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How long does a dose of Varubi last?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on March 15, 2023.

Official answer


Once you take one dose of Varubi, it has a long duration of action in your body for up to 5 days. Do not take Varubi more than once every 14 days.

Varubi (generic name: rolapitant) is a substance P/neurokinin 1 (NK1) receptor antagonist used in combination with other medicines to help prevent delayed nausea and vomiting associated with cancer treatment.

Nausea and vomiting that occurs from 1 to 5 days after the start of chemotherapy is referred to as delayed nausea and vomiting, and it can result in serious health complications.

What is the dose of Varubi?

  • Normally, on Day 1 of chemotherapy, you would take 2 Varubi tablets (180 mg) by mouth within 2 hours before you receive your anti-cancer medicine (chemotherapy).
  • You can take Varubi tablets with or without food.
  • Take this medicine exactly as your doctor tells you to take it.

This is not all the information you need to know about Varubi (rolapitant) for safe and effective use and does not take the place of talking to your doctor about your treatment. Review the full product information here, and discuss this information and any questions you have with your doctor or other health care provider.


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