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Amphetamine and Insomnia: What Users Say

Brand names: Adzenys XR-ODT, Dyanavel XR, Evekeo, Adzenys ER, Evekeo ODT

Insomnia: mentioned by 15 users (10.6%)

Based on user experiences from 141 Amphetamine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

anxiety 10.6%
insomnia 10.6%
loss of appetite 7.1%
irritability 6.4%
depression 5.7%
mood swings 5.7%
headaches 5.0%
tiredness 5.0%
brain fog 4.3%
dry mouth 4.3%

Reviews for Amphetamine

Commonly mentioned side effects
  • Hon...
  • January 9, 2020

For ADHD "As an adult with ADHD, I love this medication because it allows me to adjust the dosage as needed. I don't take my medication on weekends and on holidays. So when I get back on my meds for work, I can start out with a lower dosage rather than shocking my system with my regular high dosage. It's the best medication overall in terms of allowing me to concentrate and not making me into a zombie, allowing me to eat even with a decreased appetite, and not making me an insomniac. However, this medication is WAY too expensive. The new manufacturer's coupon is pitiful, covering only up to a max of $140 when the medication itself is over $400. Previously, I was only paying $20 per month for my prescription the coupon. Of course, my insurance company wants me to use other (cheaper) drugs that I've tried, but don't work for me in terms of helping me concentrate and/or the side effects are too strong. Insurance companies need to stop trying to play doctor and give patients the medications that they need."

8 / 10
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39 Report
  • Ari...
  • Taken for less than 1 month
  • March 18, 2018

For ADHD "I was on 30 mg Adderall XR for about a year, which worked well for me except for the crash. It became much less effective at that dose after being on it almost a year, but my doctor has a cap on the Adderall dosage she will prescribe. Just switched to Adzenys 12.5 mg at my last appointment. I've been taking it for almost a week. I'm completely unfocused and back to having trouble getting to sleep. Not that it does nothing at all...mostly I just feel like I'm in another world. My thoughts are definitely slowed down, but more distracting from reality. I'm definitely feeling really chill overall. It does last longer than Adderall, if you want to feel like you're in another worldly state for 12 hours or more. Things affect people differently, and I'm sure this is very helpful to a lot of people, but I tried to Google similar experiences and found none, so I wanted to write a review in case anyone else might be experiencing the same."

2 / 10
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44 Report
  • Jay...
  • August 29, 2018

For ADHD "I've been on Adzenys for a little over a year now and have mixed feelings about the drug. I'm a 23-year-old male, not taking any other medications, and in good physical condition. Currently prescribed the 15.7 mg dose, but am going to make the switch to Adderall XR for a few reasons. First, this drug can be extremely hard to locate, and if a pharmacy doesn't have it, it tends to take a while to get it in. Secondly, it has caused severe insomnia. I see some other people have had that subside within a few weeks, but I've had it for practically the entire time. Lastly, its ability to help me maintain drive and focus is too infrequent. Sometimes it's a miracle of a drug, other times, I misplace and lose things one after the other and can't remember things I had just heard or read. It's like sometimes I am completely there and focused, and other times I'm floating around, if that makes any sense."

6 / 10
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41 Report

Frequently asked questions

  • Ris...
  • Taken for 1 to 6 months
  • September 28, 2018

For ADHD "This has been a great medicine for my son. He has tried six different meds but never stayed with them because either they didn’t last all day, stopped eating, had trouble sleeping, experienced mood swings, crashed hard when the meds wore off, were ineffective, or turned him into a zombie. He is five but almost six years old, and he is taking 3.5 mL at around 7 AM daily. It wears off around 6:30 PM, and there is no hard come down. Before this med, we had to give my son melatonin every night for him to be able to fall asleep before midnight. We don't have to anymore. This is also the only med where he has an appetite. I was having to force-feed him his meals because he would never want to eat on other meds. Now he is eating great and healthy. It’s also so great to see my son’s personality and humor shine on this medicine because it works well enough to slow his brain down from the 100 mph it usually goes, so he can focus on saying proper sentences and conveying his thoughts, but without turning him into a zombie."

10 / 10
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24 Report
  • lde...
  • Taken for less than 1 month
  • April 23, 2023

For ADHD "Recently, I switched from taking Adderall to Vyvanse and then to Adzenys. I have been taking short-acting Adderall tablets on and off for the past twenty years, twice a day. I tried Vyvanse hoping that it would last longer during the day, up to twelve hours. Unfortunately, I experienced terrible side effects, such as mood swings, insomnia, and zero focus. I tried doses ranging from 40-70mg and spent six months on it, only to switch to Adzenys. I started taking Adzenys last month, and it is more like Adderall. It provides a mellow focus and does not cause additional anxiety. However, it only lasts for about six to eight hours, and my doctor is hesitant to prescribe it twice a day. We are increasing the dose this month, and I hope it is more effective. The packaging is inconvenient, but the medication works, and the carry case is nice and fits in my locked bag for safety. The easy-to-take tabs are definitely a hazard around children because they look like candy or something. However, if you are responsible for your medications and keep them locked up for safety, it should not be a problem. The pharmacy takes a long time to restock it as well."

9 / 10
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7 Report

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  • bip...
  • Taken for 1 to 6 months
  • May 19, 2018

For ADHD "Adzenys XR-ODT gave me great, smooth, long-lasting effects. I’ve had a bit of an increase in physical anxiety/agitation, but that’s largely subsided. Also had some difficulty falling asleep, but I stopped having this effect within 2 weeks. I’m honestly amazed that I have absolutely zero crash with Adzenys, even as I’ve increased my dose a bit. I’ve always experienced crashes with ADD drugs until I found Adzenys."

9 / 10
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15 Report
  • Kat...
  • August 2, 2016

For ADHD "Adzenys is the first stimulant medicine I've ever tried. I went through a very bad depression from a car accident, and working out, eating right, and trying every antidepressant just made me even more depressed. Since taking Adzenys, I'm back to my old happy, energetic self! I don't have ADD or ADHD, so I can't comment on that, but I do know this has helped me get over most of my depression and helped me to get back to working out and just got me off the couch and out of my rut. The energy was so immense the first week, and then I started to get used to it, which I've quite enjoyed. I'm not running around like a madwoman, but I have the energy and the drive to be my normal self again. At first, I had insomnia for a week, but Benadryl helped for sure!"

9 / 10
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21 Report

More FAQ

  • ADH...
  • Taken for 1 to 6 months
  • January 24, 2017

For ADHD "My daughter was diagnosed with ADHD a few years ago (she's 13 now) and was on Adderall XR 25 mg for a few years. She was never hungry and had a hard time sleeping. We switched her to Adzenys XR 12.5 (lower than her Adderall dose equivalent). It doesn't seem to last as long -- but then again, it's not as strong. The good thing is her appetite is back, and she doesn't have trouble sleeping. She also doesn't complain about not feeling like herself (she is usually a pretty happy kid but complained the Adderall made her withdrawn). She's doing fairly good in school, though she has some learning challenges in some areas. Although she's only been on it a few months, I am relatively happy with the results."

8 / 10
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14 Report
  • ADH...
  • Taken for 1 to 6 months
  • January 24, 2017

For ADHD "My daughter was diagnosed with ADHD a few years ago (she's 13 now) and was on Adderall XR 25 mg for a few years. She was never hungry and had a hard time sleeping. We switched her to Adzenys XR 12.5 (lower than her Adderall dose equivalent). It doesn't seem to last as long -- but then again, it's not as strong. The good thing is her appetite is back, and she doesn't have trouble sleeping. She also doesn't complain about not feeling like herself (she is usually a pretty happy kid but complained the Adderall made her withdrawn). She's doing fairly good in school, though she has some learning challenges in some areas. Although she's only been on it a few months, I am relatively happy with the results."

8 / 10
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14 Report
  • Cha...
  • July 23, 2016

For ADHD "I'm on day 2 of Adzenys. I like that I take it once. But the texture is gritty once dissolved. It's a dissolvable pill, so what do you expect? I do experience dry mouth and a slight decrease in appetite, but it's nothing serious. My doctor started me on a pediatric dose of 6.3 milligrams once a day. Another problem I see is that I'm having a hard time falling asleep. It could be because I take the medication around 11 o'clock in the morning, but that's the time I get up. So it's honestly too early for me to tell. We will see once I get a routine going and school starts again."

8 / 10
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17 Report
  • Mel...
  • Taken for less than 1 month
  • October 3, 2018

For ADHD "My doctor suggested switching me from 70 mg of Vyvanse to 10 mg of Evekeo (2x per day) to see if that eliminated the insomnia issue I was having with Vyvanse. After a week on Evekeo, I'd go back to Vyvanse in a heartbeat. I've been taking stimulant medication for ADD for almost 30 years, and I have never had one be utterly ineffective at helping me focus. With Evekeo, it's like I took nothing at all. Zero ability to focus. To make matters worse, I'm experiencing 6 of the main side effects, one of which is a raging headache that sticks around all day (and feels like a migraine when the med first kicks in). It makes me feel very wired and shaky, too. I just called my doctor and asked to be squeezed in ASAP so I can switch to something else (might go back to Adderall), as I cannot keep taking Evekeo for another 20+ days."

2 / 10
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10 Report
  • lon...
  • Taken for less than 1 month
  • April 27, 2023

For ADHD "I was put on this drug, and today was my first day. I appreciate these reviews and probably should wait before I review. I've been on Adderall XR 20 and one Adderall quick release 20 daily for the past two years. Before this, the dose was higher, but then I turned 50, so... I'm not anxious, and don't have the butterflies in my stomach. I am good so far and really hope those reports about messing up sleep don't happen to me."

6 / 10
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3 Report
  • Fai...
  • October 24, 2017

For ADHD "I've been on ADHD medication for a very long time. My body had built a pretty strong tolerance to stimulants. I combine normally IR Adderall, Vyvanse, and XR Adderall, and now I combine Zenzedi (great, btw), IR Adderall, and this medication, and the only thing I noticed is no increase in focus at all, but some weird increase in insomnia, which is unusual because it's not like an anxiety insomnia, but a strange almost increased ADHD insomnia I had growing up. Normally, after taking my ADHD medications, I can sleep without issue, but this one causes me to just stay awake without jitters, focus, anxiety, or anything. I don't care for it."

6 / 10
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6 Report
  • Bet...
  • Taken for less than 1 month
  • May 5, 2022

For ADHD "I was 28 when diagnosed with ADHD, and I was started on 20 mg Adderall 2x daily. It worked okay, but it was lacking. I then, at my next follow-up, was prescribed 30 mg XR Adderall. She told me if I started to crash, take one of my 20 mg IR. The 30 mg XR once a day, and it worked way better! Well, due to a neck injury that happened when I was 19, and 3 levels of artificial discs. She told me that my prescription 'credit score' was on the high side. Of course, I was open to try the Adzenys. Okay, the pharmacy was 45 minutes away, and of course, they only had the exact amount I needed. So, I start this new medication in hopes of becoming refocused, less irritated. You know, all the things that come about when you’re unmedicated. I’ve been on this medication for at least a week. However, I don’t take it on the weekend. Since Monday, I’ve noticed I don’t feel as if it works during the day, but I have experienced the worst insomnia."

4 / 10
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  • Gan...
  • Taken for less than 1 month
  • August 9, 2019

For ADHD "CAUTION!!! THIS DRUG IS DANGEROUS!!! The cons outweigh the pros. I took this drug to treat my ADHD. It did make me focus more, and that's the only positive thing I could say. Other than the physical side effects like gum bleeding, hair falling out, cold sweats, and insomnia. The emotional side effects included loss of personality, made me feel more psychotic. STAY AWAY FROM ADZENYS."

1 / 10
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8 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.