Lansoprazole, Amoxicillin, and Clarithromycin
Generic Name: Lansoprazole, Amoxicillin, and Clarithromycin (lan SOE pra zole, a moks i SIL in, & kla RITH roe mye sin)
Brand Name: Prevpac
Uses of Lansoprazole, Amoxicillin, and Clarithromycin:
- It is used to treat or prevent GI (gastrointestinal) ulcers caused by infection.
What do I need to tell my doctor BEFORE I take Lansoprazole, Amoxicillin, and Clarithromycin?
- If you have an allergy to lansoprazole, amoxicillin, clarithromycin, any penicillin, or any other part of lansoprazole, amoxicillin, and clarithromycin.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If this medicine caused liver problems before.
- If you have ever had a long QT on ECG or other heartbeat that is not normal.
- If you have any of these health problems: Low potassium or magnesium levels.
- If you have kidney or liver disease and are taking colchicine.
- If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with lansoprazole, amoxicillin, and clarithromycin, like certain drugs that are used for high cholesterol, migraines, or mood problems. There are many drugs that must not be taken with this medicine.
- If you are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
- If you are breast-feeding or plan to breast-feed.
This is not a list of all drugs or health problems that interact with lansoprazole, amoxicillin, and clarithromycin.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Lansoprazole, Amoxicillin, and Clarithromycin?
- Very bad and sometimes deadly allergic reactions have rarely happened. Talk with your doctor.
- Call your doctor if you have throat pain, chest pain, very bad belly pain, trouble swallowing, or signs of a bleeding ulcer like black, tarry, or bloody stools, throwing up blood, or throw up that looks like coffee grounds. These may be signs of a worse health problem.
- Avoid drinking alcohol while taking lansoprazole, amoxicillin, and clarithromycin.
- This medicine may raise the chance of hip, spine, and wrist fractures in people with weak bones (osteoporosis). The chance may be higher if you take this medicine in high doses or for longer than a year, or if you are older than 50 years old. Talk with your doctor.
- Low magnesium levels have rarely happened in people taking drugs like this one for at least 3 months. Most of the time, this has happened after 1 year of care. You will need to have your blood work checked if you will be taking lansoprazole, amoxicillin, and clarithromycin for a long time or if you take certain other drugs like digoxin or water pills. Talk with your doctor.
- Very bad and sometimes deadly liver problems have happened with this medicine. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- A very bad and sometimes deadly type of heartbeat that is not normal (long QT on ECG) has happened with lansoprazole, amoxicillin, and clarithromycin. Some other drugs taken along with this medicine may add to this effect. Get medical help right away if your heartbeat does not feel normal.
- Lupus has happened with lansoprazole, amoxicillin, and clarithromycin, as well as lupus that has gotten worse in people who already have it. Tell your doctor if you have lupus. Call your doctor right away if you have signs of lupus like a rash on the cheeks or other body parts, sunburn easy, muscle or joint pain, chest pain or shortness of breath, or swelling in the arms or legs.
- A very bad and sometimes deadly reaction has happened with this medicine. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. Talk with the doctor.
- If you have heart disease, talk with your doctor. In one study, people with heart disease who took clarithromycin had a higher chance of death a year or more later than those who did not take clarithromycin. The cause of this was not known. Other studies have shown different results.
- If you are 65 or older, use lansoprazole, amoxicillin, and clarithromycin with care. You could have more side effects.
- Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking this medicine.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using lansoprazole, amoxicillin, and clarithromycin while you are pregnant.
How is this medicine (Lansoprazole, Amoxicillin, and Clarithromycin) best taken?
Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- To gain the most benefit, do not miss doses.
- Keep using lansoprazole, amoxicillin, and clarithromycin as you have been told by your doctor or other health care provider, even if you feel well.
- Take this medicine before a meal.
- Do not take sucralfate within 30 minutes of lansoprazole, amoxicillin, and clarithromycin.
- Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
- If you have high blood sugar (diabetes), do not use Clinitest®. Use some other urine glucose testing like Clinistix® or Tes-Tape®.
- Take calcium and vitamin D as you were told by your doctor.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take lansoprazole, amoxicillin, and clarithromycin.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine may affect how much of some other drugs are in your body. If you are taking other drugs, talk with your doctor. You may need to have your blood work checked more closely while taking this medicine with your other drugs.
- Use care if you have risks for soft, brittle bones (osteoporosis). Some of these risks include drinking alcohol, smoking, taking steroids, taking drugs to treat seizures, or having family members with osteoporosis. Talk with your doctor about your risks of osteoporosis.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of low magnesium levels like mood changes, muscle pain or weakness, muscle cramps or spasms, seizures, shakiness, not hungry, very bad upset stomach or throwing up, or a heartbeat that does not feel normal.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Dizziness or passing out.
- Fast or slow heartbeat.
- Swelling in the arms or legs.
- Bone pain.
- Low mood (depression).
- Fever or chills.
- Sore throat.
- Shortness of breath.
- A big weight loss.
- Feeling very tired or weak.
- For females, vaginal yeast infection. Report itching or discharge.
- Tooth staining.
- Redness or white patches in mouth or throat.
- It is common to have diarrhea when taking lansoprazole, amoxicillin, and clarithromycin. Rarely, a very bad form of diarrhea called Clostridium difficile (C diff)–associated diarrhea (CDAD) may occur. Sometimes, this has led to a deadly bowel problem (colitis). CDAD may happen while you are taking this medicine or within a few months after you stop taking it. Call your doctor right away if you have stomach pain or cramps, very loose or watery stools, or bloody stools. Do not try to treat loose stools without first checking with your doctor.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
What are some other side effects of Lansoprazole, Amoxicillin, and Clarithromycin?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Bad taste in your mouth.
- Loose stools (diarrhea).
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Lansoprazole, Amoxicillin, and Clarithromycin?
- Store at room temperature.
- Protect from light.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Check with your pharmacist about how to throw out unused drugs.
Consumer Information Use and Disclaimer
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about lansoprazole, amoxicillin, and clarithromycin, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about lansoprazole, amoxicillin, and clarithromycin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using lansoprazole, amoxicillin, and clarithromycin.
Review Date: December 6, 2017
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