Varubi Side Effects

Generic name: rolapitant

Medically reviewed by Drugs.com. Last updated on Sep 27, 2024.

Note: This document provides detailed information about Varubi.

Applies to rolapitant: oral tablet Side Effects associated with rolapitant. Some dosage forms listed on this page may not apply specifically to the brand name Varubi.

Applies to rolapitant: oral tablet.

Precautions

Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.

Do not take this medicine if you are also using pimozide (Orap®) or thioridazine (Mellaril®). Using these medicines together may cause serious unwanted effects, including heart rhythm problems.

Talk with your doctor before using this medicine if you plan to have children. Some women who use this medicine have become infertile (unable to have children).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Varubi

Along with its needed effects, rolapitant (the active ingredient contained in Varubi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rolapitant:

Other side effects of Varubi

Some side effects of rolapitant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to rolapitant: intravenous emulsion, oral tablet.

General adverse events

The most commonly reported side effects included decreased appetite, neutropenia, dizziness, and hiccups.^[Ref]

Gastrointestinal

• Common (1% to 10%): Abdominal pain, constipation, dyspepsia, stomatitis
• Uncommon (0.1% to 1%): Abdominal distention, diarrhea, nausea, oral fungal infection
• Rare (less than 0.1%): Abdominal discomfort, bowel habit change, dry mouth, gastroesophageal reflux disease, oral candidiasis, retching^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache
• Uncommon (0.1% to 1%): Disturbance in attention, dysgeusia, somnolence
• Rare (less than 0.1%): Balance disorder, movement disorder, syncope^[Ref]

Hematologic

• Common (1% to 10%): Anemia, neutropenia
• Rare (less than 0.1%): Decreased neutrophil count, increased international normalized ratio (INR), leukopenia, thrombocytopenia^[Ref]

Metabolic

• Common (1% to 10%): Decreased appetite
• Rare (less than 0.1%): Dehydration, hypomagnesemia^[Ref]

Respiratory

• Common (1% to 10%): Hiccups^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Myalgia
• Rare (less than 0.1%): Arthralgia, back pain, muscular weakness, rhabdomyolysis^[Ref]

Other

• Uncommon (0.1% to 1%): Asthenia
• Rare (less than 0.1%): Gait disturbance, hypoacusis, tinnitus^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Insomnia
• Rare (less than 0.1%): Anxiety, bruxism^[Ref]

Dermatologic

• Rare (less than 0.1%): Acneiform dermatitis, alopecia, dry skin^[Ref]

Hypersensitivity

• Rare (less than 0.1%): Angioedema, hypersensitivity^[Ref]

Cardiovascular

• Rare (less than 0.1%): Hypertension, increased heart rate^[Ref]

Immunologic

• Rare (less than 0.1%): Candidiasis^[Ref]

Ocular

• Rare (less than 0.1%): Blurred vision^[Ref]

See also:

Frequently asked questions

• Will a single dose of Varubi stop vomiting for days?
• How long does a dose of Varubi last?

Further information

Varubi side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer