. I've tried Vyvanse, Adderall, and Focalin, to name a few, but I really do like Evekeo so far. I like that it's short-acting, but if you are looking for something that has a longer duration time, then maybe this isn't for you. Another side effect of Evekeo is that sometimes, towards the beginning of taking it, I would have insomnia spells, but I experienced this side effect with every other ADHD drug I took, so I just dealt with it. After a couple of weeks, though, it went away. I also only take Evekeo as needed, which could mean taking it for a week straight every day or just once a week, and it doesn't mess with my system, which is a plus."

8 / 10
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  • Anonymous
  • October 27, 2011

For ADHD "My 5-year-old just started this medication, and no change in her became evident as it's supposed to after about 30 minutes. It actually made her Tourette's worse and made her itch and irritable. Hope you have better luck!"

3 / 10
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9 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.