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NK1 receptor antagonists

What are NK1 receptor antagonists?

Neurokinin-1 (NK1) receptor antagonists are used for prevention of acute and delayed nausea and vomiting. The NK1 receptor antagonist competitively binds to the NK1 receptor, which blocks the binding of substance P and prevents the emetic signal being transmitted. NK1 receptor antagonists can be used in conjunction with 5-HT3-receptor antagonists and corticosteroids to augment their antiemetic activity.

List of NK1 receptor antagonists:

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Drug Name Reviews Avg. Ratings
Varubi (Pro)
Generic name: rolapitant 		1 review
   
10
Emend (Pro)
Generic name: aprepitant 		15 reviews
   
8.5
Cinvanti (Pro)
Generic name: aprepitant 		0 reviewsAdd rating
Emend for Injection (Pro)
Generic name: fosaprepitant 		0 reviewsAdd rating

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Medical conditions associated with NK1 receptor antagonists:

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